"Venous Hypertensive Microangiopathy" reflects recent advances in knowledge in the field of venous ulceration. It covers abnormalities in the microcirculation that have been discovered by capillary microscopy, micro-lymphangilgraphy and fluorescence microscopy. Function of the skin microcirculation has been investigated using laser Doppler fluxmetry and trancutaneous oximetry. More recently, the metabolism of the endothelium has been investigated by immuno-histological methods that have revealed the nature of the inflammatory response to venous hypertension. The author describes these with an interpretation based on his work in the field. The book discusses the controversial role of leucocytes in the pathogenesis of venous ulceration as well as the advanced arguments. An analysis of mechanisms responsible for venous ulceration appears to open new pathways for treatment, and some of the first data from clinical trials are reviewed.
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