Diseases of the digestive system have a higher morbidity rate than any other group of disorder. There is a growing body of evidence that the immune system participates in the pathogenesis of a wide range of these diseases, including peptic ulcer disease and the gastropathy induced by nonsteroidal anti-inflammatory drugs (NSAIDS). For these reasons, efforts to develop novel therapies for digestive diseases are increasingly focused on the immune system. This volume reviews the immunopharmacology of the gastrointestinal tract at four distinct levels: Immunomodulation at a cellular level Cellular targers for immunomodulating drugs Specific classes of inflammatory mediators Utility and mechanisms of action of glucocorticoids in the treatment of diseases of the gastrointestinal tract.
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About the Author
JOHN M. WALLACE was born in New York in 1940. He received his Bachelor's degree from Webb Institute of Naval Architecture and his PhD from MIT, where he worked closely with Professors Victor P. Starr and Reginald E. Newell. He has been a member of the faculty of the Department of Atmospheric Sciences at the University of Washington since 1966. He has served terms as department chair, as Director of the Joint Institute of the Study of the Atmosphere and Ocean, and as Co-director of the University of Washington's Program on the Environment. His research interests include large scale atmospheric dynamics and climate variability and change. He regularly teaches an introductory graduate class in which this textbook is used.
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Inside This Book
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First Sentence:
The maintenance of the interior milieu and overall body integrity demands rapid and highly efficient systems for the detection of environmental changes and any potentially noxious agent, interpretation of the signals received and the elaboration of appropriate responses to avoid or otherwise deal with the challenge. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
leukocvte adherence, adhesive glycoprotein complex, cell monolavers, gastrointestinal capillaries, inflamed rat intestine, intestinal mucosal mast cells, gastric damage induced, postischemic intestine, intestinal lymph flow, ncutrophil adherence, mast cell populations, propria mononuclear cells, gastric ulceration induced, intraepithelial leucocytes, mast cell development, interstitial forces, intestinal anaphylaxis, mast cell functions, capillary filtration rate, gastric microcirculation, mucosal dysfunction, osmotic reflection coefficient, vascular protein leakage, mucosal injury induced, feline intestine Key Phrases - Capitalized Phrases (CAPs): (learn more)
New York, Natl Acad, Boca Raton, Agents Actions, Academic Press, Allergy Appl, Raven Press, Life Sci, The Neuroendocrine-Immune Network, Allergy Clin, Gastrointestinal Disease, Acta Phvsiol, Handbook of Physiology, Increased Increased, Ness York, Overview of Clinical Entity, Elsevier Science New!
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Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
The maintenance of the interior milieu and overall body integrity demands rapid and highly efficient systems for the detection of environmental changes and any potentially noxious agent, interpretation of the signals received and the elaboration of appropriate responses to avoid or otherwise deal with the challenge. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
leukocvte adherence, adhesive glycoprotein complex, cell monolavers, gastrointestinal capillaries, inflamed rat intestine, intestinal mucosal mast cells, gastric damage induced, postischemic intestine, intestinal lymph flow, ncutrophil adherence, mast cell populations, propria mononuclear cells, gastric ulceration induced, intraepithelial leucocytes, mast cell development, interstitial forces, intestinal anaphylaxis, mast cell functions, capillary filtration rate, gastric microcirculation, mucosal dysfunction, osmotic reflection coefficient, vascular protein leakage, mucosal injury induced, feline intestine Key Phrases - Capitalized Phrases (CAPs): (learn more)
New York, Natl Acad, Boca Raton, Agents Actions, Academic Press, Allergy Appl, Raven Press, Life Sci, The Neuroendocrine-Immune Network, Allergy Clin, Gastrointestinal Disease, Acta Phvsiol, Handbook of Physiology, Increased Increased, Ness York, Overview of Clinical Entity, Elsevier Science New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Citations (learn more)
This book cites 28
books:
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2
books
cite this book:
- The Effects of Immune Cells and Inflammation On Smooth Muscle and Enteric Nerves by William J. Snape Jr. on 4 pages
- Physiology of the Gastrointestinal Tract, Fourth Edition (v. 1-2) by Kim E. Barrett on page 50, page 91, and page 164
- Inflammation: Basic Principles and Clinical Correlates by John I. Gallin on page 37, page 64, and page 65
- Immunology and Immunopathology of the Liver and Gastrointestinal Tract by Stephan R. Targan on page 12, and page 14
- Clinical Gastrointestinal Physiology, 1e (Saunders Monograph in Physiology) by D. Neil Granger PhD on page 64
See all 28 books this book cites
- Probiotics 2: Applications and Practical Aspects (v. 2) by R. Fuller on page 156, page 157, and page 160
- Topical Steroids in Gastroenterology and Hepatology (Falk Symposium) by A. Dignass on page 3
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