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Molecular Basis of Drug Design and Resistance (Parasitology)
 
 
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Molecular Basis of Drug Design and Resistance (Parasitology) [Paperback]

G. H. Coombs (Author), S. L. Croft (Author)

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Book Description

0521626692 978-0521626699 June 4, 1998 1
This new collection of articles, edited by G. H. Coombs and S. L. Croft include: The current status of antiparasite chemotherapy; A structure-based approach to drug discovery: crystallography and implications for the development of antiparasite drugs; Validating targets for antiparasite chemotherapy; Control of gene expression in viruses and protozoan parasites by antisense oligonucleotides; Parasite proteinases and amino acid metabolism: possibilities for chemotherapeutic exploitation; The mannitol cycle in Eimeria; New approaches to Leishmania chemotherapy: pteridine reductase 1 (PTR1) as a target and modulator of antifolate sensitivity; Target sites of anthelmintics; Quinoline resistance mechanisms in Plasmodium falciparum: the debate goes on; The role of drugs in the control of parasitic nematode infections: must we do without?; Designer drugs: pipe-dreams or realities?

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Book Description

This new collection of articles, edited by G. H. Coombs and S. L. Croft include: The current status of antiparasite chemotherapy; A structure-based approach to drug discovery: crystallography and implications for the development of antiparasite drugs; Validating targets for antiparasite chemotherapy; Control of gene expression in viruses and protozoan parasites by antisense oligonucleotides.

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Inside This Book (learn more)
First Sentence:
Currently is wide variation in the availability and efficacy of drugs for the therapy and prophylaxis of parasitic diseases, both in humans and domestic animals. Read the first page
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
parasite proteinases, antiparasite chemotherapy, mannitol cycle, mannitol levels, pteridine metabolism, chloroquine susceptibility, pteridine reductase, halofantrine resistance, antiparasite drugs, chloroquine accumulation, mannitol biosynthesis, pfmdrl gene, trypanothione reductase, surface metalloproteinase, trypanothione metabolism, purine phosphoribosyltransferases, allopurinol riboside, antiparasite activity, benzimidazole resistance, ivermectin resistance, anthelmintic resistance, mannitol metabolism, parasite biochemistry, purine nucleotide pool, phosphorothioate oligomers
Key Phrases - Capitalized Phrases (CAPs): (learn more)
Journal of Biological Chemistry, Parasitology Today, Biochemical Pharmacology, New York, Nucleic Acids Research, Cambridge University Press, European Journal of Biochemistry, Journal of Infectious Diseases, Journal of Molecular Biology, Journal of Parasitology, United Kingdom, Acta Tropica, Academic Press, Biophysica Acta, Veterinary Parasitology, Journal of Cell Biology, Journal of Medicinal Chemistry, Biochemical Journal, Journal of Protozoology, Angewandte Chemie International Edition, Journal of Antimicrobial Chemotherapy, Keystone Symposium, Annual Review of Biochemistry, Annual Review of Microbiology, British Journal of Pharmacology
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