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Human Growth Hormone Pharmacology: Basic and CLinical Aspects (Pharmacology and Toxicology) [Hardcover]

Kathleen T. Shiverick (Editor), Arlan Rosenbloom (Editor)

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Book Description

ISBN-10: 0849383846 | ISBN-13: 978-0849383847 | Publication Date: May 9, 1995 | Edition: 1

This book addresses a wide range of basic and clinical issues in the physiology and pharmacology of growth hormone. The volume is organized like a textbook. It begins with factors contributing to GH gene expression, the functional relationships of the GH receptor, molecular biological analysis of the GH-GH receptor complex and proceeds to describe the insulin-like growth factor axis. Transgenic models are discussed for analysis of discrete effects. These discussions provide a bridge to clinically oriented discussions of growth abnormalities in GH deficient children, GH insensitivity due to deficiency of the GH receptor, and the concept of aging as a GH/IGF-I deficiency state. Discussions also include the immune system as a source and a responder to GH, GHRH, IGF-I and the effects of GH excess.

#outer_postBodyPS { display: none; } #psGradient { display: none; } #psPlaceHolder { display: none; } #psExpand { display: none; } This book addresses a wide range of basic and clinical issues in the physiology and pharmacology of growth hormone. The volume is organized like a textbook. It begins with factors contributing to GH gene expression, the functional relationships of the GH receptor, molecular biological analysis of the GH-GH receptor complex and proceeds to describe the insulin-like growth factor axis. Transgenic models are discussed for analysis of discrete effects. These discussions provide a bridge to clinically oriented discussions of growth abnormalities in GH deficient children, GH insensitivity due to deficiency of the GH receptor, and the concept of aging as a GH/IGF-I deficiency state. Discussions also include the immune system as a source and a responder to GH, GHRH, IGF-I and the effects of GH excess.

Product Details

Hardcover: 192 pages
Publisher: CRC-Press; 1 edition (May 9, 1995)
Language: English
ISBN-10: 0849383846
ISBN-13: 978-0849383847
Product Dimensions: 9.5 x 6.4 x 0.7 inches
Shipping Weight: 1.2 pounds
Amazon Best Sellers Rank: #3,721,434 in Books (See Top 100 in Books)

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Inside This Book (learn more)

First Sentence:
The growth hormone (GH) gene cluster contains five highly similar genes spanning 48 kb on chromosome 17. Read the first page

Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
growth hormone insensitivity syndrome, growth hormone receptor deficiency, physiologic mode, growth hormone transgenic mice, human growth hormone receptor, healthy old men, growth hormone binding protein, hybrid receptor, adipose mass, mutational data, binding determinants, dwarf mice, somatotropic axis, growth hormone treatment, growth factor binding proteins, recombinant human growth hormone, hypersensitive sites, prolactin receptor, replacement doses, untrained controls, placental villi, growth hormone deficiency, receptor dimerization, hypophysectomized rats

Key Phrases - Capitalized Phrases (CAPs): (learn more)
Acta Endocrinol, Endocrinol Metab, New York, Acta Paediatr, Endocrine Society, Growth Reg, Oriental Jewish, Bone Min, Cancer Res, Plenum Press

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Citations (learn more)

This book cites 33 books:

Lessons from Laron Syndrome (Pediatr) (v. 24) by Zvi Laron on page 104, and page 166
Therapeutic Modulation of Cytokines (Pharmacology and Toxicology) by M. W. Bodmer in Front Matter
Placental Toxicology (CRC Pharmacology & Toxicology: Basic & Clinical Aspects) by B. V. Rama Sastry in Front Matter
Pharmacology of the Skin (Handbooks in Pharmacology and Toxicology) by Hasan Mukhtar in Front Matter
Handbook of Mammalian Models in Biomedical Research (Pharmacology & Toxicology) by David B. Jack in Front Matter

See all 33 books this book cites

35 books cite this book:

Drug Delivery Systems, Second Edition (Pharmacology and Toxicology: Basic and Clinical Aspects) by Vasant V. Ranade in Front Matter
Immune Interferon: Properties and Clinical Applications (Pharmacology and Toxicology: Basic and Clinical Aspects) by Roumen G. Tsanev in Front Matter
Airway Wall Remodelling in Asthma (Pharmacology and Toxicology) by A. G. Stewart in Front Matter
Pharmacology in Exercise and Sports (Pharmacology and Toxicology) by Satu M. Somani in Front Matter
Angiotensin II Receptors (Handbooks in Pharmacology and Toxicology) by Robert R. Ruffolo Jr. in Front Matter

See all 35 books citing this book

Books on Related Topics (learn more)

Pediatric Endocrinology, Fifth Edition by Fima Lifshitz

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Pediatric Endocrinology by Sally Radovick

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Endocrine Replacement Therapy in Clinical Practice by A. Wayne Meikle

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Human Growth Hormone by Roy G. Smith

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