Authors Dave Nelson and Mike Cox combine the best of the laboratory and best of the classroom, introducing exciting new developments while communicating basic principles of biochemistry.
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'Excellent text book - same detailed text as in previous versions.' -Michael Danson, University of Bath, UK'The new Lehninger is one of the most modern and comprehensive textbooks in biochemistry. - 'Patrick Ziegelmuller, University of Hamburg, Germany
About the Author
DAVID L. NELSON is Professor in the Department of Biochemistry at the University of Wisconsin, Madison. He is also the Academic Program Director for university's Institute for Cross-college Biology Education.University of Wisconsin-Madison, USA. MICHAEL M. COX, University of Wisconsin-Madison, USA
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20 of 20 people found the following review helpful
By J. Yaron
Format:Hardcover|Amazon Verified Purchase
The book is a great resource for learning biochemistry at a fast pace. I'm using it in my Fundamental of Biological Design course, in which we go over a variety of related fields at breakneck speed (3 weeks of biochemistry, 2 weeks of engineering, 1 week of imaging, 3 weeks of genetics, etc..). I had never taken a course in biochemistry during my undergraduate career and this book has proven invaluable in my PhD career.
I would suggest this book to anybody who wants to learn biochemistry at a discussable level, quickly.
I would suggest this book to anybody who wants to learn biochemistry at a discussable level, quickly.
44 of 54 people found the following review helpful
Format:Hardcover
Lehninger
Principles of Biochemistry
David L. Nelson
Michael M. Cox
W. H. Freeman, Hardback, Fifth edition, 2008.
4to. xxix, 1158 pp., G-17, C-8, A-4, AS-35, I-41.
Fifth edition first published in 2008.
Contents [somewhat in brief, necessarily]
About the authors
A Note on the Nature of Science
Preface
1. The Foundations of Biochemistry
1.1. Cellular Foundations
1.2. Chemical Foundations
1.3. Physical Foundations
1.4. Genetic Foundations
1.5. Evolutionary Foundations
I. STRUCTURE AND CATALYSIS
2. Water
2.1. Weak Interactions in Aqueous Solution
2.2. Ionization of Water, Weak Acids, and Weak Bases
2.3. Buffering against pH Changes in Biological systems
2.4. Water as a Reactant
2.5. The Fitness of the Aqueous Environment for Living Organisms
3. Amino Acids, Peptides and Proteins
3.1. Amino Acids
3.2. Peptides and Proteins
3.3. Working with Proteins
3.4. The Structure of Proteins: Primary Structure
4. The Three-Dimensional Structure of Proteins
4.1. Overview of Protein Structure
4.2. Protein Secondary Structure
4.3. Protein Tertiary and Quaternary Structures
4.4. Protein Denaturation and Folding
5. Protein Function
5.1. Reversible Binding of a Protein to a Ligand: Oxygen-Binding Proteins
5.2. Complementary Interactions between Proteins and Ligands: The Immune System and Immunoglobulins
5.3. Protein Interactions Modulated by Chemical Energy: Actin, Myosin, and Molecular Motors
6. Enzymes
6.1. An Introduction to Enzymes
6.2. How Enzymes Work
6.3. Enzyme Kinetics as an Approach to Understanding Mechanism
6.4. Examples of Enzymatic Reactions
6.5. Regulatory Enzymes
7. Garbohydrates and Glycobiology
7.1. Monosaccharides and Disaccharides
7.2. Polysaccharides
7.3. Glycoconjugates: Proteoglycans, Glycoproteins and Glycolipids
7.4. Carbohydrates as Informational Molecules: The Sugar Code
7.5. Working with Carbohydrates
8. Nucleotides and Nucleic Acids
8.1. Some Basics
8.2. Nucleic Acid Structure
8.3. Nucleic Acid Chemistry
8.4. Other Functions of Nucleotides
9. DNA-Based Information Technologies
9.1. DNA Clonning: The Basics
9.2. From Genes to Genomes
9.3. From Genomes to Proteomes
9.4. Genome Alterations and New Products of Biotechnology
10. Lipids
10.1. Storage Lipids
10.2. Structural Lipids in Membranes
10.3. Lipids as Signals, Cofactors, and Pigments
10.4. Working with Lipids
11. Biological Membranes and Transport
11.1. The Composition and Architecture of Membranes
11.2. Membrane Dynamics
11.3. Solute Transport across Membranes
12. Biosignaling
12.1. General Features of Signal Transduction
12.2. G Protein-Coupled Receptors and Second Messengers
12.3. Receptor Tyrosine Kinases
12.4. Receptor Guanylyl Cyclases, cGMP, and Protein Kinase G
12.5. Multivalent Adaptor Proteins and Membrane Raffts
12.6. Gated Ion Channels
12.7. Integrins: Bidirectional Cell Adhesion Receptors
12.8. Regulation of Transcription by Steroid Hormones
12.9. Signaling in Microorganisms and Plants
12.10. Sensory Transduction in Vision, Olfaction, and Gustation
12.11. Regulation of the Cell Cycle by Protein Kinases
12.12. Oncogenes, Tumor Supressor Genes, and Programmed Cell Death
II BIOENERGETICS AND METABOLISM
13. Bioenergetics and Biochemical Reaction Types
13.1. Bioenergetics and Thermodynamics
13.2. Chemical Logic and Common Biochemical Reactions
13.3. Phosphoryl Group Transfer and ATP
13.4. Biological Oxidation-Reduction Reactions
14. Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway
14.1. Glycolysis
14.2. Feeder Pathways for Glycolysis
14.3. Fates of Pyruvate under Anaerobic Conditions: Fermentation
14.4. Glugoneogenesis
14.5. Pentose Phosphate Pathway of Glucose Oxidation
15. Principles of Metabolic Regulation
15.1. Regulation of Metabolic Pathways
15.2. Analysis of Metabolic Control
15.3. Coordinated Regulation of Glycolysis and Gluconeogenesis
15.4. The Metabolism of Glycogen in Animals
15.5. Coordinated Regulation of Glycogen Synthesis and Breakdown
16. The Citric Acid Cycle
16.1. Production of Acetyl-CoA (Activated Acetate)
16.2. Reactions of the Citric Acid Cycle
16.3. Regulation of the Citric Acid Cycle
16.4. The Glyoxylate Cycle
17. Fatty Acid Catabolism
17.1. Digestion, Mobilization, and Transport of Fats
17.2. Oxidation of Fatty Acids
17.3. Ketone Bodies
18. Amino Acid Oxidation and the Production of Urea
18.1. Metabolic Fates of Amino Groups
18.2. Nitrogen Excretion and the Urea Cycle
18.3. Pathways of Amino Acid Degradation
19. Oxidative Phosphorylation and Photophosphorylation
OXIDATIVE PHOSPHORYLATION
19.1. Electron-Transfer Reactions in Mitochondria
19.2. ATP Synthesis
19.3. Regulation of Oxidative Phosphorylation
19.4. Mitochondria in Thermogenesis, Steroid Synthesis, and Apoptosis
19.5. Mitochondrial Genes: Their Origin and the Effects of Mutations
PHOTOSYNTHESIS: HARVESTING LIGHT ENERGY
19.6. General Features of Photophosphorylation
19.7. Light Absorption
19.8. The Central Photochemical Event: Light-Driven Electron Flow
19.9. ATP Synthesis by Photophosphorylation
19.10. The Evolution of Oxygenic Photosynthesis
20. Carbohydrate Biosynthesis in Plants and Bacteria
20.1. Photosynthetic Carbohydrate Synthesis
20.2. Photorespiration and the C4 and CAM Pathways
20.3. Biosynthesis of Starch and Sucrose
20.4. Synthesis of Cell Wall Polysaccharides: Plant Cellulose and Bacterial Peptidoglycan
20.5. Integration of Carbohydrate Metabolism in the Plant Cell
21. Lipid Biosynthesis
21.1. Biosynthesis of Fatty Acids and Eicosanoids
21.2. Biosynthesis of Triacylglycerols
21.3. Biosynthesis of Membrane Phospholipids
21.4. Biosynthesis of Cholesterol, Steroids, and Isoprenoids
22. Biosynthesis of Amino Acids, Nucleotides, and Related Molecules
22.1. Overview of Nitrogen Metabolism
22.2. Biosynthesis of Amino Acids
22.3. Molecules Derived from Amino Acids
22.4. Biosynthesis and Degradation of Nucleotides
23. Hormonal Regulation and Integration of Mammalian Metabolism
23.1. Hormones: Diverse Structures for Diverse Functions
23.2. Tissue-Specific Metabolism: The Division of Labour
23.3. Hormonal Regulation of Fuel Metabolism
23.4. Obesity and the Regulation of Body Mass
23.5. Obesity, the Metabolic Syndrome, and Type 2 Diabetes
III INFORMATIVE PATHWAYS
24. Genes and Chromosomes
24.1. Chromosomal Elements
24.2. DNA Supercoiling
24.3. The Structure of Chromosomes
25. DNA Metabolism
25.1. DNA Replication
25.2. DNA Repair
25.3. DNA Recombination
26. RNA Metabolism
26.1. DNA-Dependent Synthesis of RNA
26.2. RNA Processing
26.3. RNA-Dependent Synthesis of RNA and DNA
27. Protein Metabolism
27.1. The Genetic Code
27.2. Protein Synthesis
27.3. Protein Targeting and Degradation
28. Regulation of Gene Expression
28.1. Principles of Gene Regulation
28.2. Regulation of Gene Expression in Bacteria
28.3. Regulation of Gene Expression in Eukaryotes
Appendix A. Common Abbreviations in the Biochemical Research Literature [A-4]
Appendix B. Abbreviated Solutions to Problems [AS-35]
Glossary [G-17]
Credits [C-8]
Index [I-41]
Boxes [given here in toto only for sake of clarity; first number indicates the actual chapter]
Box 1-1 Molecular Weight, Molecular Mass, and Their Correct Units
Box 1-2 Louis Pasteur and Optical Activity: In Vino, Veritas
Box 1-3 Entropy: The Advantages of Being Disorganized
Box 2-1 Medicine: On Being One's Own Rabbit (Don't Try This at Home! Read more ›
Principles of Biochemistry
David L. Nelson
Michael M. Cox
W. H. Freeman, Hardback, Fifth edition, 2008.
4to. xxix, 1158 pp., G-17, C-8, A-4, AS-35, I-41.
Fifth edition first published in 2008.
Contents [somewhat in brief, necessarily]
About the authors
A Note on the Nature of Science
Preface
1. The Foundations of Biochemistry
1.1. Cellular Foundations
1.2. Chemical Foundations
1.3. Physical Foundations
1.4. Genetic Foundations
1.5. Evolutionary Foundations
I. STRUCTURE AND CATALYSIS
2. Water
2.1. Weak Interactions in Aqueous Solution
2.2. Ionization of Water, Weak Acids, and Weak Bases
2.3. Buffering against pH Changes in Biological systems
2.4. Water as a Reactant
2.5. The Fitness of the Aqueous Environment for Living Organisms
3. Amino Acids, Peptides and Proteins
3.1. Amino Acids
3.2. Peptides and Proteins
3.3. Working with Proteins
3.4. The Structure of Proteins: Primary Structure
4. The Three-Dimensional Structure of Proteins
4.1. Overview of Protein Structure
4.2. Protein Secondary Structure
4.3. Protein Tertiary and Quaternary Structures
4.4. Protein Denaturation and Folding
5. Protein Function
5.1. Reversible Binding of a Protein to a Ligand: Oxygen-Binding Proteins
5.2. Complementary Interactions between Proteins and Ligands: The Immune System and Immunoglobulins
5.3. Protein Interactions Modulated by Chemical Energy: Actin, Myosin, and Molecular Motors
6. Enzymes
6.1. An Introduction to Enzymes
6.2. How Enzymes Work
6.3. Enzyme Kinetics as an Approach to Understanding Mechanism
6.4. Examples of Enzymatic Reactions
6.5. Regulatory Enzymes
7. Garbohydrates and Glycobiology
7.1. Monosaccharides and Disaccharides
7.2. Polysaccharides
7.3. Glycoconjugates: Proteoglycans, Glycoproteins and Glycolipids
7.4. Carbohydrates as Informational Molecules: The Sugar Code
7.5. Working with Carbohydrates
8. Nucleotides and Nucleic Acids
8.1. Some Basics
8.2. Nucleic Acid Structure
8.3. Nucleic Acid Chemistry
8.4. Other Functions of Nucleotides
9. DNA-Based Information Technologies
9.1. DNA Clonning: The Basics
9.2. From Genes to Genomes
9.3. From Genomes to Proteomes
9.4. Genome Alterations and New Products of Biotechnology
10. Lipids
10.1. Storage Lipids
10.2. Structural Lipids in Membranes
10.3. Lipids as Signals, Cofactors, and Pigments
10.4. Working with Lipids
11. Biological Membranes and Transport
11.1. The Composition and Architecture of Membranes
11.2. Membrane Dynamics
11.3. Solute Transport across Membranes
12. Biosignaling
12.1. General Features of Signal Transduction
12.2. G Protein-Coupled Receptors and Second Messengers
12.3. Receptor Tyrosine Kinases
12.4. Receptor Guanylyl Cyclases, cGMP, and Protein Kinase G
12.5. Multivalent Adaptor Proteins and Membrane Raffts
12.6. Gated Ion Channels
12.7. Integrins: Bidirectional Cell Adhesion Receptors
12.8. Regulation of Transcription by Steroid Hormones
12.9. Signaling in Microorganisms and Plants
12.10. Sensory Transduction in Vision, Olfaction, and Gustation
12.11. Regulation of the Cell Cycle by Protein Kinases
12.12. Oncogenes, Tumor Supressor Genes, and Programmed Cell Death
II BIOENERGETICS AND METABOLISM
13. Bioenergetics and Biochemical Reaction Types
13.1. Bioenergetics and Thermodynamics
13.2. Chemical Logic and Common Biochemical Reactions
13.3. Phosphoryl Group Transfer and ATP
13.4. Biological Oxidation-Reduction Reactions
14. Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway
14.1. Glycolysis
14.2. Feeder Pathways for Glycolysis
14.3. Fates of Pyruvate under Anaerobic Conditions: Fermentation
14.4. Glugoneogenesis
14.5. Pentose Phosphate Pathway of Glucose Oxidation
15. Principles of Metabolic Regulation
15.1. Regulation of Metabolic Pathways
15.2. Analysis of Metabolic Control
15.3. Coordinated Regulation of Glycolysis and Gluconeogenesis
15.4. The Metabolism of Glycogen in Animals
15.5. Coordinated Regulation of Glycogen Synthesis and Breakdown
16. The Citric Acid Cycle
16.1. Production of Acetyl-CoA (Activated Acetate)
16.2. Reactions of the Citric Acid Cycle
16.3. Regulation of the Citric Acid Cycle
16.4. The Glyoxylate Cycle
17. Fatty Acid Catabolism
17.1. Digestion, Mobilization, and Transport of Fats
17.2. Oxidation of Fatty Acids
17.3. Ketone Bodies
18. Amino Acid Oxidation and the Production of Urea
18.1. Metabolic Fates of Amino Groups
18.2. Nitrogen Excretion and the Urea Cycle
18.3. Pathways of Amino Acid Degradation
19. Oxidative Phosphorylation and Photophosphorylation
OXIDATIVE PHOSPHORYLATION
19.1. Electron-Transfer Reactions in Mitochondria
19.2. ATP Synthesis
19.3. Regulation of Oxidative Phosphorylation
19.4. Mitochondria in Thermogenesis, Steroid Synthesis, and Apoptosis
19.5. Mitochondrial Genes: Their Origin and the Effects of Mutations
PHOTOSYNTHESIS: HARVESTING LIGHT ENERGY
19.6. General Features of Photophosphorylation
19.7. Light Absorption
19.8. The Central Photochemical Event: Light-Driven Electron Flow
19.9. ATP Synthesis by Photophosphorylation
19.10. The Evolution of Oxygenic Photosynthesis
20. Carbohydrate Biosynthesis in Plants and Bacteria
20.1. Photosynthetic Carbohydrate Synthesis
20.2. Photorespiration and the C4 and CAM Pathways
20.3. Biosynthesis of Starch and Sucrose
20.4. Synthesis of Cell Wall Polysaccharides: Plant Cellulose and Bacterial Peptidoglycan
20.5. Integration of Carbohydrate Metabolism in the Plant Cell
21. Lipid Biosynthesis
21.1. Biosynthesis of Fatty Acids and Eicosanoids
21.2. Biosynthesis of Triacylglycerols
21.3. Biosynthesis of Membrane Phospholipids
21.4. Biosynthesis of Cholesterol, Steroids, and Isoprenoids
22. Biosynthesis of Amino Acids, Nucleotides, and Related Molecules
22.1. Overview of Nitrogen Metabolism
22.2. Biosynthesis of Amino Acids
22.3. Molecules Derived from Amino Acids
22.4. Biosynthesis and Degradation of Nucleotides
23. Hormonal Regulation and Integration of Mammalian Metabolism
23.1. Hormones: Diverse Structures for Diverse Functions
23.2. Tissue-Specific Metabolism: The Division of Labour
23.3. Hormonal Regulation of Fuel Metabolism
23.4. Obesity and the Regulation of Body Mass
23.5. Obesity, the Metabolic Syndrome, and Type 2 Diabetes
III INFORMATIVE PATHWAYS
24. Genes and Chromosomes
24.1. Chromosomal Elements
24.2. DNA Supercoiling
24.3. The Structure of Chromosomes
25. DNA Metabolism
25.1. DNA Replication
25.2. DNA Repair
25.3. DNA Recombination
26. RNA Metabolism
26.1. DNA-Dependent Synthesis of RNA
26.2. RNA Processing
26.3. RNA-Dependent Synthesis of RNA and DNA
27. Protein Metabolism
27.1. The Genetic Code
27.2. Protein Synthesis
27.3. Protein Targeting and Degradation
28. Regulation of Gene Expression
28.1. Principles of Gene Regulation
28.2. Regulation of Gene Expression in Bacteria
28.3. Regulation of Gene Expression in Eukaryotes
Appendix A. Common Abbreviations in the Biochemical Research Literature [A-4]
Appendix B. Abbreviated Solutions to Problems [AS-35]
Glossary [G-17]
Credits [C-8]
Index [I-41]
Boxes [given here in toto only for sake of clarity; first number indicates the actual chapter]
Box 1-1 Molecular Weight, Molecular Mass, and Their Correct Units
Box 1-2 Louis Pasteur and Optical Activity: In Vino, Veritas
Box 1-3 Entropy: The Advantages of Being Disorganized
Box 2-1 Medicine: On Being One's Own Rabbit (Don't Try This at Home! Read more ›
11 of 13 people found the following review helpful
By Amrita Soni
Format:Hardcover|Amazon Verified Purchase
I must admit that I have never browsed through another introductory biochemistry book, and I bought this book specifically because it is the one required for my class. However, I must say that so far, that I find this book quite enjoyable to read. It explains the material clearly and succinctly, such that I understand the material the first time around. The illustrations, like the written material, further do their job of elucidating the concepts being presented. No "uh?" or "duh!" moments so far and I am crossing my fingers that it stays this way. There's nothing worse than taking a complicated class and finding that the textbook does more to confuse and hinder your understanding of the material than further it.
P.S. I only give it 4 stars because, in some cases, the instructor pointed out simplifications made by the author that will be deconstructed in further chapters and shown to actually be false (e.g. Fig 3-13, on the subject of peptide bond formation, shows one of the amino acids having both the N-terminus and C-terminus being neutrally-charged, which would never occur under physiological pH). It would have been nice if the authors labeled these concepts such so that we would clearly understand that it was a simplification. If you have an instructor that really focuses on the nitty-gritty, these are the sorts of things that make a difference in a textbook.
P.S. I only give it 4 stars because, in some cases, the instructor pointed out simplifications made by the author that will be deconstructed in further chapters and shown to actually be false (e.g. Fig 3-13, on the subject of peptide bond formation, shows one of the amino acids having both the N-terminus and C-terminus being neutrally-charged, which would never occur under physiological pH). It would have been nice if the authors labeled these concepts such so that we would clearly understand that it was a simplification. If you have an instructor that really focuses on the nitty-gritty, these are the sorts of things that make a difference in a textbook.
Most Recent Customer Reviews
5.0 out of 5 stars
What is Biochemistry ? Lehninger explain better....
Few words for say that this is THE BOOK of Biochemistry. More than you can expect... A good choice to make !
Published 2 months ago by Alessandro Nutini
5.0 out of 5 stars
Excellent book.
This book contains detailed and excellent material on biochemistry describing cell processes to the core and the chemistry involved with them.
Published 2 months ago by majavsant
2.0 out of 5 stars
Not New
The book I received was not new as I was lead to believe in the description. The cover was scuffed, the corners were bent, and the spine was broken. Read more
Published 2 months ago by Blaine
5.0 out of 5 stars
Hard cover
I bought this book brand new. Very pleased with the edition. I previously bought second hand but the aesthetics of a new book are worth the extra bucks. Read more
Published 3 months ago by Andrej
4.0 out of 5 stars
Biochemistry
Its a nice book. I bought this book to as a requirement for my biochemistry course. It was helpful that i could just remove the individual chapters and take them to class rather... Read more
Published 3 months ago by Tamara Nunez
4.0 out of 5 stars
good book
really complete information, up to date, the sizeof the letter is kind of small but a good resource, every biologist must have it
Published 3 months ago by Marcos A. Amalbert
5.0 out of 5 stars
very useful book
Up to date information and clearly explained concepts. A complete book for biochem I and II. A lot of colorful illustrations and diagrams that summarize key concepts.
Published 3 months ago by tamarindo
4.0 out of 5 stars
Decent text, sometimes VERY difficult to get through
Let's not kid ourselves, Biochemistry is no walk in the park. It sucks. Even if you like chemistry and biology, which I do, it is still a difficult subject when you are moving... Read more
Published 3 months ago by J. Duncan
5.0 out of 5 stars
Good deal
I bought it for my biochemistry class, it cost me only 72 bucks, a good bargain. The book is brand new, I love it. Highly recommend!
Published 4 months ago by Yanmei Hu
4.0 out of 5 stars
Good explanations
Went very thoroughly through the many biochemical processes of the body. For a textbook it did a good job to include diagrams and images to help understand.
Published 5 months ago by miked113
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