I bought this a few years ago...being used to the average two button mouse it took a little while getting used to. However, now I won't use anything else! I wish they came out with a cordless version. It fits my hand so well and the buttons that were a little awkward to use at first are now so easy to use and well placed. I scroll and click with my thumb and move the wheel with my forefinger. The other two programmable buttons to the right of the wheel are clicked with your middle and ring fingers, and the whole device fits my hand like a glove. You barely have to move your fingers to use the buttons, once you get used to the layout and you can even place the trackball horizontally or diaganolly in front of you (which I do) - which is why I don't ever feel "awkward" the way one of the reviewers does. If you place the trackball vertically with the cord facing north, you will ulitmately have a fatigued hand. But after getting used to the layout of this trackball, you don't have to keep it vertical anymore and can place it any way you like. Once placed in a position that is comfortable, it is so natural to operate that using a mouse again is so uncomfortable. If you have the patience to try this out, I highly recommend it. I haven't been able to find a cordless trackball that even comes close to this...pity!
EDIT FROM ORIGINAL POST: It is now September of 2009 and I still have - and love - my Trackball Explorer! I wish I could find another, but currently Amazon has a new one from a seller for $699. That's about $650 over my price range. My Trackball has been dropped a million times and although it's starting to fizz out on me every now and again, it's been with me for 10 years. I don't want to part with it but I think it's been dropped one too many times. All the buttons work and the ball still rolls as smooth as the day I bought it, but the circuits/wires inside the base short out if I bump them in a certain way, so I try to keep it as still as possible now. This little old man still has spunk in him though. I'm considering a Logitech Cordless Optical TrackMan next. It's the closest I can find to my Trackball Explorer. I contacted Microsoft and asked them to reconsider manufacturing these again. They told me (paraphrased here) "Sorry, but no." Well, Logitech, the (track)ball is in your court now, please make one almost exactly like this!