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Matrix Metalloproteinases (Biology of Extracellular Matrix)
 
 
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Matrix Metalloproteinases (Biology of Extracellular Matrix) [Hardcover]

William C. Parks (Editor), Robert P. Mecham (Series Editor)

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Book Description

March 30, 1998 0125450907 978-0125450904 1
The chapters in this book thoroughly cover the structure, regulation, and function of matrix metalloproteinases, and provide information on the latest strategies to inhibit enzyme activity. This work will be an indispensable reference tool for investigators with an interest in extracellular matrix biology, matrix turnover, enzymology and biochemistry of proteinases, developmental biology, pathology, and therapeutic interventions.

Key Features
* Provides state-of-the-art information on a field with broad implications to many areas of biology
* Includes detailed coverage of the structure and regulation of all major matrix metalloproteinases
* Chapters focus on a timely and expanding field
* Topics have direct relevance to understanding human disease pathology of cancer, arthritis, and vascular disease
* Discusses latest strategies used in the development of new therapeutics to inhibit metalloproteinase activity

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Editorial Reviews

Review

"It is an encyclopedia and up-to-date compendium of the minute details of the literature on all characterized MMPs for specialists in this field... would I buy it? Yes."
--CELL
"In all, this book is a very comprehensive coverage of the specialized area of MMPs. The editors and contributors describe not only the current status of research being conducted in this field, but also speculate on the future direction of that research."
--DOODY'S PUBLISHING REVIEWS

From the Back Cover

Matrix metalloproteinases are a family of related enzymes with the combined ability to degrade essentially all components of the extracellular matrix. The chapters in this book thoroughly cover the structure, regulation, and function of matrix metalloproteinases and provide information on the latest strategies to inhibit enzyme activity. This work will be an indispensable reference tool for investigators with an interest in extracellular matrix biology, matrix turnover, enzymology and biochemistry of proteinases, developmental biology, pathology, and therapeutic interventions.
Metalloproteinases function in many biological processes, including:
* Development
* Inflammation
* Wound healing
* Arthritis
* Cancer
* Vascular disease

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Inside This Book (learn more)
First Sentence:
Seldom has a field had such a clearly defined beginning as did the field of matrix metalloproteinases (MMPs). Read the first page
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
matrilysin protein, matrilysin expression, cytogenetic locus, activated matrilysin, synovial cell collagenase, human matrilysin, most matrix metalloproteinase family members, proenzyme domain, collagenase gene expression, collagen substrate specificity, collagenase expression, macrophage elastase, novel human matrix metalloproteinase, human skin fibroblast collagenase, collagenase promoter, mouse embryo implantation, matrixin family, other matrix metalloproteinases, metalloproteinase gene family, migrating keratinocytes, human neutrophil collagenase, collagenase cleavage site, cell surface activation, hemopexin domain, interglobular domain
Key Phrases - Capitalized Phrases (CAPs): (learn more)
Cancer Res, Cell Biol, Arthritis Rheum, Academic Press, Cell Sci, Matrix Metalloproteinases Copyright, Matrix Biol, New York, Nucleic Acids Res, Cell Res, Mat Gel, National Institutes of Health, Protein Chem, Cell Biochem, Cell Physiol, Kidney Int, Protein Sci, Biol Chem, Matrix Suppl, Methods Enzymol, Plenum Press, Cancer Inst, Cancer Lett, Care Med, Cell Genet
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