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Ion Channels: From Atomic Resolution Physiology to Functional Genomics (Novartis Foundation Symposia)
 
 
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Ion Channels: From Atomic Resolution Physiology to Functional Genomics (Novartis Foundation Symposia) [Hardcover]

Novartis Foundation (Author)

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Book Description

0470843756 978-0470843758 June 24, 2002 1
Ion channels provide a unique opportunity to use computational approaches to attempt an understanding of the function of a membrane protein, starting with an atomic resolution structure and progressing through a hierarchy of theoretical descriptions until one can account quantitatively for their physiological function. This book brings together physiologists, structural biologists and theorists who came together to help define the direction of the field in the immediate future.
Topics covered include:
* the x-ray structure of channels and pores
* computer simulation of channel function
* detailed data on potassium channels, chloride and calcium channels, and ligand-gated ion channels

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Editorial Reviews

Review

"…I would particularly recommend it to students who wish to gain a flavour of the discussions, disputes and personalities within this field…" (The Biochemist, 31 March 2003)

From the Back Cover

Ion channels are a diverse class of transmembrane proteins responsible for rapid passive movement of selected ions across cell membranes. They play a crucial role in regulating diverse cell functions in both electrically excitable and non-excitable cells, and have been found in organisms ranging from viruses and bacteria to plants and mammals. An increasing number of diseases are associated with dysfunction of ion channels. In particular, many human neurological and muscular disorders have been traced to defects in voltage-gated and ligand-gated ion channels. Furthermore, ion channels provide paradigms for other, possibly more complex, membrane transport proteins. In this respect, they present an almost unique opportunity to use computational approaches to attempt to understand the function of membrane proteins, starting with an atomic resolution structure and progressing through a hierarchy of theoretical descriptions until one can account quantitatively for their physiological function. This important book results from a meeting of physiologists, structural biologists and theorists who came together to discuss their work and help define future directions. Topics covered include the X-ray structure of channels and pores, computer simulation of channel function, and detailed data on individual ion channels.

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Inside This Book (learn more)
First Sentence:
Abstract. The structure of the acetylcholine-gated channel, trapped in open as well as closed states, has been analysed by electron crystallographic methods. Read the first page
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
second site suppressor analysis, atomic resolution physiology, gating equilibrium, cytoplasmic vestibule, filter energetics, conformational wave, single file waters, permeation energetics, gating reaction, transmitter binding sites, default geometry, extracellular vestibule, ion permeation pathway, proteolipid complex, energy restraint, narrowest constriction, cytoplasmic membrane surface, dehydration energy, activation gating, neuronal nicotinic receptors, aquaporin family, pore axis, pore domain, shaker potassium channel, activated conformation
Key Phrases - Capitalized Phrases (CAPs): (learn more)
Biol Chem, Mol Biol, Proc Natl Acad Sci, Nat Struct Biol, New York, Nigel Unwin, Morais Cabral, Chem Phys, Phys Chem, Trends Biochem Sci, Annu Rev Biophys Biomol Struct, Biochim Biophys Acta, Biol Sci, National Institutes of Health, Soc Lond, Benoit Roux, Curr Opin Struct Biol, Mol Pharmacol, Philos Trans, Physiol Rev, Receptors Channels, References Aggarwal, Titia Sixma
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