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Invisible Frontiers: The Race to Synthesize a Human Gene [Paperback]

Stephen Hall (Author), James Watson (Contributor)
5.0 out of 5 stars  See all reviews (1 customer review)


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Book Description

April 11, 2002
From the spring of 1976 to the fall of 1978, three laboratories competed in a feverish race to clone a human gene for the first time, a feat that ultimately produced the world's first genetically engineered drug--the life-sustaining hormone insulin. Invisible Frontiers gives us a behind-the-scenes look at the three main groups at Harvard University, the University of California-San Francisco, and a team of upstart scientists at Genentech, the first company devoted to the use of genetic engineering in the creation of pharmaceuticals. When the dust had settled, one scientist had won a Nobel Prize, many others had become biotech's first millionaires, and the key technologies were in place that set the stage for the human genome project. Author Stephen Hall weaves together the scientific, social and political threads of this story--the fierce rivalry between labs, the fateful clash of egos within labs, the invasion of academia by commerce, the public fears about genetic engineering, the threat of government regulation, and the ultimate triumph of modern biology--to give us an outstanding tale of scientific research.
In this fast-paced, gripping narrative Hall captures the highlights--and high jinks--of one of the greatest eras in recent biological history: the discovery of recombinant DNA and the birth of biotechnology.


Editorial Reviews

From Publishers Weekly

Drawing on scores of interviews with participants, science writer Hall describes the 19761978 "race"begun when the pharmaceutical giant Eli Lilly organized a recombinant DNA symposium of scientists in Indianapolisbetween a Harvard biogenetics lab, headed by scientist Walter Gilbert, and two San Franciscoarea labs, one calling itself City of Hope (eventually funded by a tiny company called Genentech) and the other a William Rutter-Howard Goodman team ultimately backed by Eli Lilly. The goal: to make insulin in mass-market quantities by using recombinant DNA techniquessplicing a human gene with bacteria. This is demanding reading for biochemistry novices, but the drama is double-track: scientists plus entrepreneurs. In late 1978, the City of Hope team won out ("the bacteria went bonkers"), while the unlucky Harvard/Biogen lab found gremlins in its "soup." A new era of Big Buck science? The jury is still out. First serial to California magazine.
Copyright 1987 Reed Business Information, Inc. --This text refers to an out of print or unavailable edition of this title.

From Library Journal

During the later 1970s research on recombinant DNA and bacterial cloning of human genes was at the center of "Big Amazing Science." Recognition by peers, Nobel prizes, and lucrative pharmaceutical contracts drove ambitious scientists in a feverish competition, and two major biotechnology firms emergedBiogen and Genentech. Through interviews with the participants, Hall has assembled a story of science at the cutting edge, and especially of the personalities involvedtheir motivations, their philosophies. While the cloning of human insulin and somatostasin has established Genentech as a near billion dollar enterprise, the commercial and social impact of this research is yet to be determined. To be read for the human interest side of the story. Walter P. Coombs, Jr. Biology Dept., Western New England Coll., Springfield, Mass.
Copyright 1987 Reed Business Information, Inc. --This text refers to an out of print or unavailable edition of this title.

Product Details

  • Paperback: 352 pages
  • Publisher: Oxford University Press, USA (April 11, 2002)
  • Language: English
  • ISBN-10: 0195151593
  • ISBN-13: 978-0195151596
  • Product Dimensions: 7.7 x 5.7 x 0.7 inches
  • Shipping Weight: 9.8 ounces
  • Average Customer Review: 5.0 out of 5 stars  See all reviews (1 customer review)
  • Amazon Best Sellers Rank: #1,190,082 in Books (See Top 100 in Books)

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2 of 2 people found the following review helpful:
5.0 out of 5 stars A really enjoyable book and a must read for biologists., August 31, 2004
This review is from: Invisible Frontiers: The Race to Synthesize a Human Gene (Paperback)
Great success comes only after overcoming great difficulties. Basically this fact of life underlies this book. The fascinating point is, it is not an account of life of some great sportsman or some great leader but of a group of those people in society called scientists whose curious minds, hard work and vision helped emergence of Biotechnology as a major branch of science as well as industry in a relatively short time and in turn gave them recognition as great scientists. Were they great industrialists too? You can try to find that out in this book. Their efforts were also a major help for studies on gene function. This is a true exciting account of a thrilling race between three groups interested in cloning the first gene! It impressively shows not only the competition among the scientists but also their struggle with the bureaucracy. In this book one can see the life of scientists who are in true sense dedicated to science (though it doesn't mean that all the laboratories function the same way!). Another interesting aspect, which this book brings about, is the way basic academic research and industry is bridged and choice to walk on that bridge (in either direction) is not always easy for scientists.

Writer Stephen Hall has done a wonderful job in bringing `life in science' in front of a common man.
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Inside This Book (learn more)
First Sentence:
It was not a seminal meeting, at least not in the usual sense of the word. Read the first page
Key Phrases - Capitalized Phrases (CAPs): (learn more)
San Francisco, Wally Gilbert, City of Hope, Herb Boyer, Axel Ullrich, Eli Lilly, Bio Labs, Walter Gilbert, Bob Swanson, Art Riggs, Forrest Fuller, John Shine, Dennis Kleid, Howard Goodman, United States, West Coast, Keiichi Itakura, Lydia Villa-Komaroff, Herb Heyneker, Midnight Hustler, National Academy, Arg Efstratiadis, Argiris Efstratiadis, Irving Johnson, Peter Seeburg
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