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Lorenzo's Oil

4.6 out of 5 stars 191 customer reviews

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Editorial Reviews

Oscar nominee Nick Nolte and Academy Award winner Susan Sarandon star in this powerful and unforgettable drama based on a true story.For Augusto and Michaela Odone (Nolte and Sarandon), the news that their five-year-old son, Lorenzo, has a rare terminal disease is sobering, to learn there is no known cure is devastating. Despite the prognosis, the Odones embark on an extraordinary mission of love, consulting and sometimes colliding with the world's top doctors and scientists in the quest to save their son. Their relentless struggle tests their marriage, their beliefs and the boundaries of conventional medicine in this critically acclaimed hit from director George Miller (The Witches of Eastwick).

Special Features

  • Theatrical Trailer

  • Product Details

    • Actors: Nick Nolte, Susan Sarandon, Peter Ustinov, Kathleen Wilhoite, Gerry Bamman
    • Directors: George Miller
    • Writers: George Miller, Nick Enright
    • Producers: George Miller, Doug Mitchell
    • Format: Multiple Formats, Color, NTSC
    • Language: English (Dolby Digital 2.0)
    • Subtitles: French, Spanish
    • Subtitles for the Hearing Impaired: English
    • Region: Region 1 (U.S. and Canada only. Read more about DVD formats.)
    • Aspect Ratio: 1.85:1
    • Number of discs: 1
    • Rated: PG-13 (Parents Strongly Cautioned)
    • Studio: Universal Studios
    • DVD Release Date: June 1, 2010
    • Run Time: 136 minutes
    • Average Customer Review: 4.6 out of 5 stars  See all reviews (191 customer reviews)
    • ASIN: B0001CNRAM
    • Amazon Best Sellers Rank: #10,033 in Movies & TV (See Top 100 in Movies & TV)
    • Learn more about "Lorenzo's Oil" on IMDb

    Customer Reviews

    Top Customer Reviews

    Format: VHS Tape
    This is the true life story of the Odone family, Augusto, Michaela, and Lorenzo, and their battle with Adrenoleukodystrophy (ALD), a disease that attacks the central nervous system by systemically destroying its protective cover, the myelin sheath. It is an extremely rare disease that is transmitted exclusively to males through a gene that is carried by the mother.
    Augusto, an economist, and Michaela, a linguist, were a well educated, well to do, multi-lingual couple with a little son named Lorenzo who was precocious beyond his years. He spoke English and Italian fluently, as well as the language spoken in the community in Africa in which he spent his very early years. When he returned to the United States at about the age of five, his behavior started to change He came overly aggressive and given to emotional outbursts. After much angst on the part of the Odones over what could be wrong, they were finally told that their son suffered from ALD, which was the functional equivalent of having their son being given a death sentence, as there was no cure for this degenerative disease.
    This well educated couple refused to accept the death sentence meted out to their son by the medical establishment. With no medical background, they disregarded conventional medical wisdom and went about trying to find a cure for their son, in a quest so remarkable and so moving, as to inspire absolute awe in the viewer. A more caring or loving set of parents would be hard to find. Lorenzo is surely loved. Together, Augusto and Michaela take on the medical establishment. What they ended up discovering rocked the medical world. To find out just what it was that they specifically did, you will just have to watch the movie.
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    Comment 98 of 99 people found this helpful. Was this review helpful to you? Yes No Sending feedback...
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    Format: DVD
    On 07/20/04, I visited the web site [...] and clicked on ABOUT LORENZO & HIS PARENTS where I obtained the following excerpt:

    "About Lorenzo, his Parents, and Oumouri

    (in answer to the many questions we receive)

    Lorenzo celebrated his 25th birthday on May 29, 2003. He is deprived of most of his functions, but his mind is still there. Lorenzo communicates through blinking his eyelids to say no and wiggling his fingers to say yes. He enjoys music and being read to. Lorenzo will not regain his speech or full mobility until we are successful with remyelination.

    Michaela succumbed to cancer in June 2000. Augusto, who continues the fight for his son, works out of his office at Myelin Project Headquarters located in Dunn Loring, Virginia, just outside of Washington D.C.

    Lorenzo likes to receive mail from his ?friends? and well-wishers. You may write to him c/o The Myelin Project, 2136 Gallows Road, Suite E, Dunn Loring, Virginia 22027."

    I encourage you to visit this web site where you can get an update on The Myelin Project, make a donation to

    The Myelin Project, read a letter from Augusto Odone dated 02/19/04, and see pictures of Lorenzo, his Parents, and Oumouri.
    1 Comment 39 of 40 people found this helpful. Was this review helpful to you? Yes No Sending feedback...
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    Format: VHS Tape
    This is one of those films that sticks with you... there are scenes and overall themes I will NEVER forget. The real life Odone family, portrayed masterfully by Nick Nolte and Susan Surandon, is far beyond what anyone would refer to as inspiring.

    The Odones are a professional power couple. Augusto (Nolte) has adult children from a previous marriage. He and his wife have one child together, young Lorenzo.

    Lorenzo had the benefit of being raised by highly intellectual and caring, multi-lingual parents. Since Augusto Odone is a financial wizard for the World Bank, which provides not only a comfortable, but worldly life for the family now small family. Lorenzo grows up in Africa, speaking English and Italian fluently and being fully conversant in the language spoken by his classmates in Africa.

    When Lorenzo reaches school age, his parents return to the United States and Lorenzo starts school. Suddenly, a child who has grown up fearless and extroverted with others of all ages and cultures is having emotional outbursts in class and getting into fights.

    After it becomes clear that there is a physical reason behind his behavior, not an emotional one, his parents take him to every doctor they can find until they hear that their child has the medical equivalent of a death sentence.

    As a financial expert and a linguist, the medically ignorant Odones are faced with a a problem they don't see a solution for. Their child has a rare disease, so rare, it is financially prohibitive for pharmaceutical companies to invest millions and perhaps even billions on developing a cure. The disease, adrenoleukodystrophy, also known as ALD, is inherited by males from their mothers.
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    2 Comments 39 of 43 people found this helpful. Was this review helpful to you? Yes No Sending feedback...
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    By Gwen on February 20, 2002
    Format: VHS Tape
    Lorenzo's Oil's is a remerkable movie. I had heard about this movie, and the desease the little boy, Lorenzo, is effected with before. When i saw this movie for the first time in 1996, i was overwelmed. The movie is excellent, The acting is wonderful, and overall, i think it was a great idea for the movie. i have seen Loreno's Oils so many times, that i have lost track, and have been so inspired and interested in it, that i have chosen to become a doctor because of it (I'm a highschool sophmore). Also, in my Anatomy class, we have to do a 7 page report on the topic that interests us the most, and of course i chose ALD, Lorenzo's desease, and will also be using clips from the movie as part of my presentation. If this movie can make someone actually WANT to write a 7 page research paper, it must be interesting. i sugest anybody interested in the feild of medicine, or any feild for that matter, watch this movie, just once. after that one time, you'll never be able to stop. I promise.
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