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Metal Ions in Biological Systems: Volume 29: Biological Properties of Metal Alkyl Derivatives Hardcover – January 19, 1993

ISBN-13: 978-0824790226 ISBN-10: 0824790227 Edition: 1st

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Editorial Reviews

Review

"A timely contribution to the field of Biological Inorganic Chemistry … .It reveals the vital role played by metal ions in neurodegenerative diseases in general and exposes this rather unfamiliar and specialized area to a wide section of scientists." (Journal of the Indian Chemical Society, February 2008)

"Recommended for most academic libraries and research collections which support research in coordination chemistry, biological inorganic chemistry, and the newer work in protein folding." (E-STREAMS, September 2007)

"This is a worthwhile contribution that should have a broad audience." (Doody's Health Services)

“…concepts are bang up-to-date by breaking research news appearing as reference notes.” (Coordination Chemistry Reviews, Dec 2006) --This text refers to an alternate Hardcover edition.

From the Back Cover

Metal Ions in Life Sciences links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between the chemistry of metals and life processes. The series reflects the interdisciplinary nature of Biological Inorganic Chemistry and coordinates the efforts of scientists in fields like biochemistry, inorganic and coordination chemistry, molecular and structural biology, enzymology, environmental chemistry, physiology, toxicology, biophysics, pharmacy, and medicine. Consequently, the volumes are an essential source for researchers active in these and related fields as well as teachers preparing courses, e.g., in Bioinorganic Chemistry.

Volume 1, offers in 15 stimulating chapters an authoritative view of the fascinating research on Neurodegenerative Diseases and Metal Ions. Written by 41 internationally recognized experts, ithighlights, supported by 130 illustrations, the recent progress made in understanding the role metal ions play in diseases like transmissible spongiform encephalo­pathies (Creutzfeldt-Jakob and related diseases), Alzheimer's, Parkinson's, Huntington's, Wilson's and Menkes' diseases, as well as in familial amyotrophic lateral sclerosis and others. The interplay between metal ions, catecholamines and the formation of reactive oxygen species resulting in oxidative stress is considered, as is the metalloneurochemistry of zinc and the neurotoxicity of aluminum, cadmium, lead, and mercury. The need for novel drugs which manipulate metal-centered neuropathology is emphasized. With more than 2000 references this book is a vital resource for scientists and advanced students. --This text refers to an alternate Hardcover edition.

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