An Introduction to Medicinal Chemistry [Paperback]

Graham L. Patrick (Author)

Book Description

Publication Date: May 3, 2001 | ISBN-10: 0198505337 | ISBN-13: 978-0198505334 | Edition: 2

This lively, highly illustrated text provides undergraduate and postgraduate students with an accessible introduction to medicinal chemistry. It covers basic principles and background, and then describes the general tactics and strategies involved in developing an effective drug. Through the use of numerous examples it highlights both the difficulties faced by the medicinal chemist and the great potential of rational drug design. The second edition has five new chapters and is updated to include recent advances in the field. Updated throughout with the latest descoveries
Five new chapters covering
* the molecular structure of receptors and the mechanisms of signal transduction
*combinatorial synthesis
* the role of computers in drug design
* adrenergics
* drug discovery and drug development

Editorial Reviews

Review

"Review from previous edition ...presents a complex subject in a clear, readable manner. In places, it even manages to be amusing."--New Scientist

About the Author

Graham L. Patrick, Lecturer in Chemistry, Paisley University.

Product Details

• Paperback: 646 pages
• Publisher: Oxford University Press, USA; 2 edition (May 3, 2001)
• Language: English
• ISBN-10: 0198505337
• ISBN-13: 978-0198505334
• Product Dimensions: 9.6 x 7.3 x 1.3 inches
• Shipping Weight: 2.5 pounds
• Average Customer Review: 4.0 out of 5 stars  See all reviews (6 customer reviews)
• Amazon Best Sellers Rank: #1,981,334 in Books (See Top 100 in Books)

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Customer Reviews

Most Helpful Customer Reviews

12 of 13 people found the following review helpful:

4.0 out of 5 stars A Good Very Basic Look at Medicinal Chemistry, January 25, 1999

By A Customer

This review is from: An Introduction to Medicinal Chemistry (Paperback)

This book is good in the sense that it is an easy read for anyone interested in the subject. The drawings and cartoons provide a bit of humor to the text and the writing is cloear and focused. The only drawback to the book is that the layperson does not get the full effect of the book without a very good grasp of biochemistry (hence the term layperson!). To get the real scope of the book, one would need to read a good Biochem text ( I personally suggest Lehninger, et. al. Principles of Biochemistry, 3rd ed.). A good pharmacological text would greatly enhance the reader's understanding of the subject as well (i.e. Goodman and Gilman's). Otherwise, the book does give a very brief, very good overview of many aspects of Medicinal Chemistry.

5 of 5 people found the following review helpful:

5.0 out of 5 stars Great Book, November 30, 2009

By 

G. Blette - See all my reviews
(REAL NAME)   

Amazon Verified Purchase

This review is from: An Introduction to Medicinal Chemistry (Paperback)

Bought the third edition for a class and I didnt even need this one but since I read the last edition I knew this would be good as well. So far I have not been disappointed and there is a good deal of information that was not in the last edition. This book is highly recommended.

1 of 1 people found the following review helpful:

5.0 out of 5 stars Outstanding book, January 3, 2012

By 

db - See all my reviews

Amazon Verified Purchase

This review is from: An Introduction to Medicinal Chemistry (Paperback)

I have never written a review before but this book has become a fixture in my life. It has become dog eared, marked up, highlighted, underlined - the works. To put this in perspective, I have a background and degree in computer science and am in a PhD program doing computational drug design. I had enough undergrad premed to be dangerous and to follow discussions, but my true strength was on the computational side. I bought this book to help me pick up my chemistry and biochemistry and, with all due humility, it worked like a charm. The explanations are clear and beautiful and, if you like this stuff, it's a page turner. Seriously. Yes, it is an introductory text. But man is it a good one. From here I have been able to move on to other graduate texts, contribute equally in my lab on the biochem front, and even had the opportunity to ask some questions of Christopher Lipinski (of Rule of Five fame) at a conference without embarrassing myself. If you are relatively new to drug design or medicinal chemistry or pharmacology and want to come up to speed quickly, and have at least, say, AP high school chemistry or maybe undergrad chemistry, particularly with at least one organic chem class, BUY THIS BOOK. I cannot say it enough. If you are in a position similar to mine, this book is outstanding. In the context of my degree program, maybe even life changing. The single best academic purchase I've made. Sorry to come off like a fan boy, but this book earned it. It's that good.