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The Man Who Invented the Chromosome: A Life of Cyril Darlington
 
 
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The Man Who Invented the Chromosome: A Life of Cyril Darlington [Hardcover]

Oren Solomon Harman (Author)
5.0 out of 5 stars  See all reviews (8 customer reviews)

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Book Description

June 15, 2004

Born by mistake, or connivance, to struggling parents in a small Lancashire cotton town in 1903, an uninspired Darlington inadvertently escaped the obscurity of farming life and rose instead, against all odds, to become within a few short years the world's greatest expert on chromosomes, and one of the most penetrating biological thinkers of the twentieth century. Harman follows Darlington's path from bleak prospects to world fame, showing how, within the most miniscule of worlds, he sought answers to the biggest questions--how species originate, how variation occurs, how Nature, both blind and foreboding, random and insightful, makes her way from deep past to unknown future. But Darlington did not stop there: Chromosomes held within their tiny confines untold, dark truths about man and his culture. This passionate conviction led the once famed Darlington down a path of rebuke, isolation, and finally obscurity.

As The Man Who Invented the Chromosome unfolds Darlington's forgotten tale--the Nazi atrocities, the Cold War, the crackpot Lysenko, the molecular revolution, eugenics, Civil Rights, the welfare state, the changing views of man's place in nature, biological determinism--all were interconnected. Just as Darlington's work provoked him to ask questions about the link between biology and culture, his life raises fundamental questions about the link between science and society.

(20040930)

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About the Author

Oren Solomon Harman is Lady Davis Fellow at Hebrew University of Jerusalem and Lecturer at Bar-Ilan University.

Product Details

  • Hardcover: 342 pages
  • Publisher: Harvard University Press (June 15, 2004)
  • Language: English
  • ISBN-10: 0674013336
  • ISBN-13: 978-0674013339
  • Product Dimensions: 9.6 x 6.2 x 1.1 inches
  • Shipping Weight: 1.4 pounds (View shipping rates and policies)
  • Average Customer Review: 5.0 out of 5 stars  See all reviews (8 customer reviews)
  • Amazon Best Sellers Rank: #2,300,858 in Books (See Top 100 in Books)

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3 of 3 people found the following review helpful:
5.0 out of 5 stars Dawkins' predecessor brought back to life, October 6, 2004
By 
Donald B. Siano (Westfield, NJ USA) - See all my reviews
(REAL NAME)   
This review is from: The Man Who Invented the Chromosome: A Life of Cyril Darlington (Hardcover)
This biography of Cyril Darlington is of a renowned scientist who enjoyed a long career, first as a microscopist exploring the workings of the chromosome, then as a leader in the fight against Lamarckism, Lysenkoism, Marxism, and suppositions on the equality of men. His early career was built primarily on a book, "Recent Advances in Cytology" which brought together a coherent picture of the chromosomes and their role in evolution. Perhaps a key insight, new with him, was that though the chromosomes contained the hereditary information, they could be understood better by seeing how evolution affected them as well.

Darlington was a confirmed materialist, hard headed scientist, but was positively attracted by controversy, and a rather intolerant, arrogant character to boot. He had many enemies, but was a forceful and prominent public voice, who relished his role. This combination makes for a lively biography, and deserves serious consideration by anyone interested in the history of the development of the "modern synthesis" of evolutionary thought. He was a driving force for much of it.

Darlington was during the 1940's to the 1980's a sort of early version of Richard Dawkins, and was opposed for many years by JBS Haldane, who was a sort of early version of Stephen Jay Gould. Many of the controversies, being rooted in deep-seated views of human nature, have hardly changed. There is the Marxist version of a faith in the malleability of man by wishful thinking, opposed by hard lessons drawn from science, evolutionary theory and the observation that man is a creature acting in accordance with hereditary behaviors which have developed differently in different races. Not for Darlington the notion that race is a "social construct" or that IQ is a "reified" useless hypotheis, the same for all races. He was a sociobiologist well before the term was invented.

The first part of the book that deals with Darlingtons cytogenetics is not the easiest read, dealing as it does with a pretty arcane subject in perhaps a little too much detail, even for the informed reader. The old controversies about such things as parsynapsis vs telosynapsis, are enfolded in a vocabulary that will be intimidating to many readers. I wish, though, that he had covered in a little more detail the methods of cytogenetics, the stains used, the sample preparation methods, and so on. Just how hard was it to prepare an informative experiment? A little more about the influence of Darlington's cytological insights on the conventional modern practice of the art would have been welcome too.

No matter--skip on to the major part of the book where Harman covers the course of the debate over the nature of man and the insights brought by an evolutionary perspective. The meat of the book is here.

In his later years, as for all scientists who live a long time, the main developments in his science began to become too much for him--molecular biology, psychometrics, and a bevy of new techniques were to add much that he could appreciate, but could contribute very little. Exploring the big picture, speculating, theorizing and publicizing became his game, and we are better off for it.

Harman has done a splendid job in this biography--he writes clearly, and has a very good understanding of his subject. It is based on exhaustive research and interviews and will be the definitive work for a long time. The many pictures bring the story to life, and make for a lively read. I enjoyed the book a lot and even re-read much of it for a second time!
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2 of 2 people found the following review helpful:
5.0 out of 5 stars A deep book, September 8, 2004
This review is from: The Man Who Invented the Chromosome: A Life of Cyril Darlington (Hardcover)
Harman has produced one of the deepest books about biology and evolution I have encountered in over 30 years of more-than- amateur interest in the field. He has been able to pinpoint the true paradoxes of life: foresight versus randomness, the individual versus the group, the past as against the future. And he has done so with a wonderful pen: understated, deeply intelligent, deeply modest. I believe that while lesser intellects may not comprend its true value, really smart people will recognize it as nothing short of a brilliant book.
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1 of 1 people found the following review helpful:
5.0 out of 5 stars What a brilliant biography!, February 12, 2010
This review is from: The Man Who Invented the Chromosome: A Life of Cyril Darlington (Hardcover)
About forty years ago, my scientific journey as a geneticist started with the study of chromosomes. My very first adviser had studied under Dr. Gates - a colleague of C. D. Darlington (CDD). My adviser always admired CDD, his incisive mind and often mentioned CDD's eccentricity. For some odd reason, I lost interest in cytogenetics and became more interested in population genetics. Now, out of curiosity I picked up this book and read it with great pleasure. It was truly a page-turner. The pettiness and politics among the original pathfinders of genetics (which has since become central to biology), is sprinkled everywhere. Further, his attempts to bring cytology, genetics and evolution together was appreciated by only a few. Unfortunately, it has remained unchanged even to this day! I congratulate the author on his tremendous success. I rediscovered the creative genius of CDD through this book. Additionally, it is great to know that the term "telomere" was coined by CDD (it was wrongly attributed to Muller and McClintock), for which Blackburn and her team won the last year's Nobel. Similarly, the present interest in structural variation could be traced directly to CDD. I was also shocked to find that he thought so clearly about "levels of selection," for which Lewontin gets the credit. In short, it is a sin that genetics and evolution community in general has relegated him to relative obscurity (only accuses him only as a eugenist). The biographer has done not only a justice to CDD's genius, but also rendered a great service to the science of genetics and evolutionary biology.
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Inside This Book (learn more)
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
invented the chromosome, precocity theory, orderly segregation, chromosomal theory, chromosome behavior, cytological work, chiasma formation, genetic crossing, chromosome theory, evolutionary synthesis, experimental breeding, genetics community, cytoplasmic inheritance, genetic systems
Key Phrases - Capitalized Phrases (CAPs): (learn more)
John Innes, Recent Advances, United States, Royal Society, Sir Daniel, Communist Party, Lysenko Affair, Julian Huxley, Bodleian Library, Darlington Papers, New York, Genetical Society, Great Britain, Brenhilda Schafer, Calvin Bridges, Clare Passingham, Edward Murray East, Genetics Society, John Belling, Journal of Genetics, Kate Pinsdorf, Margaret Upcott, Michael Polanyi, Nikolai Vavilov, Sewall Wright
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