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Lehninger Principles of Biochemistry & eBook [Hardcover]

by Albert Lehninger, David L. Nelson, Michael M. Cox
4.3 out of 5 stars  See all reviews (93 customer reviews)

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Book Description

June 15, 2008 1429224169 978-1429224161 Fifth Edition
Lehninger Principles of Biochemistry has been a classroom favourite since its first edition. It is the classic introduction to biochemistry that brings clarity and coherence to an often unwieldy discipline, a textbook on the field's classic core, always made fresh by combining the field's definitive advances with an admirable ability to reach students. In addition to content updates throughout and more emphasis on medical relevance, the fifth edition provides updated pedagogy that supports lecturers in addressing key challenges in teaching the biochemistry course. NEW TO THIS EDITION INCLUSION OF MAJOR ADVANCES IN BIOCHEMISTRY Every chapter has been thoroughly updated to include the most important advances in biochemistry, e.g.: * New discussion of amyloid diseases in the context of protein folding (Chapter 4) * Expanded and updated section on lipid rafts and caveolae to include new material on membrane curvature and the proteins that influence it, and introducing amphitropic proteins and annular lipids (Chapter 11) * New Box 24-2, Epigenetics, Nucleosome Structure, and Histone Variants describing the role of histone modification and nucleosome deposition in the transmission of epigenetic information in heredity BIOCHEMICAL METHODS Understanding of biochemistry and its practical application is increased with new and updated details on the methods used to obtain information, e.g.: * Use of MALDI-MS in determination of oligosaccharide structure (Ch. 7) * Use of tags for protein analysis and purification (Ch. 9) MEDICALLY RELEVANT EXAMPLES An icon is used throughout to denote material of medical interest. Many new examples have been included that relate biochemistry to medicine and to health issues in general. The authors' goal is for students to learn biochemistry and to understand its relevance to life and the planet. SPECIAL THEME: UNDERSTANDING METABOLISM THROUGH OBESITY AND DIABETES Obesity and its medical consequences-cardiovascular disease and diabetes-are fast becoming epidemic in the industrialized world, and this edition includes new material on the biochemical connections between obesity and health throughout the book. This focus on diabetes provides an integrating theme throughout the chapters on metabolism and its control. NEW PROBLEM-SOLVING TOOLS * New in-text Worked Examples help students improve their quantitative problem-solving skills, taking them through some of the most difficult equations. * More than 100 new end-of-chapter problems give students further opportunity to practice what they have learned. * New Data Analysis Problems (one at the end of each chapter) encourage students to synthesize what they have learned and apply their knowledge to the interpretation of data from the literature. FOCUS ON ORGANIC CHEMISTRY FOUNDATIONS This helps students understand biochemistry by drawing on what they learned in their Organic Chemistry module. * New Section 13.2 , Chemical Logic and Common Biochemical Reactions, discusses the common biochemical reaction types that underlie all metabolic reactions. * Chemical logic is reinforced in the discussions of central metabolic pathways. * Mechanism figures feature step-by-step descriptions to help students understand the reaction process. * In the presentation of reaction mechanisms, the book consistently uses a set of conventions introduced and explained in detail with the first enzyme mechanism encountered. * Some of the new problems focus on chemical mechanisms and reinforce mechanistic themes. KEY CONVENTIONS MADE CLEAR Many of the conventions that are so necessary for understanding each biochemical topic and the biochemical literature are broken out of the text and highlighted. These Key Conventions include clear statements of many assumptions and conventions that students are often expected to assimilate without being told (for example, peptide sequences are written from amino- to carboxyterminal end, left to right; nucleotide sequences are written from 5' to 3'end, left to right). This book is supported by a companion website (, which provides a variety of study tools to aid understanding and learning including animated enzyme mechanisms and biochemical techniques, interactive quizzes, molecular structure tutorials and interactive quizzes.

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Editorial Reviews


'Excellent text book - same detailed text as in previous versions.' -Michael Danson, University of Bath, UK'The new Lehninger is one of the most modern and comprehensive textbooks in biochemistry. - 'Patrick Ziegelmuller, University of Hamburg, Germany

About the Author

DAVID L. NELSON is Professor in the Department of Biochemistry at the University of Wisconsin, Madison. He is also the Academic Program Director for university's Institute for Cross-college Biology Education.University of Wisconsin-Madison, USA. MICHAEL M. COX, University of Wisconsin-Madison, USA

Product Details

  • Hardcover: 1263 pages
  • Publisher: W. H. Freeman; Fifth Edition edition (June 15, 2008)
  • Language: English
  • ISBN-10: 1429224169
  • ISBN-13: 978-1429224161
  • Product Dimensions: 11.1 x 8.7 x 1.7 inches
  • Shipping Weight: 6.2 pounds (View shipping rates and policies)
  • Average Customer Review: 4.3 out of 5 stars  See all reviews (93 customer reviews)
  • Amazon Best Sellers Rank: #478,702 in Books (See Top 100 in Books)

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Customer Reviews

Most Helpful Customer Reviews
27 of 28 people found the following review helpful
5.0 out of 5 stars Great resource September 18, 2010
Format:Hardcover|Verified Purchase
The book is a great resource for learning biochemistry at a fast pace. I'm using it in my Fundamental of Biological Design course, in which we go over a variety of related fields at breakneck speed (3 weeks of biochemistry, 2 weeks of engineering, 1 week of imaging, 3 weeks of genetics, etc..). I had never taken a course in biochemistry during my undergraduate career and this book has proven invaluable in my PhD career.

I would suggest this book to anybody who wants to learn biochemistry at a discussable level, quickly.
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51 of 64 people found the following review helpful
Principles of Biochemistry

David L. Nelson
Michael M. Cox

W. H. Freeman, Hardback, Fifth edition, 2008.
4to. xxix, 1158 pp., G-17, C-8, A-4, AS-35, I-41.

Fifth edition first published in 2008.

Contents [somewhat in brief, necessarily]

About the authors
A Note on the Nature of Science

1. The Foundations of Biochemistry
1.1. Cellular Foundations
1.2. Chemical Foundations
1.3. Physical Foundations
1.4. Genetic Foundations
1.5. Evolutionary Foundations


2. Water
2.1. Weak Interactions in Aqueous Solution
2.2. Ionization of Water, Weak Acids, and Weak Bases
2.3. Buffering against pH Changes in Biological systems
2.4. Water as a Reactant
2.5. The Fitness of the Aqueous Environment for Living Organisms

3. Amino Acids, Peptides and Proteins
3.1. Amino Acids
3.2. Peptides and Proteins
3.3. Working with Proteins
3.4. The Structure of Proteins: Primary Structure

4. The Three-Dimensional Structure of Proteins
4.1. Overview of Protein Structure
4.2. Protein Secondary Structure
4.3. Protein Tertiary and Quaternary Structures
4.4. Protein Denaturation and Folding

5. Protein Function
5.1. Reversible Binding of a Protein to a Ligand: Oxygen-Binding Proteins
5.2. Complementary Interactions between Proteins and Ligands: The Immune System and Immunoglobulins
5.3. Protein Interactions Modulated by Chemical Energy: Actin, Myosin, and Molecular Motors

6. Enzymes
6.1. An Introduction to Enzymes
6.2. How Enzymes Work
6.3. Enzyme Kinetics as an Approach to Understanding Mechanism
Read more ›
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4 of 4 people found the following review helpful
4.0 out of 5 stars Lehninger's Principles of Biochemistry December 26, 2013
Format:Hardcover|Verified Purchase
This book is fairly straightforward and easy to follow. I had no difficulty in understanding the topics, and really enjoyed using this book for my biochemistry course. It is almost identical to the 6th edition of Lehninger's, and can be used in place of that text. If you are looking to save some money, purchase this edition. The homework problems in the back of the chapters are also identical.
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3 of 3 people found the following review helpful
By Gabe
This books is easy to understand and uses a ground up approach that reviews gen chem concepts you need for biochemistry as it goes along. I own the third edition and, although I have only gone through the first 9 chapters, I can say that it's the same as the new edition with only a couple illustrations and numbers changed (I haven't compared the end of chapter problems). Good book but save your money and buy an older edition!
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7 of 9 people found the following review helpful
5.0 out of 5 stars Excelent October 30, 2009
Format:Hardcover|Verified Purchase
I have all the editions of Lehninger's, Principles of Biochemistry. I am a Biochemistry Professor and consider it an excelent study book for Medical and all the Health Sciences students.
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2 of 2 people found the following review helpful
3.0 out of 5 stars So So June 20, 2013
Format:Hardcover|Verified Purchase
The format could be improved. The explanations were not well stated and didn't seem to follow a particular order. I was able to get the information out of my molecular textbook, which was more clear and concise. If it is not a required text for the class, don't bother getting this one.
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6 of 8 people found the following review helpful
4.0 out of 5 stars Happy customer. February 28, 2011
By mittzie
Format:Hardcover|Verified Purchase
I used this book in my undergraduate career during a one-semester biochemistry course. The text book has some good figures and flowcharts, great for visual learners such as myself. A little dense in the actual writing of the text, but overall a good intro to biochemistry book.
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1 of 1 people found the following review helpful
5.0 out of 5 stars Very useful January 24, 2014
Format:Hardcover|Verified Purchase
At times the text doesn't go into enough detail on some examples, but the breadth and clarity of the whole makes up for this in every way.
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Most Recent Customer Reviews
4.0 out of 5 stars Good Condition
The book arrived in great condition with no writing or highlighting in it as described. Overall it was a great purchase
Published 1 month ago by Jess
3.0 out of 5 stars Good Enough
Expensive. Not a subject im deeply interested in, but informative non the less. Works well for a biochem class and explains things well enough.
Published 1 month ago by Cody B Harney
5.0 out of 5 stars Cheap Books
You'll be able to experience the world of chemicals like never before! Walk among the amino acids! Frolic amidst the Fatty acids! Read more
Published 2 months ago by Mark
3.0 out of 5 stars Okay book
Er, the book definitely helped me through my Biochemistry class, but other than that, I didn't really use it for much else.
Published 2 months ago by Casey Lin
5.0 out of 5 stars Great book!
Clear concise writing and photos and charts/graphs that make the point quickly. If you are required to have this book use it!
Published 3 months ago by Joseph B Siegle Jr
5.0 out of 5 stars A good textbook.
This is a very thorough book, and it has really good explanations of a lot of the specific steps within pathways. The text can be a little dense at times. Read more
Published 5 months ago by composer_city
1.0 out of 5 stars Look up the word "circumlocution" in the dictionary
If you browse through the rest of the reviews, which are mostly 4/5 stars, the issue of the text's writing style is bought up quite a few times. Read more
Published 5 months ago by James Chico
4.0 out of 5 stars Useful Text
Clear explanations and useful figures to teach the various topics. I am using this for a class that also uses the newer edition and I haven't had a problem with this edition at... Read more
Published 5 months ago by Nicole Beaulieu
5.0 out of 5 stars College required. Easy reading for the kind of topic.
Excellent to have if you are a biochem student.
Good condition, fast delivery, great price, most likely I will sell it after done with class.
Published 5 months ago by acc
4.0 out of 5 stars Good
Slight differences from the 6th. They aren't extreme though, you can have this and be fine in your class. Chapters and sub-chapters contain the same material.
Published 5 months ago by Elliot
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