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Methods in Molecular Biophysics: Structure, Dynamics, Function [Hardcover]

Igor N. Serdyuk (Author), Nathan R. Zaccai (Author), Joseph Zaccai (Author)
4.5 out of 5 stars  See all reviews (2 customer reviews)


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Book Description

May 14, 2007 052181524X 978-0521815246 1
Our knowledge of biological macromolecules and their interactions is based on the application of physical methods, ranging from classical thermodynamics to recently developed techniques for the detection and manipulation of single molecules. These methods, which include mass spectrometry, hydrodynamics, microscopy, diffraction and crystallography, electron microscopy, molecular dynamics simulations, and nuclear magnetic resonance, are complementary; each has its specific advantages and limitations. Organised by method, this textbook provides descriptions and examples of applications for the key physical methods in modern biology. It is an invaluable resource for undergraduate and graduate students of molecular biophysics in science and medical schools, as well as research scientists looking for an introduction to techniques beyond their specialty. As appropriate for this interdisciplinary field, the book includes short asides to explain physics aspects to biologists and biology aspects to physicists.
To access the errata for this book, please visit: http://www.cambridge.org/us/catalogue/catalogue.asp?isbn=9780521815246


Editorial Reviews

Review

"A book that teaches the methods well, creates the intellectual framework of our understanding, and can guide the field. Earlier efforts by Cohn and Edsall, Tanford, Edsall and Wyman, and Cantor and Schimmel have served this important purpose in the past, but the advance of time and technology has diluted the force of these classic works in contemporary Biophysics, both in the teaching and the practices of the field. How welcome, then, a clearly written, thoughtful and modern text that will serve well, both in formal courses and as a reference. The authors have built each method from its fundamental premises and principles, have successfully covered an impressive span of topics, and will be rewarded by attention from an audience that hungers for the next defining text in Molecular Biophysics."
D.M. Engelman, Yale University, New Haven, August 2005

"...a valuable contribution to the field. ... There is nothing quite like it at the moment."
Sir Tom Blundell FRS, FMedSci , Professor and Head, Department of Biochemistry, University of Cambridge

"... one of the most comprehensive and highly relevant texts on biophysics that I have encountered in the last 10 years, clearly written and up-to-date. ... a must-have for biophysicists working in all lines of research ..."
Nikolaus Grigorieff, Professor of Biochemistry, Brandeis University

"... a wonderful up-to-date treatise on the many and diverse methods used ... in the fields of molecular biophysics, physical biochemistry, molecular biology, biological physics and the new and emerging field of quantum nanobiology."
Karl J. Jalkanen, Associate Professor of Biophysics, Quantum Protein Centre, Technological University of Denmark

"... a valuable resource for novice and seasoned biophysicists alike."
Dan Minor, California Institute for Quantitative Biomedical Research University of California, San Francisco

"... the book I consult first when faced with an unfamiliar experimental technique. Both classic analytical techniques and the latest single-molecule methods appear in this single comprehensive reference."
Philip Nelson, Department of Physics, University of Pennsylvania, and author of Biological Physics (2004)

"... valuable both for students and research scientists."
Michael G. Rossmann, Hanley Professor of Biological Sciences, Purdue University

"A great achievement ... awaits the student who reads this book ... an excellent reference for the seasoned practitioner of biophysical chemistry."
Milton H Werner, Laboratory of Molecular Biophysics, The Rockefeller University

"This well written, thorough, and elegantly illustrated book provides the connections between molecular biophysics and biology that every aspiring young biologist needs."
Stephen H. White, Department of Physiology and Biophysics, University of California at Irvine

"... I enthusiastically recommend Methods in Molecular Biophysics to anyone who wishes to know more about the techniques by which the properties of biological macromolecules are determined."
David Worcester, Department of Biological Sciences, University of Missouri - Columbia

Book Description

Our knowledge of biological macromolecules is based on the application of a variety of physical methods. This invaluable resource for undergraduate and graduate students of molecular biophysics provides an understanding of these methods, their applications, advantages, and limitations, and is essential to all those working in this interdisciplinary field.

Product Details

  • Hardcover: 1136 pages
  • Publisher: Cambridge University Press; 1 edition (May 14, 2007)
  • Language: English
  • ISBN-10: 052181524X
  • ISBN-13: 978-0521815246
  • Product Dimensions: 9.6 x 7.6 x 2 inches
  • Shipping Weight: 5.7 pounds
  • Average Customer Review: 4.5 out of 5 stars  See all reviews (2 customer reviews)
  • Amazon Best Sellers Rank: #422,052 in Books (See Top 100 in Books)

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6 of 6 people found the following review helpful:
4.0 out of 5 stars Great coverage, needs work though, January 29, 2009
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This review is from: Methods in Molecular Biophysics: Structure, Dynamics, Function (Hardcover)
This is an excellent text in terms of covering the various techniques used in the field. Compared with other similar texts, this one includes mostly everything you'd ever want to know about and goes into good depth on its topics.

That being said, much like other books covering the same subject, this just doesn't feel finished. The book is sometimes brief when it should be explanatory and precise, and its explanations of the science behind the techniques sometimes leave out key logical steps. In its rush to get to complexities in the techniques, it neglects to give concrete examples of the basics. The thermodynamics sub-chapters covering ITC and DSC, for instance, do not spend enough time explaining the basics of how these instruments actually translate their raw data, in the form of graphs, into thermodynamic values. With the relative vacuum of books on these topics, these sorts of things become important - adding a well-labeled diagram and a paragraph or so would not bloat the book too much.

These problems, however, are a common occurrence in textbooks in this field. The competition is not very competitive. In the end, the respectable scope and depth of this book brings it to the front of its rather lackluster pack. Recommended, but I wish there was something better.
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0 of 7 people found the following review helpful:
5.0 out of 5 stars In very good shape~, October 5, 2009
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Zheng Han "h11826" (Tallahassee, FL USA) - See all my reviews
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This review is from: Methods in Molecular Biophysics: Structure, Dynamics, Function (Hardcover)
The book is good and it is like as said, almost new~ I am satisfied for this book~
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Inside This Book (learn more)
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
depolarised fluorescence, mass density increment, mean rotational relaxation time ratio, hermodynamíc stability, primary heat capacity, scattering density contrast, understanding macromolecular structures, correlation time tcor, binding heat capacity, solvent scattering density, radiation scattering particle, fluorescence depolarisation, translational friction, partial specific heat capacity, log raphy, rotational friction coefficient, forward scattered intensity, optical mixing spectroscopy, trehalose glass, kinetic crystallography, neutron crystallography, phospholipid bicelles, arbitrarily shaped particles, conformational coordinate, electric birefringence
Key Phrases - Capitalized Phrases (CAPs): (learn more)
New York, Garcia de la Torre, Hydrodynamics Comment, Academic Press, Mass Spectr, Cif Macromolecule, Hydrodynamics Table, Hydrodynamics Fig, Rev Biophys, Trends Cell Biol, American Chemical Society, Oxford University Press, Macmillan Publishers Ltd, Combining Eqs, Comment Fig, San Diego, San Francisco, Cambridge University Press, Royal Society of Chemistry, Nature Struct, Polar Fourier, Monte Carlo, The Dirac, Prentice Hall, John Wiley
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