Once I found the configuration that worked best for me, I have used this lap desk constantly. The configuration for my computer is...expansion/backup hard drive in the pocket on the left, mouse on the right and computer on a riser/support that I already had to give an extra tilt to the keyboard. The other pocket is used for the mouse cover or mouse when it is not in use.
I agree with the previous comment that the wrist support is a bit uncomfortable for the arm when using a mouse. However, I have learned to use the mouse very close to the rest so that only the wrist and base of the hand is supported, and now it feels fine.
Also, there are two differences between this model and the one without the mouse pads that are not obvious from the pictures ... this model has the wrist rest that makes it easier to access the keyboard and keeps the laptop from slipping toward you, and there are no depressed pockets in the front near the handle opening for misc. pencil, flash drive, etc. working storage.
Overall, this has turned out to be a very comfortable and useful addition to my work.