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Modern Physical Organic Chemistry [Hardcover]

Eric V. Anslyn , Dennis A. Dougherty
4.8 out of 5 stars  See all reviews (36 customer reviews)

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Book Description

July 15, 2005 1891389319 978-1891389313 illustrated edition
This is the first modern textbook, written in the 21st century, to make explicit the many connections between physical organic chemistry and critical fields such as organometallic chemistry, materials chemistry, bioorganic chemistry, and biochemistry. In the latter part of the 20th century, the field of physical organic chemistry went through dramatic changes, with an increased emphasis on noncovalent interactions and their roles in molecular recognition, supramolecular chemistry, and biology; the development of new materials with novel structural features; and the use of computational methods. Contemporary chemists must be just as familiar with these newer fields as with the more established classical topics. This completely new landmark text is intended to bridge that gap. In addition to covering thoroughly the core areas of physical organic chemistry – structure and mechanism – the book will escort the practitioner of organic chemistry into a field that has been thoroughly updated . The foundations and applicabilities of modern computational methods are also developed. Written by two distinguished researchers in this field, Modern Physical Organic Chemistry can serve as a text for a year-long course targeted to advanced undergraduates or first-year graduate students, as well as for a variety of shorter courses on selected aspects of the field. It will also serve as a landmark new reference text, and as an introduction to many of the more advanced topics of interest to modern researchers. An accompanying Student Solutions Manual will become available.

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Editorial Reviews


"It will certainly inspire." -- Barry Carpenter, Cornell University<br /><br />"This book is the new authoritative physical organic resource that will benefit researchers, students, and teachers alike." -- Timothy Swager, Massachusetts Institute of Technology<br /><br />"This book is the new authoritative physical organic resource that will benefit researchers, students, and teachers alike.” --Timothy Swager, Massachusetts Institute of Technology<br /><br />"This much needed text places physical organic chemistry in its most modern context." -- Timothy M. Swager, MIT<br /><br />I can enthusiastically recommend the text." --Nicholas J. Turro, Columbia University

About the Author

Eric V. Anslyn received his PhD in Chemistry from the California Institute of Technology under the direction of Robert Grubbs. After completing post-doctoral work with Ronald Breslow at Columbia University, he joined the faculty at the University of Texas at Austin, where he became a Full Professor in 1999. He currently holds four patents and is the recipient of numerous awards and honors, including the Presidential Young Investigator, the Alfred P. Sloan Research Fellow, the Searle Scholar, the Dreyfus Teacher-Scholar Award, and the Jean Holloway Award for Excellence in Teaching. He is also the Associate Editor for the Journal of the American Chemical Society and serves on the editorial boards of Supramolecular Chemistry and the Journal of Supramolecular Chemistry. His primary research is in physical organic chemistry and bioorganic chemistry, with specific interests in catalysts for phosphoryl and glycosyl transfers, receptors for carbohydrates and enolates, single and multi-analyte sensors – the development of an electronic tongue, and synthesis of polymeric molecules that exhibit unique abiotic secondary structure. Dennis A. Dougherty received a PhD from Princeton with Kurt Mislow, followed by a year of postdoctoral study with Jerome Berson at Yale. In 1979 he joined the faculty at the California Institute of Technology, where he is now George Grant Hoag Professor of Chemistry. Dougherty's extensive research interests have taken him to many fronts, but he is perhaps best known for development of the cation- interaction, a novel but potent noncovalent binding interaction. More recently, he has addressed molecular neurobiology, developing the in vivo nonsense suppression method for unnatural amino acid incorporation into proteins expressed in living cells. This powerful new tool enables “physical organic chemistry on the brain” - chemical-scale studies of the molecules of memory, thought, and sensory perception and the targets of treatments for Alzheimer's disease, Parkinson's disease, schizophrenia, learning and attention deficits, and drug addiction. His group is now working on extensive experimental and computational studies of the bacterial mechanosensitive channels MscL and MscS, building off the crystal structures of these channels recently reported by the Rees group at Caltech.

Product Details

  • Hardcover: 1104 pages
  • Publisher: University Science; illustrated edition edition (July 15, 2005)
  • Language: English
  • ISBN-10: 1891389319
  • ISBN-13: 978-1891389313
  • Product Dimensions: 8.7 x 11.3 inches
  • Shipping Weight: 6 pounds (View shipping rates and policies)
  • Average Customer Review: 4.8 out of 5 stars  See all reviews (36 customer reviews)
  • Amazon Best Sellers Rank: #160,595 in Books (See Top 100 in Books)

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Customer Reviews

Most Helpful Customer Reviews
26 of 27 people found the following review helpful
5.0 out of 5 stars The long wait is over... September 19, 2006
Phys. Org. Chem. has always been one of my favorite subjects. As I continued to study chemistry during high school, college and grad school, I began to realise that phys org chem represents not so much a separate field as a philosophy and approach; to treat chemical and biological systems from the perspective of structure, conformation, and reactivity which are after all the most fundamental aspects of any such system. I realized that phys org chem is a truly interdisciplinary framework, and any one who has a solid background in it can be a good computational chemist, synthetic organic chemist, and/or bioorganic/biochemist.

Unfortunately, all the classic phys org books until now have been of the 'pure' kind, focusing on mechanism and reactivity, but not discussing the interdisciplinary nature of the topic, especially for biological systems and materials. The wait is over: Modern Physical Organic Chemistry by Dennis Dougherty and Eric Anslyn has completely and satisfactorily reinvented the phys org chem textbook. Now one can look to a wholesome treatment of phys org as a multidisciplinary, fundamental, and exciting approach to both chemistry and biology. The book is worth its price, and covers the gamut of topics, including basic ones like mechanisms and bonding, but also is interspersed with lots of boxes and discussions explaining the applications of basic phys org concepts to host guest systems, proteins and nucleic acids, strained molecules, and materials science. Fantastic reference. It should make you a well-rounded chemist, which is a requirement in today's era of interdisciplinary and collaborative research.
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25 of 26 people found the following review helpful
5.0 out of 5 stars Modern Physical Organic Chemistry October 3, 2005
The book by Anslyn and Daugherty is terrific! I recommend it enthusiastically. It fills a large void in the modern day curriculum, and does so brilliantly. I am grateful to the authors for having done so.

Impressively, the text is sophisticated yet readable, both for those of us who have

studied organic chemistry for many years, and most importantly, for students. I've

spoken with a number of students who echo this sentiment. Furthermore, the text is

thoroughly enjoyable to read and is full of wonderful insights. There are very few

chemistry books I've read where I was anxious to see what was coming next. Anslyn and Dougherty's book is one of them.

It is clear that the authors have taken a great deal of care to express their thoughts

carefully, clearly, and concisely. In addition, they have expertly communicated the

interconnections between physical organic chemistry and all other phases of chemistry, including bioorganic and materials chemistry, and have shown that the tools of the physical organic chemist permeate each of the contemporary sub-disciplines.

The publishers, too, are to be congratulated for taking the time and exercising the

care needed to put together a beautifully formatted rendering of the ideas expressed by the authors. In addition, the binding is strong, well constructed, and gives every indication that it will hold up over many years of repeated use.

"Modern Physical Organic Chemistry" is an important and prized addition to my library. I am certain that it will find its place as one of the most important books in the field that has ever been written. Enjoy!

Dan Little
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10 of 10 people found the following review helpful
5.0 out of 5 stars A fantastic text for reading or for reference December 4, 2009
By spumn
Anslyn and Dougherty's is arguably the single most useful text, on any subject, available to chemists today. Although physical organic chemistry could easily be viewed as a narrow, arcane subject, these authors demonstrate that this is far from the truth. Anslyn and Dougherty have done a marvelous job of presenting a truly unbelievable amount of material in a way that is not only approachable, but also quite detailed and comprehensive. It is often said that the more accessible texts are a mile wide and an inch deep. This text is a mile wide and a mile deep (not entirely surprising, considering it is also arguably the bulkiest text available to chemists today!). If you can think of it, you can probably find it in the index. I would add that this text has a fantastic, 20-page (!) index, something many of the older texts ought to take a lesson from.

The best texts, in any discipline, do not teach anything outside of a practical context. Anslyn and Dougherty present a truly astonishing array of "Connections" boxes, one on almost every page, which explicate real examples from the literature of the section's principles being applied. The reader whose interest is piqued by a particular section will thus find several excellent starting places in the primary literature for further study. As many other reviewers have noted, this is a modern text that stresses interdisciplinary connections. As an example, the Felkin-Anh model of nucleophilic addition to carbonyls is presented as a practical example of the Curtin-Hammett principle. Although this connection may seem obvious to the initiated, it is not the kind of thing that the majority of texts (let alone professors!) emphasize. Nevertheless, discovering these connections is the only way a student will ever begin to think critically about a subject.
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Most Recent Customer Reviews
5.0 out of 5 stars very important and excellent book for any chemist
I highly recommend student to own it . ii is very useful especially for grad student .

it has a universal information
Published 4 months ago by Mohammed Hawsawi
5.0 out of 5 stars A clear recommendation!
I purchased this book since it was one of the few that our professor mentioned in his class. I got it really fast shipped to my destination, the quality of the bound version is... Read more
Published 8 months ago by Adrian Härtsch
5.0 out of 5 stars decent book
A must have for organic graduate students, love it, I take it nearly everyday with me, exercises are a little difficult.
Published 9 months ago by rtliu
5.0 out of 5 stars Phys. Org. Chem. Bible
This book is an extensive description of physical organic phenomena. I recommend this to any graduate student interested in mechanistic organic chemistry. Read more
Published 9 months ago by Brenda Andrade
5.0 out of 5 stars I gave five stars but I don't like it
It is the textbook of my class, so I have to buy that. Since there is not any copies left in the library. However, this book is a little difficult even for a graduate student!
Published 9 months ago by Xiao Jin
5.0 out of 5 stars Required Text
Interesting class. pretty difficult material. but if you want an advanced degree in chemistry, P. Org. is a milestone. Read more
Published 10 months ago by jcd
5.0 out of 5 stars excellent
excellent. The first chapter alone is enough to buy this book. This is a great start for understanding how the various theories of physical organic chemistry fit together.
Published 11 months ago by william carroll
5.0 out of 5 stars Best organic chemistry book I've read.
Arrived on time, in the condition described. It's a great book, hard read at some points but very informative and fairly accessible.
Published 14 months ago by Dan Sheehy
5.0 out of 5 stars Absolutely a MUST for Chemistry Grad students
I first heard of this book from an interview with one of my organic chemistry Professors, who chose this book when asked what one book he would take to a deserted island. Read more
Published 14 months ago by Ajeeth Adhikari
5.0 out of 5 stars Difficult but important
This book reviews most of the concepts required for graduate school by an organic chemist. It has in-depth explanation of what you need to know. Read more
Published 15 months ago by sugam
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