Customer Reviews

Modern HPLC for Practicing Scientists

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HPLC has become one of the most widely applied chemical analytical techniques in the pharmaceutical industry. Dr Dong's book, Modern HPLC for Practicing Scientists, provides excellent source of information and knowledge for both beginners and highly experienced professionals who utilize this analytical tool. Chapter 1 presents an overview of chromatographic principles while the 2nd chapter deals with fundamental aspects of HPLC and considerations that enhance efficient separation. In chapter 3, Dr. Dong discusses the chromatographic column both from theoretical perspectives and applications. This is very valuable to practicing scientists.

In Chapter 4, the book provides a concise overview of HPLC instrumentation, operating principles as well as recent advances in instrumentation such as Waters Acquity UPLCTM (Chapter 11). A lot of information is provided on practical issues associated with the use of HPLC systems and the pictures and illustrations make their understanding much easier.

Chapter 5 provides a hands-on approach to HPLC analysis including mobile phase preparation and parameter optimization. This is a great chapter for a novel analyst who is often saddled with numerous options on the choice of HPLC parameters. Dr. Dong's attention to details makes it possible even for the novice chromatographer to undertake a full HPLC procedure with little or no supervision

Although Chapters 6 and 7 deal with applications in the pharmaceutical, food and environmental industries, the practicing scientist who this text is best suited for, would benefit more by integrating information from these chapters with the fundamental and practical concepts documented in the earlier chapters.

The inclusion of method development and regulatory issues with respect to HPLC techniques and applications in chapters 8 and 9 is particularly commendable. Industrial R & D scientists who are not only challenged to develop and optimize methods but also work within the constraints of regulatory agencies would find these chapters immensely rewarding. These chapters provide hands-on guidance for laboratory scientists in the pharmaceutical and other regulatory industries.

Chapter 10, dealing with troubleshooting is one of the special attributes of this book. This chapter provides quick fix approach to resolving some of the HPLC's often encountered problems. This chapter is bound to save some cost because more often than not, the HPLC analyst tend to vainly envisage and explore more catastrophic problems ignoring the simple remedies that are succinctly documented in Chapter 10.

Overall, Dr. Dong's book is very well written. Each aspect of the text is clearly and succinctly presented, making it easy to understand. The chapter on maintenance and troubleshooting guide (Chapter 11) should be a great asset. Dr. Dong has managed, in a very basic but meticulous manner, to produce an essential text for both the novice and experienced HPLC practitioner in the pharmaceutical industry.

I'll start by saying I think the book is okay for what it is, and that is a primer, more like 'HPLC lite'. To its credit, it does have a brief overview of most any topic, but this amounts to an ocean of knowledge that is one inch deep. I think users will quickly have to move on to more elaborate texts like High Performance Gradient Elution by Dolan and Snyder, or Trace Quantitative Analysis by Mass Spectrometry by Boyd, Basic and Bethem. For instance, there is only one chapter on ADME and pharmaceutical analysis, and that topic alone could easily fill a book. I appreciate that the author is trying to make a general overview, but the topic is so broad and LC is becoming so specialized that it seems like a quixotic quest to try to condense all of that knowledge down into an introductory text. Might be good for new hires in the lab, but I don't see much use for more experienced scientists.
On the plus side, the Best Practices sections in the operation guide is a great resource for someone new in the field who needs to know the 'rules' of HPLC.

In this concise and very affordable book, Dr. Dong has compiled the most important concepts for anyone interested in the fundamentals of HPLC. He has also taken great care to provide clear illustrations to bring across these concepts, which, like many images, speak a thousand words. In a world inundated with almost too much information, it is very refreshing to have a text in hand that one can read through, understand, and put to use in a short amount of time. As a former research scientist turned Technical Sales Rep, I appreciate that I can put this book to work for me. Every chromatographer, new or experienced, needs to have this book on their shelf, or better yet, on top of the lab bench.

This book is a must for all beginners in HPLC. It is easy to read, well written ,and thorough.The price is very reasonable. I find it a pleasure to read. I bought extra copies for all of my foreign friends who work ot teach HPLC. Dr harold Mc nair
Virginia Tech

This is one of the best books on HPLC I have encountered. Gives an extremely thorough introduction to everything you should know inorder to get started and work confidently with this indispensible technology. Invaluable for the graduate student who wants to go hands on.

This is an excellent book that all liquid chromatographers should have. It covers all aspects of HPLC from theories to instrument to applications. It would benefit all levels of analytical scientists in their day-to-day operations. The book is informative and concise. It also includes an excellent list of references for further interest. I think Michael Dong has done it once again!!! Quite an impressive book! and the price can't be beat!

This is quite a comprehensive treatise on the topic of HPLC. The intended audience is the novice/intermediate and it certainly hit the mark. It is quite apparent that the wealth of recommendations/pointers/guidelines comes from someone very familiar with this topic. This book should be of great help to many aspiring LC chromatographers and should also serve as a valuable reference to those that are already comfortable in this field. - Wilhad M Reuter (PerkinElmer LAS)

I have worked in the biotech industry (and the most well-known biotech company) for more than 10 years and found that this is by far the best HPLC reference book. I haven't seen any other book that contains more insightful information than Dr. Dong's.

This book is worth the price and my time of readig it.

The "Modern HPLC for Practicing Scientists" is a well-written book that covers the fundamental concepts of HPLC applicable to the biotechnology, pharmaceutical and environmental industries. Each chapter was systematically written with illustrative chromatograms, diagrams, graphs and tables. The case studies were very useful and practical which demonstrated the techniques and methodologies in solving the method development challenges. This is a book that every HPLC scientist must own.