Human Molecular Genetics, Third Edition [Hardcover]

Tom Strachan (Author), Andrew Read (Author)

Book Description

ISBN-10: 0815341822 | ISBN-13: 978-0815341826 | Publication Date: November 21, 2003 | Edition: 3

Professors Tom Strachan & Andrew Read awarded the Education Award 2007 of the ESHG for their outstanding contribution to the dispersal of knowledge of modern human molecular genetics among students and professionals.

Following the completion of the Human Genome Project the content and organization of the third edition of Human Molecular Genetics has been thoroughly revised.

* Part One (Chapters 1-7) covers basic material on DNA structure and function, chromosomes, cells and development, pedigree analysis and the basic techniques used in the laboratory.
* Part Two (Chapters 8-12) discusses the various genome sequencing projects and the insights they provide into the organisation, expression, variation and evolution of our genome.
* Part Three (Chapters 13-18) focuses on mapping, identifying and diagnosing the genetic causes of mendelian and complex diseases and cancer.
* Part Four (Chapters 19-21) looks at the wider horizons of functional genomics, proteomics, bioinformatics, animal models and therapy.

There are new chapters on cells and development and on functional genomics. The sections on complex diseases have been completely rewritten and reorganized, as has the chapter on Genome Projects. Other changes include a new section on molecular phylogenetics (Chapter 12) and the introduction of 'Ethics Boxes' to discuss some of the implications of the new knowledge. Virtually every page has been revised and updated to take account of the stunning developments of the past four years since the publication of the last edition of Human Molecular Genetics.

Features:
* Integration of Human Genome Project data throughout the book
* Two new chapters 'Cells and Development' (Chapter 3) and 'Beyond the Genome Project: Functional Genomics, Proteomics and Bioinformatics' (Chapter 19)
* Completely rewritten and reorganised coverage of complex disease genetics
* Increased emphasis on gene function and on applications of genetic knowledge, including ethical issues
* More prominence given to novel approaches to treating disease, such as cell-based therapies, pharmacogenomics, and personalised medicine
* Special topic boxes that include detailed coverage of ethical, legal and social issues, including eugenics, genetic testing and discrimination, germ-line gene therapy and genetic enhancement, and human cloning
* Contains two indices: a general index and one that contains names of diseases and disorders

Supplements:

Art of HMG3 (CD-ROM) 0-8153-4183-0: £34.00

Editorial Reviews

Review

"This book is an excellent companion for students in human genetics or for researchers that want to gain background and knowledge in this field." (Human Genetics Journal)

From the Publisher

A complete, up-to-the-minute account of human molecular genetics from basic principles to current practice. Designed to engage and motivate students the text covers the organization, expression and evolution of the human genome. Features a comprehensive chapter on the latest progress in the Human Genome Project. --This text refers to an out of print or unavailable edition of this title.

See all Editorial Reviews

Product Details

• Hardcover: 696 pages
• Publisher: Garland Science/Taylor & Francis Group; 3 edition (November 21, 2003)
• Language: English
• ISBN-10: 0815341822
• ISBN-13: 978-0815341826
• Product Dimensions: 11.5 x 8.3 x 1.4 inches
• Shipping Weight: 3.7 pounds (View shipping rates and policies)
• Average Customer Review: 4.3 out of 5 stars  See all reviews (14 customer reviews)
• Amazon Best Sellers Rank: #105,409 in Books (See Top 100 in Books)
  • #76 in Books > Professional & Technical > Professional Science > Biological Sciences > Biology > Molecular Biology

Customer Reviews

Most Helpful Customer Reviews

7 of 7 people found the following review helpful:

5.0 out of 5 stars One of the best and most comprehensive books available on the subject, November 15, 2005

By 

T. Vogel "vogelt1" (nyc) - See all my reviews
(REAL NAME)   

This review is from: Human Molecular Genetics, Third Edition (Hardcover)

This book offers an up-to-date view of molecular genetics and the functional laboratroy tools and theories used to address various inherited disorders. The language is very approachable and the book is wonderfully cross-referenced. New developments in various computational fields are addressed and key websites are given for data analysis so that the interested reader can familiarize himself with these tools. I found this book very helpful for both an introduction and subsequent in depth analysis of various topics. The referenced articles are seminal papers and are a wonderful addition to yoour library. Highly recommended and essential for beginners in health professions, graduate students, and biomedical researchers.

3 of 3 people found the following review helpful:

5.0 out of 5 stars Get up to speed fast by reading this book, May 9, 2006

By 

Thomas P. Caruso "Playful Otter" (Blacksburg, VA USA) - See all my reviews
(REAL NAME)   

This review is from: Human Molecular Genetics, Third Edition (Hardcover)

Though I have been interested in molecular genetics for decades, I have been out-of-touch with the excitement in genetics that is percolating out of the huge amount of data coming from various genome sequencing projects. Want to know why there is so much excitement? Then I suggest you read this book.

The book is up-to-date not only with the latest information about what is happenning in molecular genetics, with a focus on human genetics, but also with the latest molecular biology methods needed to understand the field. Anyone with a basic biochemistry background could pick up this book and get a lot out of it, though the more statistics you know the better you will understand components on linkage analysis.

I plan to use this book as a reference for my developing research interests in this field. When I am reading a paper or after listening to a presentation, I can go right to the information in this book to refresh my knowledge about the method or general thinking about a particular topic. The book adds to this experience by providing key references for just about any related subject covered in the book in a more general fashion. I will be reading these references in specific areas close to my interest.

3 of 4 people found the following review helpful:

4.0 out of 5 stars Excellent reference for students and researchers., January 4, 2007

By 

Ryan W. Bonvillain (New Orleans, LA USA) - See all my reviews
(REAL NAME)   

This review is from: Human Molecular Genetics, Third Edition (Hardcover)

This book offers detailed insight into the fundamentals of human molecular genetics. The contents review DNA and chromosome structure and function, cellular development, population genetics, cancer genetics, gene therapy, and a myriad of molecular genetic techniques, applications, and analyses. The figures and illustrations beautifully complement the text with easily understood captions and legends. The organization of the book is such that the reader can easily find a topic of interest without thumbing through the entire text. I would highly recommend "Human Molecular Genetics" by Tom Strachan and Andrew P. Read to senior-level college students, graduate students, and researchers. This is a must-have in the library of any geneticist.