The book consists of 14 chapters covering epidemiology, risk factors and their control, differential diagnosis, and the diverse clinical manifestations of cerebral ischemia. There are excellent, brief discussions of the role of diagnostic testing, including magnetic resonance imaging, computed tomography, positron-emission tomography, single-photon-emission computed tomography, conventional angiography, digital-subtraction angiography, ultrasonography, and other noninvasive methods of studying the cerebral circulation. The chapter on cardiac sources of embolism includes a thoughtful analysis of risk factors and covers the management of atrial fibrillation and nonthrombotic causes of embolism. The noninflammatory vasculopathies (including arterial dissection and moyamoya disease) and the inflammatory vasculopathies (including cerebral vasculitis) are well summarized. A chapter on stroke in children and young adults covers genetic factors and is of special interest. A chapter on prothrombotic states concisely covers disorders of plasma proteins, including antiphospholipid antibodies and lupus anticoagulant, and the role of these disorders in inducing the prothrombotic state.
There are detailed discussions of medical and surgical therapy for stroke prevention, and balanced views of the controversial issues involved, such as those surrounding anticoagulation and carotid surgery, are presented. The medical management of acute ischemic stroke is covered particularly well; topics presented include the organization of a stroke service and the outcome of patients so hospitalized. The book ends with a review of rehabilitation services and their role in patients' recovery.
There are more than 4000 references in this book, as well as many tables that summarize recent controlled clinical studies that have changed patient care. This book does not deal with ischemia in terms of experimental pathophysiology and biochemistry; rather, it is a guide for clinical practitioners. I hope the authors will write a companion book on the care of patients with hemorrhagic stroke, one that provides an analogous summary of the recent advances made in this other important population of patients with stroke. This concise, authoritative textbook is strongly recommended to physicians who wish to optimize the care of patients with stroke.
Robert A. Fishman, M.D.
Copyright © 2002 Massachusetts Medical Society. All rights reserved. The New England Journal of Medicine is a registered trademark of the MMS.
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