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Metabolic Engineering: Principles and Methodologies Hardcover – October 16, 1998

ISBN-13: 978-0126662603 ISBN-10: 0126662606 Edition: 1st
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Editorial Reviews

From the Back Cover

Metabolic engineering is an emerging, interdisciplinary field with applications to the production of chemicals, fuels, materials, and pharmaceuticals. The field's novelty lies in the integration of the techniques of molecular biology with the tools of mathematical analysis, to help elucidate metabolic flux control and rational selection of targets for genetic modification. By providing a rigorous description of cell physiology, metabolic engineering also facilitates functional genomics. Its primary objective is to identify specific genetic and environmental manipulations that lead to enhancement of yield and productivity of biotechnological processes, or the overall improvement of cellular properties.
Key elements of the book include pathway integration and consideration of metabolic flux as a fundamental determinant of cell physiology. Metabolic Engineering keeps mathematical complexity to a minimum ,and provides sidebars as additional background on various mathematical operations. Computational tools for pathway analysis are described, and a glossary of biological terms facilitates use of the book by a broad audience of biochemists, molecular biologists, microbiologists, and biochemical/biomedical engineers.

About the Author

Gregory Stephanopoulos is a Professor of Chemical Engineering at MIT. He received his B.S. from the National Technical University of Athens, his M.S. from the University of Florida and his Ph.D. from the University of Minnesota, all in Chemical Engineering. Upon graduation, he joined the Chemical Engineering Faculty of the California Institute of Technology, where he served as Assistant and Associate Professor until 1985. In 1985 he was appointed Professor of Chemical Engineering at MIT where he has been ever since.Stephanopoulos' work has appeared in more than 150 publications and 7 patents. He has been recognized with the Dreyfus Foundation Teacher Scholar Award (1982), Excellence in Teaching Award (1984), and Technical Achievement Award of the AIChE (1984). He has been a Presidential Young Investigator and the Chairman of the Food Pharmaceutical & Bioengineering Division of the American Institute of Chemical Engineers (1992). In 1992 he was a Visiting Professor at the International Research Center for Biotechnology at Osaka University and was elected a Founding Fellow of the American Institute for Medical and Biological Engineering. In 1996 he chaired the first Conference on Metabolic Engineering and gave the inaugural Bayer Lecture on Biochemical Engineering at the University of California at Berkeley. He was honored with the FPBE Division Award at AIChE in 1997.
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Product Details

  • Hardcover: 725 pages
  • Publisher: Academic Press; 1 edition (October 16, 1998)
  • Language: English
  • ISBN-10: 0126662606
  • ISBN-13: 978-0126662603
  • Product Dimensions: 6 x 1.6 x 9 inches
  • Shipping Weight: 2.2 pounds (View shipping rates and policies)
  • Average Customer Review: 5.0 out of 5 stars  See all reviews (1 customer review)
  • Amazon Best Sellers Rank: #1,191,697 in Books (See Top 100 in Books)

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6 of 6 people found the following review helpful By Marshall on August 20, 2006
Format: Hardcover
This book was a very pleasant surprise. It is rigurous yet accessible enough to provide a very clear picture of the metabolic pathway engineering field. Complicated topics like metabolic control and flux analisys (MCA) are very well treated. The examples are usually relevant and well explained, however, some need pen and paper to work up some jumps in the reasoning train. The first chapter is just an introduction whereas the second chapter is a review of cellular metabolism that may result too dense for most people (including myself). Most biologists can probably do away skipping it (althought some examples involving transport where quite interesting). I am glad I didn't put the book away because on chapter 3 things get really exciting. If you are interested in understanding how metabolic pathways are organized and what analytical tools are there available to model them (and eventually "reconfigure") this book for you.

Note: the book is meatn to be undestood and it is nice to see MCA depleted of the hoopla many authors insist on surrounding it with.
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