This book reviews both genetic and biochemical data on the origin of genome instability and its impact on carcinogenesis. Reflecting recent discoveries and ongoing research, it discusses DNA repair mechanisms and hereditary cancer syndromes, as well as checkpoint mechanisms operating to safeguard chromosome integrity during cell cycle progression. Moreover, it summarises our current understanding of the various defects that may allow cancer cells to rapidly accumulate critical mutations and evolve, through processes reminiscent of Darwinian selection, an increasingly aggressive behaviour. Hopefully, this book will stimulate thought, discussion and experimentation, and serve as a rich source of information for a wide audience, including advanced students, researchers and clinical oncologists.
Genome Instability in Cancer Development
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Inside This Book
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First Sentence:
Human cancer cells contain large numbers of mutations. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
centrosome behaviour, multibranched chromosomes, centrosome doubling, amplified centrosomes, cell cycle checkpoint activation, multiradial chromosomes, pericentromeric rearrangements, centrosome amplification, mcm proteins, mitotic checkpoint proteins, mitotic checkpoint genes, juxtacentromeric heterochromatin, centrosome defects, condensin complex, tumour genome, telomere dysfunction, mitotic checkpoint control, poleward force, loading clamp, supernumerary centrosomes, centrosome cycle, nucleotide excision repair factors, checkpoint signalling, cohesin complex, dysfunctional telomeres Key Phrases - Capitalized Phrases (CAPs): (learn more)
Cancer Res, Genes Dev, Biol Chem, Mol Cell Biol, Proc Natl Acad Sci, Curr Biol, Nat Genet, Nucleic Acids Res, Proc Nall Acad Sci, Cell Sci, Genes Chromosomes Cancer, Proc Nail Acad Sci, Mol Biol Cell, Annu Rev Biochem, Mutat Res, Embo Rep, Murat Res, Exp Cell Res, Cancer Genet, Genes Cells, Curr Opin Genet Dev, Dev Cell, Genome Res, Nat Rev Cancer, New York New!
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Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Human cancer cells contain large numbers of mutations. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
centrosome behaviour, multibranched chromosomes, centrosome doubling, amplified centrosomes, cell cycle checkpoint activation, multiradial chromosomes, pericentromeric rearrangements, centrosome amplification, mcm proteins, mitotic checkpoint proteins, mitotic checkpoint genes, juxtacentromeric heterochromatin, centrosome defects, condensin complex, tumour genome, telomere dysfunction, mitotic checkpoint control, poleward force, loading clamp, supernumerary centrosomes, centrosome cycle, nucleotide excision repair factors, checkpoint signalling, cohesin complex, dysfunctional telomeres Key Phrases - Capitalized Phrases (CAPs): (learn more)
Cancer Res, Genes Dev, Biol Chem, Mol Cell Biol, Proc Natl Acad Sci, Curr Biol, Nat Genet, Nucleic Acids Res, Proc Nall Acad Sci, Cell Sci, Genes Chromosomes Cancer, Proc Nail Acad Sci, Mol Biol Cell, Annu Rev Biochem, Mutat Res, Embo Rep, Murat Res, Exp Cell Res, Cancer Genet, Genes Cells, Curr Opin Genet Dev, Dev Cell, Genome Res, Nat Rev Cancer, New York New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Citations (learn more)
This book cites 14
books:
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- United States of America (True Books: Geography: Countries) by Christine Petersen on page 192
- Prostate Cancer (Springer Series on Geriatric Nursing, 12) by Wallace on page 418
- CELL IN DEVELOPMENT & HEREDITY (Genes, Cells, and Organisms) by Edmund B. Wilson on page 420
- Breast Cancer (Chicken Soup for the Soul Healthy Living) by Jack Canfield on page 357
- Wtm USA (World Travel Map) by Collins on page 191
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