The way we approach depression scientifically depends on our theoretical framework for depression and its aetiology, and on the tools at our disposal to investigate brain function. Models of depression have evolved, particularly with the introduction of imaging tools such as functional MRI and TMS. This book aims to provide an update on the main themes of depression research. Five of the chapters deal directly with brain imaging methods, either examining brain structure, brain function or functional neurochemistry. A second topic is the renaissance of psychological approaches, both in terms of a neuropsychology of depression and as effective psychotherapy as an important adjunct to pharmacotherapy. The text also explores the change from one-neurotransmitter explanations to delineating complex relationships and interactions in neurochemical models.
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