Introduction to Modern Liquid Chromatography [Hardcover]

Lloyd R. Snyder (Author), Joseph J. Kirkland (Author)

Book Description

Publication Date: October 1979 | ISBN-10: 0471038229 | ISBN-13: 978-0471038221 | Edition: 2

This Second Edition incorporates the latest developments in the practical application of LC. Covers the basic of LC, the six LC methods and their applications, and various specialized areas. Provides material for in-depth comprehension of how HPLC is performed, what the necessary materials are, and possible applications. Offers thorough treatment of such areas as quantitative and qualitative analysis by HPLC, preparative scale separations, gradient elution and column-switching, sample pretreatment and reaction detectors, automated systems for high-volume testing and/or samples requiring pretreatment, troubleshooting and sample artifacts, and selection and development of LC method for a particular applications.

Editorial Reviews

Review

?This book is a greatly expanded and revised edition of its predecessor.? (Analytical Biochemistry, 1981)

From the Back Cover

The latest edition of the authoritative reference to HPLC

High-performance liquid chromatography (HPLC) is today the leading technique for chemical analysis and related applications, with an ability to separate, analyze, and/or purify virtually any sample. Snyder and Kirkland's Introduction to Modern Liquid Chromatography has long represented the premier reference to HPLC. This Third Edition, with John Dolan as added coauthor, addresses important improvements in columns and equipment, as well as major advances in our understanding of HPLC separation, our ability to solve problems that were troublesome in the past, and the application of HPLC for new kinds of samples.

This carefully considered Third Edition maintains the strengths of the previous edition while significantly modifying its organization in light of recent research and experience. The text begins by introducing the reader to HPLC, its use in relation to other modern separation techniques, and its history, then leads into such specific topics as:

• The basis of HPLC separation and the general effects of different experimental conditions

• Equipment and detection

• The column—the "heart" of the HPLC system

• Reversed-phase separation, normal-phase chromatography, gradient elution, two-dimensional separation, and other techniques

• Computer simulation, qualitative and quantitative analysis, and method validation and quality control

• The separation of large molecules, including both biological and synthetic polymers

• Chiral separations, preparative separations, and sample preparation

• Systematic development of HPLC separations—new to this edition

• Troubleshooting tricks, techniques, and case studies for both equipment and chromatograms

Designed to fulfill the needs of the full range of HPLC users, from novices to experts, Introduction to Modern Liquid Chromatography, Third Edition offers the most up-to-date, comprehensive, and accessible survey of HPLC methods and applications available. --This text refers to an alternate Hardcover edition.

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Product Details

• Hardcover: 896 pages
• Publisher: Wiley-Interscience; 2 edition (October 1979)
• Language: English
• ISBN-10: 0471038229
• ISBN-13: 978-0471038221
• Product Dimensions: 9.4 x 6.3 x 2.1 inches
• Shipping Weight: 2.9 pounds (View shipping rates and policies)
• Average Customer Review: 5.0 out of 5 stars  See all reviews (4 customer reviews)
• Amazon Best Sellers Rank: #2,077,069 in Books (See Top 100 in Books)
  • #48 in Books > Professional & Technical > Professional Science > Chemistry > Chromatography

Customer Reviews

Most Helpful Customer Reviews

2 of 2 people found the following review helpful:

5.0 out of 5 stars This book is impressive., October 2, 2011

By 

D. Miyao (San Diego) - See all my reviews
(REAL NAME)   

Amazon Verified Purchase

This review is from: Introduction to Modern Liquid Chromatography (Hardcover)

I am a high throughput chemist at a biotech and purify my own samples. I have been running my own HPLC mass spec for 5+ years and recently bought this book and have been pretty successful at running my instrument. This book is good for understanding chromatography, but it is also good for actual methods in the lab. This book contains enough information to fill a college course for a semester or maybe even two semesters. I highly recommend this book.

4 of 5 people found the following review helpful:

5.0 out of 5 stars They never dissapoint, February 4, 2010

By 

Crystal Thomas "at2002" (Cambridge, MD USA) - See all my reviews
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Amazon Verified Purchase

This review is from: Introduction to Modern Liquid Chromatography (Hardcover)

I have an older edition of this book, and I bought this one primarily because I was using it as a reference in a paper and wanted the most up to date version. I thought: how different could it be? Answer: I've already changed some techniques, ideas as a result of what I've read.

Pros: well organized

clearly written

very informative-lots of information for anyone new to chromatography, and for experienced chromatographers

I love these guys!

4 of 6 people found the following review helpful:

5.0 out of 5 stars The Bible for the Chromatographer, March 31, 2003

By 

F. Pallas (Sonoma County, CA United States) - See all my reviews
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This review is from: Introduction to Modern Liquid Chromatography (Hardcover)

Introduction to Modern Liquid Chromatography - This book is a must for anyone practicing liquid chromatography. It is a great resource for both the novice and experienced chemist. Highly recommended.