Customer Reviews

IImodium A_D Anti Diarrheal Value Size 48 count (Pack of 3)

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` This is an interesting item and well-priced here at Amazon, cheaper then other retailers and stores. This is also the 'tall-boy', coming in at 48 caplets of Loperamide Hydrochloride. I don't think Imodium comes in 96 caplet packs, but generic equivalents do(Equate and problably others).
Loperamide Hydrochloride, chemical name: 4-(p-chlorophenyl)-4-hydroxy-N,N-dimethyl-a,a-diphenyl-1-piperidinebutyramide, is chemically related to the piperadine-based narcotic Meperidine (brand name: Demerol). Demerol is a full-on opioid agonist that causes constipation and analgesia. Only the second Mu-Opiate Receptor is affected by Loperamide, the receptor responsible for producing opioids respiratory depression and constipation. Loperamide acts by slowing down the myenteric plexus (in English, the large intestine). Loperamide, however, does not break the Blood-Brain Barrier in sufficient quantities to cause euphoria or analgesia.
However, recent research has shown that when Loperamide is taken with Polysorbate 80 or Quinidine, the addition of P-glycoprotein inhibitors breaks the blood-brain-barrier (B/B/B) therefore causing Mu-Opioid receptor activation causing long lasting analgesia and euphoria. Insufflating Loperamide has also shown to aid in loperamide breaking into the B/B/B, although not as well as when taken with said inhibitors.
Upon being introduced this drug was a Schedule V substance because research showed after high doses being used for a long period of time caused minor withdrawals similar to that of other opioids. Now, Loperamide is available in any store without a prescription, and is not a scheduled substance. Non-approved uses include minor temporary physical relief of withdrawal symptoms caused by opioids such as Heroin, Oxycodone, Kratom and the like. This is also common with the use of Dextromethorphan HBr/Plsx, another "technical opioid" being the dextro salt of Levomethorphan.
The medication is only approved for relief of diarrhea and works very well, and provides long lasting relief. Loperamide helps ingestion problems and is widely used all over the world.
Just quick background info on Imodium AD, and its active ingredient Loperamide Hydrochloride (also sold as equivalent generics by Western Family, Equate, and other cheaper brands.) Hope this has been informative.