Hydrolases in Organic Synthesis: Regio- or Stereoselective Biotransformations [Hardcover]

Uwe Theo Bornscheuer (Author), Romas Joseph Kazlauskas (Author)

Book Description

Publication Date: June 18, 1999

An organic chemist considering the use of enzymes has to solve the problem of knowing which enzyme to use.
The focus of this book is, first, on the most useful enzymes - hydrolases. Second, it contains an extensive listing of the known applications. Organic chemists will be able to make reasonable choices by analogy. Third, it contains summaries of the structures of hydrolases and shows how these structures can rationalize the observed selectivities. This provides another way for chemists to choose hydrolases. Fourth, it contains experimental guidelines for how to use the hydrolases.
This book will get organic chemists (and enzymologists) started quickly in solving their synthetic problems.

Editorial Reviews

Review

"No library should be without the book."
Angewandte Chemie, F. Theil

From the Back Cover

U.T. Bornscheuer, R.J. Kazlauskas Hydrolases in Organic Synthesis Regio- and Stereoselective Biotransformations The most useful enzymes for synthesis are the hydrolases because of their ease of use and high stereoselectivity. Hydrolases are used commercially to produce food ingredients (e.g., aspartame, cocoa butter equivalents), agrochemical and pharmaceutical intermediates. This book surveys the stereoselective reactions of hydrolases, especially lipases, esterases and proteases. It gives researchers an overview of what has worked in the past so that researchers can get ideas on how to solve their synthetic problems. This book is intended for synthetic organic chemists who need an overview of possible reactions with hydrolases and their stereoselectivity. The book is organized first according to different synthetic problems (enantioselective reactions, regioselective reactions) and then according to the substrate structure (e.g. primary alcohols, carboxylates). It contains over a thousand chemical structures, so that the organic chemist can quickly locate reactions of interest.

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Product Details

• Hardcover: 352 pages
• Publisher: Wiley-VCH; 1 edition (June 18, 1999)
• Language: English
• ISBN-10: 3527301046
• ISBN-13: 978-3527301041
• Product Dimensions: 9.6 x 6.8 x 0.9 inches
• Shipping Weight: 1.8 pounds
• Amazon Best Sellers Rank: #6,787,409 in Books (See Top 100 in Books)

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