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Sometimes the most important decision to be made is WHO is to make a decision. The further away from the knowledge on which the decision must be based the "decider" is, the less informaiton he has and he is more likely to make an incorrect decision. This explains the folly of most regulation: generally speaking, regulators cannot know what it is they are regulating. Shocking as this might be, but it takes sometimes years - maybe decades - for one person to gain knowledge in some areas of patient treatment, but yet people in the FDA regulate the medical industry anyway with the total impossibility of them ever knowing even a fraction of a percentage of what they are regulating! Of course, this is not unique to the medical field, but applies to all fields - regulators are too far away from the correct KNOWLEDGE to make some types of decisions. This fact of knowledge is inescapable, permanent, and nobody can change it.
Sowell also shows the effects of insurgent movements on social policy and how the movements still exist long after they have outlived their usefulness - beyond their point of diminishing returns. He also shows how the courts really screwed up the judicial system by crusading for social causes instead of interpreting the constitution. In the quest for "solving" problems, many social insurgent groups forget that some problems will never be solved and we just have to live with the necessary trade-offs such situations present to us - some of these groups forget that their "solutions" create other problems that they did not forsee. They forgot that life's problems is weighing trade-offs and some "solutions" replace one problem with another.
The theme, for the most part, is coming to terms with a fact of life: we must decide what trade-offs we want to live with. We cannot perfectly manage all of the information out there, and some of the information is too costly to get for some people. We must balance what we know against the chances of what we do not know. Much is left to chance and that is life.