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Mismatch: Why Our World No Longer Fits Our Bodies

7 customer reviews
ISBN-13: 000-0192806831
ISBN-10: 0192806831
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Editorial Reviews


"Mismatch is a salutary reminder that the old genetics, with its rigid separation of nature from nuture, is giving way to a murkier model of inheritance in which the environment, almost as much as DNA, plays a central part as generations succeed one another."-- Science

About the Author

Peter Gluckman is University Distinguished Professor, Professor of Paediatrics and Perinatal Biology, and Director of the Liggins Institute for Medical Research and the National Center for Growth and Development, at the University of Auckland.
Mark Hanson directs the Centre for Developmental Origins of Health and Disease at the University of Southampton, and is an honorary Fellow of the Royal College of Obstetricians and Gynecologists, and Honorary professor at the University of Auckland.

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Product Details

  • Hardcover: 304 pages
  • Publisher: Oxford University Press (October 12, 2006)
  • Language: English
  • ISBN-10: 0192806831
  • ISBN-13: 978-0192806833
  • Product Dimensions: 9.3 x 1.1 x 6.2 inches
  • Shipping Weight: 1.3 pounds (View shipping rates and policies)
  • Average Customer Review: 4.0 out of 5 stars  See all reviews (7 customer reviews)
  • Amazon Best Sellers Rank: #1,573,466 in Books (See Top 100 in Books)

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Customer Reviews

Most Helpful Customer Reviews

16 of 16 people found the following review helpful By Dr Rodney Zentner on December 1, 2006
Format: Hardcover
This is a very interesting and easy to read book. Gluckman and Hanson have managed in less than three hundred pages to explain the consequences of our man-made world not longer being appropriate for the biology we evolved with. They have done so using ideas from evolutionary biology, developmental science and medicine and show an understanding of environmental change and use examples that make this book equally appealing to the technically interested and the absolutely lay reader.

The book is in two parts - the first part is about the science and the second part is about the consequences for human health and disease. Both are filled with examples and there is not much technical language. There are no chapters I found too challenging for a lay reader.

In the second part of the book they use three major illustrations; puberty aging and the menopause and obesity/diabetes. I particularly found their insights into adolescence and puberty refreshing and challenging. The concept that the age of puberty may be returning to an younger age set by evolution, while the age of psychological maturation has moved in the opposite directions changes how one thinks about adolescence and has profound implications - parents, politicians and educators should read chapter 7. Their ideas on the role of foetal development in determining why some individuals are more at risk of diabetes and obesity creates a much more balanced perspective than purely genetic perspectives have led us into. The implications for how to stop the obesity epidemic and the need for different strategies in different populations are most thought provoking and compelling.

But it is not just the specifics of these examples that makes this book so interesting.
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13 of 15 people found the following review helpful By John Matlock on November 30, 2006
Format: Hardcover
The evidence is pretty overwhelming that we developed as humans in the African Savannah. The anthropologists point out how our bodies developed over the millennia to have a lot of characteristics that helped to enable, even guarantee our survival in that environment.

There are numerous books that talk about our special adaptations: no hair ('The Naked Ape' Desmond Morris) so we wouldn't overheat while running, males with eyes optimized to detect movement of game while hunting, females with a thousand times better color sensitivity to detect the ripe fruit from the others.

All this doesn't fit very well with my day of sitting staring at the computer screen, my neighbor's driving a truck, or nearly any of today's ways of earning a living. Yup! There's a mismatch.

The authors do an excellent job of point out our world no longer fit our bodies. This is an insight that we ignore at our peril. They also point out some of the things that humankind might do to change the situation -- but BOY! is their solution going to offend some of the religious fundamentalists. Then again, wouldn't you want your children to be a better match for their society: slimmer, smarter, free from diabetes, cancer, heart disease?
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26 of 34 people found the following review helpful By D. Weise on December 20, 2007
Format: Hardcover Verified Purchase
It is quite a slog to get through this book to basically learn very little new if one already knew anything about genetics and inheritance. I can save you the trouble of reading it by providing the following synopsis.

Gene expression is regulated by many mechanisms. Two of these mechanisms are methylation of the DNA and histone modifications. These two mechanisms are refered to as epigenetic modifications. Studies show they are inheritable. Studies also show that these regulatory mechanisms operate during development. Based on chemical signals provided by the mother, the developing embryo can alter its development to suit the environment it thinks it will be born into (e.g., resource plentiful or resource limited or predator infested or predator free). Whether these developmental choices are effected by epigenetic mechanisms is unclear, and even if they are, it doesn't matter to the authors' arguments that the important part is developmental choices made in the womb.

Fast forward to part II of the book, which discusses "Mismatch". First the authors describe how puberty is occuring earlier and earlier, and that earlier onset started about 100 years ago. Two claims are made. First, that it used to be the case that sexual maturation (the end of puberty) and psychosexual/psycgosocial maturation (the end of adolescence) used to be more in sync. They claim that the further the two get out of sync, the worse it is for kids and society. Second, they make the claim that the time of puberty is simply going back to historical (pleoscene) norms. But these two claims seem to be in conflict, as it would mean that in the far past it was evolutionary useful to have the two be way out sync, which I doubt is the case.
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Format: Hardcover
The book is in two parts. The first deals with matching. With gens and developmental plasticity an organism tries to achieve a better match to its environment. The second part informs us about three main mismatches; the maturational mismatch which is increasing gap between physical maturation and psychosocial maturation, mismatched metabolism resulting in metabolic syndrome and mismatch between our inbuilt repair mechanism and our life course.

The authors explain their thoughts with good examples and concepts. Methylated genes, life-history strategy, metabolic syndrome, developmental plasticity, physical and psychosocial maturation are some of the concepts I derived much benefit.

The notes given at the end of the book are also important and should be read.

The book make me aware of the problems we face and arouse my curiosity to delve further into the relating subject.
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