Offering a new reading of the Psalms for today, The Manhattan Psalter is a vigorous, personal expression of the 150 Psalms of the Bible. It captures the passionate, intensely human relationship to God of both the original Hebrew author and Sister Juanita. The influence of Sister Juanita's New York background is apparent in her choice of words as she expresses the Psalms and includes modern daily troubles such as crime, cancer, murder of the defenseless, and victimization of widows and orphans. Through each trouble there is the continuous hope in God, that he hears the cries for help, remembering the promises of old, that "God alone can save us." The title The Manhattan Psalter reflects Colon's own background as a New Yorker and Hispanic. The language is contemporary. Begun as a personal project of appropriation of the Psalms as her own prayer, Sister Juanita developed a manuscript for this work which has now come to fruition since her passing.

