This, like my previous lowepro, is very strong, durable bag. It's a hybrid that serves well if you have carry on camera equipments, a laptop and minor stuffs (like cloths, a book and small personal items), but like every other bag, depends on your own needs, it could be very useful, or totally useless.
pros:
1. well built, I never had quality issue with lowepro and I wouldn't expect one with this bag either.
2. laptop compartment protect your very well, I carry my laptop every day with it, and never worried
3. good for one or two camera system, but limited lens. it's designed for large bodies, like D300, still got room in it, so any SLR should be fine.
4. good extra upper compartment, for books, everything, I can even put a jean, and several t-shirt, and/or limited personal items in it. yet it is just a little shy of A4 size, so keep that in mind when you consider it.
5. plenty of small pockets, ideal for all kinds of digital items.
6. very good design to flip around for quick access to cameras (see below for more), and no, it's not easy for thieves to take advantages of that without let you notice.
7. I once put around 25lbs in it, it you feels very good with very good weight support, you wont easily get tired
cons:
1. the bag, is bulky, though after used it I get used to it, but it is much larger than I think, especially I use it as everyday backpack to work, so in a peak hour subway train, you need to take it off and put on floor.
2. no all weather cover, I really dont understand why they take that feature off, maybe it prevent you from flip over with the cover on, but do u really want to use your camera in that condition? I still believe it's a better than none feature (given that said, the bag will shield off most moisture and light rains, I had it in ligh rain for 5 minutes walk one day and it protect my laptop and camera well, but still with out the cover, I'll always think twice if get heavier.
3. when you get ur camera, 2-3 lens, a laptop, and maybe even a book or so in the bag to make it a 20-30lbs monster, don't expect you can flip it around that easily. check the video, you see they only use the smallest bag in line for that demonstration. but should expect that when you just want to ``carry'' more things with it.
4. it really depends how you will utilize this bag, it might not be able to satisfy your need of capacity, but still, cameras, laptop and ``extra'' things? those are already a lot of things.
I like this bag though it's a little bit big, check out lowepro website for their video about it, you can have a feeling about its size and internal dimensions:
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And if you dont put laptop in it, it's fairly easy to flip around.
Further some people worried about the upper compartment, afraid some weight might push down and damage the cameras, yet I tried, the separate in the middle is very strong, so that's also very good point. It's a hybrid, so there are compromises in design, and definitely not perfect. But overall if you want not just a pure camera bag, and want to put more personal things with you when travel, especially as airplane carry-ons, this bag is very good, and compare to 350 to see the better balance between size and usability.