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Introduction to Population Pharmacokinetic / Pharmacodynamic Analysis with Nonlinear Mixed Effects Models Hardcover – July 8, 2014

ISBN-13: 978-0470582299 ISBN-10: 0470582294 Edition: 1st

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Frequently Bought Together

Introduction to Population Pharmacokinetic / Pharmacodynamic Analysis with Nonlinear Mixed Effects Models + Pharmacokinetic-Pharmacodynamic Modeling and Simulation + Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Fourth Edition
Price for all three: $381.46

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Editorial Reviews

Review

“This book may make the “User Guide V experience” a story from the good old times for the next generation of pharmacometricians.”  (CPT: Pharmacometrics & Systems Pharmacology, 22 December 2014)

From the Back Cover

A Guide to the Most Powerful Tool for Population Pharmacokinetic / Pharmacodynamic Analysis

Population pharmacokinetic / pharmacodynamic analysis using Nonlinear Mixed Effects Modeling (NONMEM) is an approach that has gained substantial importance in pharmacometrics. NONMEM is the primary tool employed and is the keystone in novel initiatives on quantitative model-based drug development led by the US FDA, professional organizations, and the pharmaceutical industry

This book uses a hands-on approach to introduce all aspects of NONMEM, how to use the system, and the concepts behind specific methods. As a didactic tool, it gives the reader an overview and provides critical information, including:

  • Fundamentals: Population model concepts and terminology
  • Requisite concepts for using NONMEM: writing control streams, model building, and evaluation aspects
  • Examples of nonlinear modeling concepts and estimation basics with discussion on Bayesian analysis and PK/PD modeling
  • Guidelines on data set requirements and structures, interpretation of the output, simulation using NONMEM, and quality control of pharmacometric anlayses

This book also features a supplementary website with datasets, programming code, and exercises and solutions to provide readers with a practical understanding of population modeling. The authors are leading scientists with real-world experience who bring their critical thinking and problem solving perspectives together in this user-friendly guidebook.

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Introduction to Population Pharmacokinetic / Pharmacodynamic Analysis with Nonlinear Mixed Effects Models
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