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Introduction to Protein Structure 2nd Edition

19 customer reviews
ISBN-13: 978-0815323051
ISBN-10: 0815323050
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About the Author

Carl Branden was educated at Uppsala University (PhD) and the MRC Laboratory for Molecular Biology, Cambridge, where he was a postdoctoral fellow in the laboratory of J.C. Kendrew. He has pursued a career in basic research, science administration (as science advisor to the Swedish Government), and biotechnology. Formerly Research Director of the European Synchrotron Radiation Facility in Grenoble, France, he is now at the Microbiology and Tumor Biology Center at the Karolinska Institute in Stockholm. A protein crystallographer with a distinguished academic career in research and teaching, he has made major contributions to the understanding of many biological structures, and is an editor of Structure.

John Tooze was educated at Cambridge University (MA), London University (PhD) and Harvard University (where he was a postdoctoral fellow in the laboratory of J.D. Watson). After several years in basic research, he moved principally into science administration and science publishing, notably as the executive secretary of the European Molecular Biology Organisation, Heidelberg, Germany. He is currently Director of Support Services at the Imperial Cancer Research Fund Laboratories, London, and editor of EMBO Journal. A molecular biologist, his previous books include Molecular Biology of Tumor Viruses, The DNA Story (with J.D. Watson) and the very successful first edition of Recombinant DNA: A Short Course (with J.D. Watson and D.T. Kurtz).

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Product Details

  • Paperback: 410 pages
  • Publisher: Garland Science; 2 edition (January 3, 1999)
  • Language: English
  • ISBN-10: 0815323050
  • ISBN-13: 978-0815323051
  • Product Dimensions: 10.9 x 8.4 x 0.7 inches
  • Shipping Weight: 1.4 pounds (View shipping rates and policies)
  • Average Customer Review: 4.6 out of 5 stars  See all reviews (19 customer reviews)
  • Amazon Best Sellers Rank: #60,219 in Books (See Top 100 in Books)

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38 of 39 people found the following review helpful By A Customer on February 28, 2001
Format: Paperback
This book does a great job in introducing all the various nuances of protein structure. Throughout the book specific examples of proteins are given that exhibit features described in the text. One thing that makes the book especially instructive is the large number of illustrations used to explain key points. Usually a motif or domain was illustrated in ribbon schematics as well as with topology diagrams, making it easy to see connectivity within protein structures. I have been working as a protein biochemist for the past several years and recommend this book highly.It is appropriate both for experienced scientists who might want a refresher, or for a beginner who needs a firm foundation in protein structure.
One small thing I encountered several times in the book was redundant sentences, as if the editors missed some things periodically. This is hardly worth mentioning, and did not detract from the overall usefulness of the book.
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27 of 29 people found the following review helpful By wiredweird HALL OF FAMETOP 1000 REVIEWER on September 21, 2003
Format: Paperback
This book was a pleasant surprise in almost every respect. I found it a gentle, clear exposition of material that can be hugely complicated. The text works upwards from amino acids, the building blocks, through the interactions of shape and chemical affinity, to views of proteins in action. By the time they appear, muscle fibers and virus capsules follow naturally from the discussion. This gives simple, concise descriptions of how proteins' shape emerge from its sequence. It goes on to describe protein control of DNA, to explain virus and muscle structure, and to hint at modern drug design.
'Protein Structure' requires some background in organic chemistry and in the ideas of molecular genetics. For example, you should already be familiar with steric hindrance and with the idea of regulatory regions in DNA. Branden and Tooze reward the prepared reader with a well-considered series of discussions. These include enzyme action, photosynthesis, virus self-assembly, muscle fibers, DNA binding, and more. I had never seen an actual chain of chemical events that turn light into usable chemical energy. This book stepped through it (for a bacterium, at least) in just few paragraphs and drawings. But the whole book is like that - it sustains a remarkable density of information, always in a very readable style.
The text is laid out in a simple and appealing way, and is profusely illustrated. The illustration is one of this book's wonderful strengths. Almost all of the discussion is carried in diagrams as well as in words, and the authors freely use as many different diagrams as needed to make each idea understandable. The illustration style is simple and consistent; most drawings use one of three or four conventions for describing proteins.
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13 of 13 people found the following review helpful By Emmeliana Huxley on July 8, 2003
Format: Paperback
If you are looking for a basic introduction to proteins and their form and function--or if you are looking for a good text to review protein chemistry--there is none better than Branden and Tooze. I have a Ph.D. in biochemistry, and routinely reccommend this book to everyone from undergraduate students taking biochemistry to graduate students and professors looking to review knowledge they've forgotten. This book has the perfect combination of clear explanations in ordinary english (rather than in complicated jargon) and full-color, easy to interpret diagrams. I fully intend to buy a second copy, since my current copy is perpetually on loan to friends/students. Buy two for yourself!
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15 of 17 people found the following review helpful By A Customer on January 16, 2002
Format: Paperback
I used this book for an class in structural biology. I really liked the book because it went into alot of detail about each aspect of protein structure and the drawings were very pertinent to the text. The language is not too technical, so if you don't know much about proteins, you can start from the beginning and not have a problem understanding. They take you through the jargon slowly, so that by the end of the book, you've learned alot and can probably read a journal article in this field.
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9 of 10 people found the following review helpful By Thomas J. Dougherty on January 21, 2004
Format: Paperback
This review refers to the second edition of this book, issued in 1999. The book, written by a noted crystallographer (Branden) and a molecular biologist (Tooze) noted for science education. Following up on an earlier edition, the present volume takes advantage of the enormous increase in solved protein structures that has occurred in the intervening years. The book is well written, clear, and makes excellent use of contrasting pastel colors to represent three-dimensional objects (proteins) on a two-dimensional page. One rather surprising omission is the lack of stereo views of proteins in a book about structure. These have become quite common in the structural biology literature, and I feel the book would have been strengthened by judicious inclusion of some examples.
The book, which would be suitable for an advanced undergraduate, graduate course or for biologist wishing to delve more into structure, begins with basic amino acid properties. The secondary structure elements of alpha helix and beta sheet are next introduced, along with some of the conventions used to illustrate structure in publications. How these structural elements are formed to build motifs, and motifs in turn are built into complex structures is discussed. Protein folding and flexibility are discussed, and proteins that assist in the process (e.g., chaperones, GroEL-GroES, disulfide isomerases) are highlighted.
The next several chapters deal with DNA structure, DNA recognition by helix-turn-helix motifs, and eukaryotic transcription factors. The various transcription factor families are outlined, with emphasis on their interactions with DNA. Next, the subject of enzyme catalysis is covered, using serine proteases as exemplars.
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