This timely reference discusses mass spectrometry in drug metabolism and pharmacokinetic studies. With contributions by professionals from the pharmaceutical industry, this book begins with a review of current mass spectrometry techniques and applications, followed by discussions of various methods for using MS in drug metabolism studies and pharmacokinetics. Highlighting the critical importance of ADME studies for understanding how a drug is absorbed, distributed, metabolized, and excreted by the body, the book s focuses on the use of LC/MS and MALDI-MS. This is a valuable reference for scientists in the pharmaceutical industry, medicine, academia, and even those working in homeland defense.
Mass Spectrometry in Drug Metabolism and Pharmacokinetics
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Editorial Reviews
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“All in all, the book delivers on its promises to introduce and review the current art of mass spectrometry for the related disciplines of drug metabolism and pharmacokinetics. I highly recommend it.” (JACS Book Reviews, June 2009)
“In comparison to other books on mass spectrometry, this one not only provides both the basic and latest knowledge in mass spectrometry, but integrates the theory with applications to drug metabolism and pharmacokinetics.” (Doody's, April 2009)
"Mass Spectrometry in Drug Metabolism and Pharmacokinetics is a valuable and interesting resource for a broad readership, including scientists starting to work in DMPK as well as undergraduate and graduate students getting involved in drug discovery and characterization by means of MS. A wealth of information is provided and all of the contributing authors have done an excellent job in explaining and outlining particular aspects of MS-based tools in DMPK ... the book is highly recommended reading." (Journal of the American Society for Mass Spectrometry, March 2009)
From the Back Cover
Advanced mass spectrometry techniques to support your drug discovery and development research
Inside this book are a host of practical tools and techniques that enable you to fully leverage the capabilities of mass spectrometry in order to get the most out of drug metabolism and pharmacokinetics studies. You'll learn the latest applications for determining how a drug is absorbed, distributed, metabolized, and excreted by the body.
Logically organized, Mass Spectrometry in Drug Metabolism and Pharmacokinetics starts off with an overview of the role of mass spectrometry in drug discovery and development. It then shows you how to perform routine applications before introducing you to sophisticated tools and techniques for solving complex drug metabolism and pharmacokinetics problems. Throughout the book, the main focus is on the use of LC-MS and MALDI-MS.
Each chapter has been written by one or more leading experts who share their own first-hand laboratory experience. You'll gain a wealth of tips for performing successful analyses as well as avoiding common pitfalls. Moreover, the book is packed with features that help you grasp new concepts quickly and put your knowledge into practice, including:
Figures and illustrations to help you understand how to perform specific techniques and applications
Charts and tables that serve as quick summaries and reference guides
Coverage of the latest tested-and-proven techniques
References leading to the primary literature in the field
Carefully edited to ensure thoroughness and a uniform standard of quality, this book is sure to help you advance your own important drug research efforts.
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4.0 out of 5 stars
A good book for MS technologies in PKDM,
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This review is from: Mass Spectrometry in Drug Metabolism and Pharmacokinetics (Hardcover)
This book gives a good introduction of drug metabolism, pharmacokinetics and bioanalytical in pharmaceutical R&D. It also provides information of fundamental LC/MS technologies and typical application examples, such as LC/MS/MS, LC/Q-TOF/MS, LC/ARC/MS, MALD-IMS, in identification of drug metabolites and quantitative analysis. However, this book does not provide detailed information of systematic bioanalytical methods development and validation.
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Inside This Book
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Key Phrases - Statistically Improbable Phrases (SIPs):
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turbo spray, mass defect filtering, isocratic focusing, microdosing strategy, mass defect filters, ion trap theory, mass defect values, quantitative bioanalysis, control sample comparison, hybrid linear ion, metabolite characterization, radioactivity chromatogram, buspirone metabolites, metabolite identification, interference ions, linear ion trap mass spectrometer, unexpected metabolites, solid scintillant, precursor ion scan, different biological matrices, ion suppression effects, metabolite detection, precursor scan, defect plot, accurate mass data Key Phrases - Capitalized Phrases (CAPs): (learn more)
Mass Spectrom, Rapid Commun, Drug Metab, San Antonio, Drug Discov, Life Sci, John Wiley, Boca Raton, Ragu Ramanathan Copyright, New York, Expert Opin, Van Berkel, New Jersey, Pharmacokinetics Plasma, Marcel Dekker, United States, Department of Pharmacokinetics, Methods Phys, Waters Micromass, Cohesive Technologies, San Jose, Bead Beater, The Netherlands, Reference Outcome, Apparent Volume of Distribution Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
turbo spray, mass defect filtering, isocratic focusing, microdosing strategy, mass defect filters, ion trap theory, mass defect values, quantitative bioanalysis, control sample comparison, hybrid linear ion, metabolite characterization, radioactivity chromatogram, buspirone metabolites, metabolite identification, interference ions, linear ion trap mass spectrometer, unexpected metabolites, solid scintillant, precursor ion scan, different biological matrices, ion suppression effects, metabolite detection, precursor scan, defect plot, accurate mass data Key Phrases - Capitalized Phrases (CAPs): (learn more)
Mass Spectrom, Rapid Commun, Drug Metab, San Antonio, Drug Discov, Life Sci, John Wiley, Boca Raton, Ragu Ramanathan Copyright, New York, Expert Opin, Van Berkel, New Jersey, Pharmacokinetics Plasma, Marcel Dekker, United States, Department of Pharmacokinetics, Methods Phys, Waters Micromass, Cohesive Technologies, San Jose, Bead Beater, The Netherlands, Reference Outcome, Apparent Volume of Distribution Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
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