The Islets of Langerhans (Advances in Experimental Medicine and Biology) [Hardcover]

Md. Shahidul Islam (Editor)

Book Description

Publication Date: May 21, 2010 | ISBN-10: 9048132703 | ISBN-13: 978-9048132706 | Edition: 1st Edition.

This book is a unique and thoughtful blend of critical background information and advances made in a multitude of areas of contemporary islet research. It is an essential reference book, the first of its kind in many years, for professionals as well as for the beginners interested in the study of islet physiology and diabetes. The book is unique in its breadth: it deals with anatomy, histology, ultra-structure, evolution and comparative anatomy, imaging, developmental biology, programming, apoptosis, mitochondrial function, metabolism, cellular signaling, electrophysiology, oscillation of hormone secretion, islets of model animals, immunology, proteomics, regenerative medicine, clinical advances, islet transplantation, and finally islet tumors. Individual chapters contributed by over a hundred experts and enthusiasts, not only provide a balanced view of the recent advances made in the respective fields, but also provide directions and thoughts for future research. Thanks to vivid and colorful illustrations, tables and sketches, the book as a whole, and the individual chapters make reading a pleasant experience. It is a valuable compilation that one would love to possess personally and buy as a present to a colleague.

Editorial Reviews

Review

"It looks very comprehensive and covers all current areas of interest and includes chapters written by world renowned contributors - very nice!" Matthias von Herrath, MD Professor and Director, Center for Type 1 Diabetes Research La Jolla Institute for Allergy and Immunology, La Jolla CA, USA "This book will be welcomed by islet researchers and clinicians interested in the latest developments and theories from which new therapeutics for diabetes can emerge".  Martha Pavlakis, MD Associate Professor of Medicine, Harvard Medical School Medical Director, Kidney and Pancreas Transplantation Beth Israel Deaconess Medical Center Boston, MA, USA "The field of islet biology is assuming increasing importance with the recognition that beta-cell dysfunction is a critical feature of type II diabetes. Improving b-cell function and/or b-cell mass may be the best approach to treating diabetes. Thus, the publication of a book covering so many aspects of this field is timely".  Fred Levine, M.D., Ph.D. Professor, Burnham Institute for Medical Research Director, Sanford Children's Health Research Center La Jolla, CA, USA  "The growing prevalence of both type 1 and type 2 diabetes make islet cell biology a critical concern for a wide range of scientists and health professionals. From anatomy and developmental biology, through islet physiology and biochemistry, to issues of immunology and transplantation, this book is a terrific resource". Jonathan M.W.Slack, Ph.D., F.Med.Sci. Director, Stem Cell Institute, University of Minnesota, Medical School Minneapolis, MN,  USA "This book allows you to enjoy an adventurous and instructive guided tour in the archipelago of the islets of Langerhans. A team of expert and enthusiastic explorers will not only conduct the voyager through almost all niches of this complex and fascinating environment, but also provide him with clues and keys for future exploration of still hidden sites". Prof. Pellegrino Masiello Dept. of Experimental Pathology, University of Pisa, Pisa, Italy "The pancreatic islet is a complex mini-organ whose dysfunction is critical in all forms of diabetes.  This book provides a comprehensive review of the molecular and cellular processes in islet development, gene expression, and physiology and reviews how a better understanding of the pancreatic islet will advance efforts to develop new therapeutic approaches for diabetes.  This book should be quite useful for anyone interested in the pancreatic islet or diabetes". Alvin C. Powers, M.D. Joe C. Davis Chair in Biomedical Science Professor of Medicine, Molecular Physiology and Biophysics Director, Vanderbilt Diabetes Center Vanderbilt University Nashville, TN USA "A very timely book on the Islet of Langerhans that coincides with the realization that pancreatic ß-cell failure is key to all forms of diabetes mellitus and research in the field is exploding. It contains very thoughtful chapters, each by renown experts in their field, and tackles the complexity of this micro-organ in health and disease very comprehensively and thoughtfully. It will likely become a Reference for years to come for basic researchers, clinicians and students interested is diabetes research" Marc Prentki, PhD Professor of Nutrition and Biochemistry Canada Research Chair in Diabetes and Metabolism MDRC Director Montreal, QC Canada  

Review

"It looks very comprehensive and covers all current areas of interest and includes chapters written by world renowned contributors - very nice!" Matthias von Herrath, MD Professor and Director, Center for Type 1 Diabetes Research La Jolla Institute for Allergy and Immunology, La Jolla CA, USA "This book will be welcomed by islet researchers and clinicians interested in the latest developments and theories from which new therapeutics for diabetes can emerge".  Martha Pavlakis, MD Associate Professor of Medicine, Harvard Medical School Medical Director, Kidney and Pancreas Transplantation Beth Israel Deaconess Medical Center Boston, MA, USA "The field of islet biology is assuming increasing importance with the recognition that beta-cell dysfunction is a critical feature of type II diabetes. Improving b-cell function and/or b-cell mass may be the best approach to treating diabetes. Thus, the publication of a book covering so many aspects of this field is timely".  Fred Levine, M.D., Ph.D. Professor, Burnham Institute for Medical Research Director, Sanford Children's Health Research Center La Jolla, CA, USA  "The growing prevalence of both type 1 and type 2 diabetes make islet cell biology a critical concern for a wide range of scientists and health professionals. From anatomy and developmental biology, through islet physiology and biochemistry, to issues of immunology and transplantation, this book is a terrific resource". Jonathan M.W.Slack, Ph.D., F.Med.Sci. Director, Stem Cell Institute, University of Minnesota, Medical School Minneapolis, MN,  USA "This book allows you to enjoy an adventurous and instructive guided tour in the archipelago of the islets of Langerhans. A team of expert and enthusiastic explorers will not only conduct the voyager through almost all niches of this complex and fascinating environment, but also provide him with clues and keys for future exploration of still hidden sites". Prof. Pellegrino Masiello Dept. of Experimental Pathology, University of Pisa, Pisa, Italy "The pancreatic islet is a complex mini-organ whose dysfunction is critical in all forms of diabetes.  This book provides a comprehensive review of the molecular and cellular processes in islet development, gene expression, and physiology and reviews how a better understanding of the pancreatic islet will advance efforts to develop new therapeutic approaches for diabetes.  This book should be quite useful for anyone interested in the pancreatic islet or diabetes". Alvin C. Powers, M.D. Joe C. Davis Chair in Biomedical Science Professor of Medicine, Molecular Physiology and Biophysics Director, Vanderbilt Diabetes Center Vanderbilt University Nashville, TN USA "A very timely book on the Islet of Langerhans that coincides with the realization that pancreatic ß-cell failure is key to all forms of diabetes mellitus and research in the field is exploding. It contains very thoughtful chapters, each by renown experts in their field, and tackles the complexity of this micro-organ in health and disease very comprehensively and thoughtfully. It will likely become a Reference for years to come for basic researchers, clinicians and students interested is diabetes research" Marc Prentki, PhD Professor of Nutrition and Biochemistry Canada Research Chair in Diabetes and Metabolism MDRC Director Montreal, QC Canada  

Product Details

• Hardcover: 820 pages
• Publisher: Springer; 1st Edition. edition (May 21, 2010)
• Language: English
• ISBN-10: 9048132703
• ISBN-13: 978-9048132706
• Product Dimensions: 9.3 x 6.1 x 1.4 inches
• Shipping Weight: 3.3 pounds (View shipping rates and policies)
• Amazon Best Sellers Rank: #2,138,658 in Books (See Top 100 in Books)