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  • Jarrow Formulas SAM-e, 200 mg, 60 Count
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Jarrow Formulas SAM-e, 200 mg, 60 Count

by Jarrow
| 5 answered questions

List Price: $39.95
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60
  • Enteric-Coated
  • Central biochemical building block
  • 68-80% Active S,S Form
  • Made Naturally By Fermentation
  • Individually Blister-Packed

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Frequently Bought Together

Jarrow Formulas SAM-e, 200 mg, 60 Count + Jarrow Formulas SAM-e, 400 mg, 30 Count + Jarrow Formulas Ubiquinol  QH-Absorb, 100 mg, 120 Count
Price for all three: $87.10

Buy the selected items together



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Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. Please see our full disclaimer below.

Product Description

Size: 60

Product Description

Product Profile

S-adenosyl-L-methionine (SAM-e) is an amino acid derivative clinically documented to benefit brain, liver and joint function.* Found in all living cells, SAM-e is called “activated methionine” and is formed via combination of ATP with methionine. Somewhat counterintuitively, however, methionine supplementation does not elevate SAM-e levels in the body. Rather, it elevates problematic homocysteine. SAM-e has undergone many clinical trials involving thousands of human subjects. Researchers have identified many structure- and function-based benefits of SAM-e involving over 40 biochemical processes. It is a biochemical workhorse with various diverse effects on the body, including improving liver function, supporting joint health and lifting mood.*


Distinguishing Features:

  • Predominantly active S,S form
  • Produced naturally via fermentation
  • Processed without solvents
  • Protected from degradation by enteric coating & blister-packaging
  • Preserved bioavailability through low-temp & low-moisture manufacturing
Liver Detoxification And Brain Function

SAM-e metabolism supports glutathione (GSH) synthesis and glutathione-dependent enzymes, which support liver function.* GSH, the chief antioxidant and detoxifier inside cells, scavenges free radicals produced during carbohydrate breakdown for energy. Taurine is another end product of SAM-e metabolism. GSH and taurine are important for liver detoxification.*

SAM-e supports brain function by its methylation effects.* Methylation is the transfer of a methyl group (one carbon and three hydrogen atoms, CH3) from one molecule to another. SAM-e is the most important of all methyl-donors in mammalian metabolism. Donation of methyl groups supports numerous metabolic processes including brain function, energy production, and DNA metabolism. Neurotransmitters, substances involved in nerve cell communication, are also products of methylation. These compounds include L-DOPA, dopamine, serotonin, epinephrine, and phosphatidylcholine (in lecithin). SAM-e is thought to benefit cognitive health by supporting the production of such critical brain messengers.* In fact, many people report noticeable positive effects on brain and mood after only taking it for a short time.*

Not All SAM-e Is Created Equal

SAM-e exists in two forms: (S,S) SAM-e and (R,S) SAM-e. The biologically active form is the (S,S) structure, while the (R,S) structure is inactive. Jarrow Formulas SAM-e is predominantly the active form. It is made naturally by microbiological fermentation and then specially processed, without solvents, to preserve 68-80% (S,S) SAM-e, the highest active level available.

SAM-e is a highly reactive molecule and very fragile. It degrades rapidly under high heat or humidity. Improper handling of SAM-e can cause degradation in a matter of hours. Thus, the manufacturing process for Jarrow Formulas SAM-e is done under low temperature and low humidity, and the tablet is enteric coated and blister-packed. Studies show that oral supplementation of SAM-e is most effective when enteric-coated by special gastric fluid-resistant polymers, resulting in maximum blood levels.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Amazon.com

Jarrow Formulas SAM-e 200, 200mg, 60 Tablets
At a Glance:
  • Contributes to the proper functioning of many biochemical systems
  • Ideal for those wanting to optimize cognitive function, mood, energy levels, liver activity and joint health*
  • Preserved bioavailability through low-temp and low-moisture manufacturing
  • Processed without solvents
  • Protected from degradation via enteric coating and blister-packaging
Jarrow Formulas SAM-e 200, 200mg, 60 Tablets Product Shot

SAM-e contributes to the proper functioning of many biochemical systems.

Jarrow Formulas SAM-e 200, 200mg, 60 Tablets Product Shot

S-adenosyl-L-methionine (SAM-e) is an amino acid derivative clinically documented to benefit brain, liver and joint function*. View larger.

Vegan
The Multi-Functional Supernutrient

S-adenosyl-L-methionine (SAM-e) is an amino acid derivative clinically documented to benefit brain, liver and joint function.* Found in all living cells, SAM-e is called "activated methionine" and is formed via combination of ATP with methionine. Somewhat counterintuitively, however, methionine supplementation does not elevate SAM-e levels in the body. Rather, it elevates problematic homocysteine.

SAM-e has undergone many clinical trials involving thousands of human subjects. Researchers have identified many structure- and function-based benefits of SAM-e involving over 40 biochemical processes. It is a biochemical workhorse with various diverse effects on the body, including improving liver function, supporting joint health and lifting mood.*

Liver Detoxification

SAM-e metabolism supports glutathione (GSH) synthesis and glutathione-dependent enzymes, which support liver function.* GSH, the chief antioxidant and detoxifier inside cells, scavenges free radicals produced during carbohydrate breakdown for energy. Taurine is another end product of SAM-e metabolism. GSH and taurine are important for liver detoxification.*

Brain Function

SAM-e supports brain function by its methylation effects.* Methylation is the transfer of a methyl group (one carbon and three hydrogen atoms, CH3) from one molecule to another. SAM-e is the most important of all methyl-donors in mammalian metabolism. Donation of methyl groups supports numerous metabolic processes including brain function, energy production and DNA metabolism. Neurotransmitters, substances involved in nerve cell communication, are also products of methylation. These compounds include L-DOPA, dopamine, serotonin, epinephrine and phosphatidylcholine (in lecithin). SAM-e is thought to benefit cognitive health by supporting the production of such critical brain messengers.* In fact, many people report noticeable positive effects on brain and mood after only taking it for a short time.*

Energy Production

Methylation from SAM-e is also critical for creatine production. Creatine metabolites are important for ADP to ATP recycling and storing energy for immediate needs. Supporting creatine levels may help maximize physical performance, reduce exercise fatigue and improve recovery after exercise.*

Longevity

A healthy young body manufactures all the SAM-e it needs. However, with age, people are less able to produce adequate SAM-e. This may contribute to declining health on many levels. Fortunately, these disturbances are often boosted by SAM-e supplementation.*

In addition, methylation of DNA is an important part of DNA repair. De-methylation of DNA contributes to the aging process. Proper methylation, via substances such as SAM-e, positively influences longevity.*

Healthy Connective Tissue

Research has shown that regular SAM-e supplementation helps support joint health, and is used regularly in Europe to promote joint mobility and comfort.*

Not All SAM-e is Created Equal

SAM-e exists in two forms: (S,S) SAM-e and (R,S) SAM-e. The biologically active form is the (S,S) structure, while the (R,S) structure is inactive. Jarrow Formulas SAM-e is predominantly the active form. It is made naturally by microbiological fermentation and then specially processed, without solvents, to preserve 68-80 percent (S,S) SAM-e, the highest active level available.

SAM-e is a highly reactive molecule and very fragile. It degrades rapidly under high heat or humidity. Improper handling of SAM-e can cause degradation in a matter of hours. Thus, the manufacturing process for Jarrow Formulas SAM-e is done under low temperature and low humidity, and the tablet is enteric coated and blister-packed. Pharmacokinetic studies show that oral supplementation of SAM-e is most effective when enteric-coated by special gastric fluid-resistant polymers, resulting in maximum blood levels.*

Note:

Side effects are rare and appear to be limited to gastrointestinal disturbances. This product complies with the proposed USP Monograph for SAM-e.

Warning:

Individuals using prescribed medications such as antidepressants, including Selective Serotonin Re-Uptake Inhibitors (SSRIs) and MAO Inhibitors should consult a physician before using. Individuals with Parkinson's disease, bi-polar disorder or manic depression should not use SAM-e.

About Jarrow Formulas

Jarrow Formulas' complete line of over 350 nutritional products includes vitamins, minerals, probiotics, standardized herbal concentrates, amino acids, enzymes and enteral nutrition products. Customers can be assured of purity, value and potency when choosing these products.

What's in the Box

Jarrow Formulas SAM-e 200, 200mg, 60 Tablets.

FDA Disclaimer

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Product Details

Size: 60
  • Product Dimensions: 6 x 5 x 4 inches ; 4.8 ounces
  • Shipping Weight: 1.6 ounces (View shipping rates and policies)
  • Shipping: Currently, item can be shipped only within the U.S. and to APO/FPO addresses. For APO/FPO shipments, please check with the manufacturer regarding warranty and support issues.
  • ASIN: B0013OVW0O
  • UPC: 790011200161
  • Item model number: JAR00161
  • Average Customer Review: 4.2 out of 5 stars  See all reviews (104 customer reviews)
  • Amazon Best Sellers Rank: #2,955 in Health & Personal Care (See Top 100 in Health & Personal Care)
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Customer Reviews

We belive it helped relive his pains!
Richard
I decided to try the Jarrow Formulas SAM-e and found it to work just as well as the other brand, and I am saving money.
D. Curran
Since taking the Sam-e he has noticed a great improvement in both, so I keep buying it for him.
Weezy

Most Helpful Customer Reviews

71 of 74 people found the following review helpful By D. J. Smith on April 8, 2011
Size Name: 60 Verified Purchase
I have been on Paxil for years and others b/f but now without insurance I studied this product and tried it after a week or two I feel better than I ever have I don't feel like some say euphoric but also my feeling aren't masked over to where I feel nothing, seems so far that things that would really bother me (while taking the prescribed drugs) I am much more calm about I don't seem to have to take as much as they say you may need to. I feel this is awesome and I am so glad I made this decision. I started with a higher dose and my poor belly was not happy but when I lowered to 200 I really feel great, hope the government doesn't find out about this you probably won't be able to get it anymore LOL
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66 of 69 people found the following review helpful By Emma Antunes on May 28, 2012
Size Name: 60 Verified Purchase
I'd been taking the Webber Naturals brand of SAM-e for a couple of years, as that's what they had at Trader Joe's. I was out, and tried Jarrow brand instead. What a difference! It's as if I was taking nothing before, it had such a dramatic effect (I take it for mood support). What I found out afterwards was that SAM-e reacts with air, so supplements coming in a jar lose their potency quickly. Jarrow packages their SAM-e in blister packs, so they're protected from light and air. I won't buy another brand ever again. I've been consistently pleased with the quality of Jarrow's supplements.
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38 of 39 people found the following review helpful By Donald Toomim on May 18, 2012
Size Name: 60 Verified Purchase
I have been a massage therapist for many years, and since I work for myself, having a positive attitude and outlook are essential for my business viability. I am in my late 50's, and since being a teenager, I have had depression. Some of it seems to be physiological based, although I had significant trauma while growing up, and probably would be diagnosed with Post Traumatic Stress today. I have been using Sam-e for the last 10 years. Most of the time, I use it during the winter, when I combine it with vitamin D-3 for the winter blues. I usually feel a difference in about 2 days, taking 400mg a day in the morning on an empty stomach. My mood goes from feeling sad, depressed, and overwhelmed to positive and looking for what I can do to make a difference in my own and others situations. This year I have continued using into the spring. I combine it with Super-B from Young Living Essential Oils to support its effectiveness.

Recently, my wife has been using 200mg/day to counter inflammation from an autoimmune condition. She is finding it working for her as well.

I have only used Jarrow Formulas brand because of its quality and individual foil packaging. I am aware that Sam-e needs to be refrigerated and packaged properly in order to retain quality and effectiveness. I have also read that the source from Italy is the best. All of which is why I continue to stick with this brand. I have not tried anything else, but to be truthful, any cost advantage is not worth the risk of loosing my functionality and enjoyment of life. Buying from Amazon, especially on the monthly program, has reduced the price so much that it is even cheaper than I can get wholesale as a practitioner.
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31 of 31 people found the following review helpful By rkhbeau2 on January 27, 2012
Size Name: 60 Verified Purchase
I am not sure how I have lived without taking this supplement. My joints no longer ache, my mood is incrediable and I am sleeping straight thru for 8 hours which was unheard of for me. I have only been taking for 5 days and am amazed.
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33 of 36 people found the following review helpful By Sean W on November 5, 2011
Size Name: 60
I had stomach cramps and headache after taking this product two days. Both days I took it on an empty stomach. I liked the mood elevation and general sense of improved attitude and motivation as well as concentration and focus during work. I had a lot of energy for a lot longer. I took some L-carnitine and also some L-Taurine at the same time so perhaps that contributed to the problem with cramping.

Since I am a bit more prone to alkalosis (than acidosis like most of the population) I recognized the sustained stomach cramps as possible alkalosis. I took a few droppers full of phosphoric acid to determine if that was the case. The stomach cramps subsided rapidly thereafter and it only took a couple doses to hold the cramps at bay the rest of the day and also noticed I did not get a headache the second night. I also drank a lot of liquid, primarily water, and noticed that helped me feel optimal. I'll try again tomorrow without the other aminos and try to repeat the problem and determine if strong acid and/or water will counteract it again.

Not finding the stomach cramps and antidote terribly pleasurable I decided to take a day off the SAM-e. What I'm curious about is if anyone else recognized alkalosis as a possible suspect -- and who also tried counteracting it with a potent acid substance (like phosphoric acid) to see if the cramps subsided?

I've also read that a possible contributor to cramping and/or headache are the binders and fillers used by this particular manufacturer -- mallitol apparently being a suspect. I'm thinking anyone prone to alkalosis could be affected by either the amino acid itself or any binders/fillers/coatings that are potential allergens or common intolerant substances.
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46 of 52 people found the following review helpful By Amazon Customer on November 30, 2011
Size Name: 60 Verified Purchase
Jarrow Formulas Sam-e 200mg, 60 Tablets

Since I have quit eating sugar, and began to supplement my diet with several vital products (E, D3, DHA, Fish Oil, Magnesium, CoQ10 and massive dosages of Vitamin C...etc, I have seen a remarkably good change in my blood tests. I then decided to introduce SAM-e to see what benefits it offered. It was a real eyeopener. It made me fairly sleepy,at first, and it has definitely had an affect on my moods. I haven't felt this content in decades! In the beginning, I took 400 mg at nighttime for help with insomnia. Now I split the amount by taking two/200mg tablets ie; one (1) in the AM followed by the nighttime dose (1)200MG, once again. Out of all prescription medication that I have taken for help with depression, this non prescriptive supplement is a pleasant surprise that far exceeds any of my expectations!
I still take the prescribed meds that were prescribed by my physician, but the Sam e just makes such a difference...I am once again an optimist!
Give it a try after talking this over with your physician. It may help you as well.
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Disclaimer: While we work to ensure that product information is correct, on occasion manufacturers may alter their ingredient lists. Actual product packaging and materials may contain more and/or different information than that shown on our Web site. We recommend that you do not solely rely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. For additional information about a product, please contact the manufacturer. Content on this site is for reference purposes and is not intended to substitute for advice given by a physician, pharmacist, or other licensed health-care professional. You should not use this information as self-diagnosis or for treating a health problem or disease. Contact your health-care provider immediately if you suspect that you have a medical problem. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition. Amazon.com assumes no liability for inaccuracies or misstatements about products.