"[This text deserves] serious attention from any quantitative scientist or physicist who hopes to learn about modern biology. [It is] well written. … Alon’s book is the better place for physicists to start. It assumes no prior knowledge of or even interest in biology. Yet right from chapter 1, the author succeeds in explaining in an intellectually exciting way what the cell does and what degrees of freedom enable it to function. … The book proceeds with detailed discussions of some of the key network motifs, circuit-element designs … [and] focuses on concrete examples such as chemotaxis and developmental pattern formation. … He draws the detailed strands together into an appealing and inspiring overview of biology. … One final aspect that must be mentioned is the wonderful set of exercises that accompany each chapter. … Alon’s book should become a standard part of the training of graduate students in biological physics… ."
—Nigel Goldenfeld, University of Illinois at Urbana-Champaign, Physics Today, June 2007
"…a superb, beautifully written and organized work that takes an engineering approach to systems biology. Alon provides nicely written appendices to explain the basic mathematical and biological concepts clearly and succinctly without interfering with the main text. He starts with a mathematical description of transcriptional activation and then describes some basic transcription-network motifs (patterns) that can be combined to form larger networks. … Alon investigates networks at a higher level, including genomic regulatory networks. He does an excellent job of explaining and motivating a useful toolbox of engineering models and methods using network-based controls. … will be a valuable and non-overlapping addition to a systems-biology curriculum."
—Eric Werner, Department of Physiology, Anatomy and Genetics, University of Oxford, Nature, Vol. 446, No. 29, March 2007
"I read Uri Alon’s elegant book almost without stopping for breath. He perceives and explains so many simple regularities, so clearly, that the novice reading this book can move on immediately to research literature, armed with a grasp of the many connections between diverse phenomena."
—Philip Nelson, Professor of Physics, University of Pennsylvania, Philadelphia, USA
"… Beyond simply recounting recent results, Alon boldly articulates the basic principles underlying biological circuitry at different levels and shows how powerful they can be in understanding the complexity of living cells. For anyone who wants to understand how a living cell works, but thought they never would, this book is essential."
—Michael B. Elowitz, California Institute of Technology, Pasadena, USA
"Uri Alon offers a highly original perspective on systems biology, emphasizing the function of certain simple networks that appear as ubiquitous building blocks of living matter. The quest for simplicity — without losing contact with complex reality — is the only way to uncover the principles organizing biological systems. Alon writes with uncommon lucidity…"
—Boris Shraiman, University of California, Santa Barbara, USA
"This is a remarkable book that introduces not only a field but a way of thinking. Uri Alon describes in an elegant, simple way how principles such as stability, robustness and optimal design can be used to analyze and understand the evolution and behavior of living organisms. Alon’s clear intuitive language and helpful examples offer — even to a mathematically naive reader — deep mathematical insights into biology. The community has been waiting for this book; it was worth the wait."
—Galit Lahav, Harvard Medical School, Boston, Massachusetts, USA
As a graduate student of systems biology I found this book very useful and I highly recommend it!
This book looks at biology from the perspective of how genes and proteins interact at a network level, rather than a chemical level.
The language of the book is very clear and the math is very simple, with both the math and the biology beautifully written.
There were several times during my first reading of this book when my jaw literally dropped at how cool biological systems are. Read morePublished 8 months ago by Dave Morris
I come from a Biological background and have a deep interest in Systems Biology. I didn't find the book particularly difficult to get through but it can be dry at times (would you... Read morePublished 11 months ago by Rico Suave
The book is easy to understand and detailed, but the questions always make me confused about what it's asking for.Published 18 months ago by Will
So I haven't read the whole thing yet (just the first few chapters) but as a chemist/biologist who has had NO experience whatsoever with systems biology, I think this book is... Read morePublished on March 5, 2012 by Mike457
Watch out, the e-book version doesn't work on kindle fire as of today! For this reason alone, I'm only giving it 1 star, and yes, I'm very pissed off.Published on February 4, 2012 by S. Liu
There are a number a books on systems biology out there and the majority seem hastily put together during the past couple of years just to ride the wave of the systems biology buzz... Read morePublished on February 12, 2010 by Marshall
I'm a professor in molecular biology and wanted to learn more about networks so I could begin to apply it in my research. Read morePublished on December 4, 2009 by Donald J. DEGRACIA
This is a great and well written book, a milestone in the field. I use this book as part of the course material for my courses in "Systems Biology" and "Biological Networks" at... Read morePublished on August 28, 2009 by D. Peer
This is an excellent textbook for systems biology. I have used it two times. One is a short course of systems biology in the summer 2008 for some professors who are interested in... Read morePublished on August 13, 2009 by Bor-Sen Chen