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Metabonomics in Toxicity Assessment [Hardcover]

Donald G. Robertson (Editor), John Lindon (Editor), Jeremy K. Nicholson (Editor), Elaine Holmes (Editor)

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Book Description

Publication Date: March 1, 2005 | ISBN-10: 0824726650 | ISBN-13: 978-0824726652 | Edition: 1

Filling a gap in the literature, this reference provides comprehensive coverage of all aspects of metabonomics technology including analytical and biologic considerations, as well as sections on chemometrics-devoting entire chapters to critical topics such as biomarkers, metabolite identification, and the use of magic angle spinning for tissue metabonomics. It includes numerous examples illustrating strategies and techniques for the identification of endogenous and xenobiotic metabolites. Providing essential tools for the toxicologist utilizing metabonomic technologies, this guide presents a clear outline of the use of metabonomics in the safety assessment of new chemical entities. OTI #1 1963

Product Details

  • Hardcover: 536 pages
  • Publisher: Informa Healthcare; 1 edition (March 1, 2005)
  • Language: English
  • ISBN-10: 0824726650
  • ISBN-13: 978-0824726652
  • Product Dimensions: 9.4 x 6.2 x 1.2 inches
  • Shipping Weight: 1.8 pounds
  • Amazon Best Sellers Rank: #3,680,237 in Books (See Top 100 in Books)

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Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
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Inside This Book (learn more)
First Sentence:
The availability of the human genome sequence and the sequences of other species gave rise to hope that they would lead to a new set of molecular markers of disease. Read the first page
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
multimammate desert mouse, metabonomic studies, renal osmolytes, metabonomic analysis, metabonomic data, control rat urine, metabonomic technology, responses using probabilistic neural networks, urine spectra, metabonomic approach, using metabonomics, metabonomic study, metabonomics studies, metabonomic investigations, metabonomics technology, urinalysis studies, hydrazine toxicity, orthogonal signal correction, biofluid samples, metabolic space, moderate outliers, resolution proton magnetic resonance spectroscopy, automatic data reduction, platform for studying drug toxicity, urinary metabolite profiles
Key Phrases - Capitalized Phrases (CAPs): (learn more)
Chem Res Toxicol, Magn Reson Med, Pharm Biomed Anal, Anal Chem, Anal Biochem, Arch Toxicol, Comp Biochem Physiol, Mol Pharmacol, Toxicol Appl Pharmacol, New York, Toxicol Sci, Chemometrics Intell Lab Systems, Toxicol Pathol, Clin Chem, Biological Chemistry, Biochim Biophys Acta, Biomedical Sciences Division, Environ Health Perspect, Imperial College of Science, South Kensington, Biochem Pharmacol, Kidney Int, Toxicol Lett, Ann Arbor, Cancer Res
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