Advances in genomics are expected to play a central role in medicine and public health in the future by providing a genetic basis for disease prediction and prevention. The transplantation of human gene discoveries into meaningful actions to improve health and prevent disease depends on scientific information from multiple disciplines, including epidemiology. This book describes the important role that epidemiologic methods play in the continuum from gene discovery to the development and application of genetic tests. It proceeds systematically from the fundamentals of genome technology and gene discovery, to epidemiologic approaches to gene characterization in the population, to the evaluation of genetic tests and their use in health services. These methodologic approaches are then illustrated with several disease-specific case studies. The book provides a scientific foundation that will help researchers, policy makers, and practitioners integrate genomics into medical and public health practice.
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Editorial Reviews
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"Human Genome Epidemiology is a valuable resource. ...the book proposes a useful framework for the derivation, interpretation, and dissemination of genomic information for the purpose of improving health." --JAMA
About the Author
Muin J. Khoury is at Centers for Disease Control and Prevention. Julian Little is at University of Aberdeen, Medical School, UK.
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Inside This Book
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Key Phrases - Statistically Improbable Phrases (SIPs):
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prior prob, flap endonuclease, genetic effect modifiers, chemokine receptor gene polymorphisms, human biologic materials, typed locus, connexin connection, beryllium sensitized, beryllium sensitization, pharmacokinetic strategies, genotype prevalence, effective genetic testing, research involving genetics, analytic validity, railroad track workers, analytic specificity, human genome epidemiology, appraising studies, hereditary neuropathy with liability, beryllium workers, nonsyndromic hearing loss, beryllium industry, beryllium disease, pharmacogenomic tests, dichotomous factors Key Phrases - Capitalized Phrases (CAPs): (learn more)
Hum Genet, United States, Med Genet, Nat Genet, Cancer Epidemiol Biomarkers Prev, New York, United Kingdom, Natl Cancer Inst, Genet Epidemiol, Cancer Res, Genet Med, Hum Mol Genet, Epidemiol Rev, Department of Health, Ann Intern Med, Oxford University Press, Ann Neurol, Ashkenazi Jewish, African Americans, Human Genome Project, Clin Genet, Occup Med, Clin Epidemiol, Ind Med, Task Force Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Surprise Me!
prior prob, flap endonuclease, genetic effect modifiers, chemokine receptor gene polymorphisms, human biologic materials, typed locus, connexin connection, beryllium sensitized, beryllium sensitization, pharmacokinetic strategies, genotype prevalence, effective genetic testing, research involving genetics, analytic validity, railroad track workers, analytic specificity, human genome epidemiology, appraising studies, hereditary neuropathy with liability, beryllium workers, nonsyndromic hearing loss, beryllium industry, beryllium disease, pharmacogenomic tests, dichotomous factors Key Phrases - Capitalized Phrases (CAPs): (learn more)
Hum Genet, United States, Med Genet, Nat Genet, Cancer Epidemiol Biomarkers Prev, New York, United Kingdom, Natl Cancer Inst, Genet Epidemiol, Cancer Res, Genet Med, Hum Mol Genet, Epidemiol Rev, Department of Health, Ann Intern Med, Oxford University Press, Ann Neurol, Ashkenazi Jewish, African Americans, Human Genome Project, Clin Genet, Occup Med, Clin Epidemiol, Ind Med, Task Force Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Surprise Me!
Citations (learn more)
2
books
cite this book:
- Gene-Environment Interactions: Fundamentals of Ecogenetics by Lucio G. Costa in Back Matter (1), Back Matter (2), and Back Matter (3)
- Nutritional Genomics: Impact on Health and Disease by Regina Brigelius-Flohé on page 372, and page 374
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