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An Introduction to Human Molecular Genetics: Mechanisms of Inherited Diseases [Hardcover]

Jack J. Pasternak (Author)
5.0 out of 5 stars  See all reviews (2 customer reviews)


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An Introduction to Human Molecular Genetics: Mechanisms of Inherited Diseases An Introduction to Human Molecular Genetics: Mechanisms of Inherited Diseases 5.0 out of 5 stars (2)
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Book Description

July 15, 1999 1891786032 978-1891786037 1st
With the explosion of new information from the Human Genome Project and new disease genes being identified at an extraordinary rate by laboratories around the world, the need for a scientifically sound and pedagogically refined text in Human Molecular Genetics has grown. This new text offers students and readers an extensive, up-to-date treatment of the genetic principles and fundamental molecular mechanisms that govern human inherited diseases. More than a catalogue of disease-related genes, this new text explains the interaction of genes and their products; the consequences of these mechanisms on disease states in major organ systems such as muscle, the nervous system, and the eyes; and cancer and mitochondrial disorders.

Praised by numerous reviewers for its timeliness and accuracy, An Introduction to Human Molecular Genetics is an ideal text for advanced undergraduate, early graduate, and basic medical school courses in human genetics. The book's lucid style and compelling coverage make it essential reading for all those who seek a better understanding of the fast moving field of Human Molecular Genetics.

From the Pre-publication Reviews
"A very well written and highly-detailed treatment of a very important area in genetics. It is very different from the traditional human genetics text, which is part of its appeal. The organization is prefect. The basic science chapters are gems, and the transition to inherited diseases of selected systems provides excellent flexibility. It would be easy to teach a course to advanced undergraduate, beginning graduate, and/or medical students using this new text." —Edward M. Berger, Dartmouth College

"I found it impressive how up-to-date the material is. It is current and at the right level for medical students, advanced undergraduates, and beginning graduate students." —John Hardy, Mayo Clinic

"Chapter one was beautifully written and quite informative. Chapter eight provides a really nice overview of the muscular dystrophies." —Louis Kunkel, Harvard Medical School, Howard Hughes Medical Institute


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Editorial Reviews

Review

"A fabulous textbook ... An outstanding contribution to genetics education." A Metzenberg, California State University, Northridge "A very well written and highly-detailed treatment of a very important area in genetics. It is different than the traditional human genetics text, which is part of its appeal ... The organisation is perfect. The basic science chapters are gems, and the transition to inherited diseases provides excellent flexibility. It would be easy to teach a course to advanced undergraduate, beginning graduate and/or medical students using this new text ..." Edward M Berger, Professor of Biology and Dean of the Faculty, Dartmouth College"Accurate and up-to-date ... The author presents concepts and examples in an interesting and informative manner and the chapters read well ... There is an excellent ratio of illustrative material to the written text." Don Nash, Colorado State University"I found it very impressive how up-to-date the material is .. It is current and at the right level for a medical student/undergraduate/early postgraduate text..." John Hardy, Mayo Clinic"..beautifully written and quite informative." Louis Kunkel, Harvard Medical School, Howard Hughes Medical Institute

From the Publisher

Engaging writing style and numerous illustrations make complex concepts accessible to all students. Chapter outlines, lists of key terms, extensive summaries of key concepts, and review questions are provided for each chapter.

Up-to-the-minute research and numerous references cited throughout.

"From the Human Genetics Files" sections in each chapter present historical and innovative applications and contributions of Human Molecular Genetics (like the use of DNA analysis to identify the remains of the Russian Imperial family).

Full-color insert illustrates the latest cytogenetic imaging techniques (FISH, SKY).


Product Details

  • Hardcover: 498 pages
  • Publisher: Wiley-Liss; 1st edition (July 15, 1999)
  • Language: English
  • ISBN-10: 1891786032
  • ISBN-13: 978-1891786037
  • Product Dimensions: 11.5 x 8.7 x 1.2 inches
  • Shipping Weight: 3.8 pounds
  • Average Customer Review: 5.0 out of 5 stars  See all reviews (2 customer reviews)
  • Amazon Best Sellers Rank: #2,768,754 in Books (See Top 100 in Books)

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5.0 out of 5 stars molecular genetics book, February 12, 2009
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Inside This Book (learn more)
First Sentence:
OF ALL LIVING ORGANISMS, only humans can learn to write, read, and understand this sentence. Read the first page
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
red opsin gene, green opsin genes, hybrid opsin, long template strands, flow diagram highlights, mutation detection assays, gene cloning approach, nonrecombinant chromosomes, nonrecombinant types, positional gene, cause protein truncation, human germ line gene therapy, proliferation signal transduction pathway, amyloid bodies, cell hybrid lines, multiple cloning sequence, doubly heterozygous parent, middle locus, somatic cell hybrid line, trinucleotide repeat expansion disorders, least frequent class, blue cone monochromacy, original cell lines, synaptic bulb, crossover chromatids
Key Phrases - Capitalized Phrases (CAPs): (learn more)
United States, Nature Genet, New York, Natl Acad, Gene Ther, Genetics of Cancer Syndromes, Genetics of Muscle Disorders, Genetics of the Eye, Genome Res, Unknown Autosomal, Unknown Unknown, Anna Anderson, Inheritance Autosomal, Progeny Genotypes, Alois Alzheimer, Charcot-Marie Tooth, Mol Genet, National Cancer Institute, Polymorphisme Humain, References Adams
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