Customer Reviews

Molecular Biology of The Cell: A Problems Approach

5 star:		(59)
4 star:		(12)
3 star:		(2)
2 star:		(1)
1 star:		(1)

 

 

I'm an amateur biologist, and a professional computer software engineer and product reviewer. A keen interest in the mechanics of genetic expression has drawn me to the beautiful details of cellular mechanics. While this book is everything the other reviewers say (and are qualified to say) it is, let me weigh in on the accompanying CD, which is an area in which I can claim some expertise.

The vast majority of CDs bundled with textbooks are afterthoughts -- either an electronic copy of the text, or some lightly related adjunct materials, usually pulled from the public domain. MBotC is different. The CD is nothing short of breathtaking. A technical tour de force, this CD runs on both Mac and Windows, which is no mean feat. It leverages time-tested technologies such as Netscape, Java, and Quicktime to produce stunningly vivid presentations. It performs well, and is rock-solid stable.

Beyond flawless delivery, the content itself is brilliantly executed. This is largely original content developed for this book, and tied directly into the text chapter by chapter. You get narrated animations that show dozens of cellular processes in a way that catalyzes learning. Videos capture live microscopy showing ATP synthase rotors spinning, microtubules self-assembling, actin crawling, and mitosis mitoting. An image magnifier lets you browse photomicrographs in detail.

Most astounding of all is the seamless incorporation of a molecular viewer, the Chime Java browser plugin, which directly reads and interprets Protein Data Base (PDB) files and displays the models in interactive 3D. The CD includes hundreds of PDB models, including a wonderful reference library of amino acids, nucleotimes, lipids, and sugars.

The CD alone is worth hundreds of dollars, just in the labor expended to assemble material from labs around the world and organize it to fit the chapters of the text. I've used numerous of CDs promising to teach molecular biology, and nothing else comes remotely close to the quality and depth of this volume.

That you can buy the CD -- with a ten-pound book attached -- for [the price] is simply a miracle. It's a no-brainer for anybody remotely interested in cell biology. If you're one of them, you must buy this!

In the past few years quite a few books on molecular biology and genetics have appeared, and all of these have been exceptionally well-written. Most have been updates of previous editions, and if compared with these, the most recent editions have displayed an enthusiasm and excitement that dwarfs their earlier editions. This book, now in its fourth edition, is an example of one of these, and I believe the reason for their increasing quality is the excitement that biologists are now feeling. This is due no doubt to the incredible strides that have been taken in biology in the last few years. Biologists are with complete justification very excited that they understand in greater detail what life is all about, and are looking forward to an even deeper understanding in the decades ahead.

As a non-biologist but one deeply embedded in bioinformatics and certain areas of computational biology, this book served my need to understand in greater detail the underlying biology behind these fields. It is a beautiful book, both from an aesthetic viewpoint and because of its content. The book reads more like a story than a textbook, but the information gain when reading it is considerable, with less entropy than what might be expected from such a deep subject with myriads of terms that must be understood before moving on to others. The author's approach to the book is well-organized, with many accompanying diagrams that illustrate the complicated processes and structures that can occur in the molecular realm. In addition, helpful summaries are put at several places in the book. There are no exercises in this book but there is a workbook that one can purchase separately.

Space prohibits a detailed review of such a large book, but some of the more interesting discussions in the book include: 1. The paragraph on the role of sex in bringing about horizontal genetic exchanges within a species. The thinking is that the genomes of modern eubacteria, archaea, and eucaryotes originated in three different "anthologies" of genes that survived from an ancestral pool in which genes were frequently exchanged. This hypothesis is tempting, argue the authors, since it would explain the fact that eucaryotes are similar to archaea in terms of genetic "information-handling" but more similar to eubacteria from a metabolic standpoint. Horizontal gene transfer has become a very important topic of late, due in part to the uproar on bioengineered foods. 2. The suggestion that eucaryotic cells originated as predators, pointing to the presence of mitochondria as one piece of evidence. 3. The entire chapter on proteins, but especially the discussion on protein folding, allosteric enzymes and allosteric transitions. The discussion on protein folding is qualitative but the authors give interesting insights on this topic. In answering the question as to why only a few of the 20^300 different polypeptide chains will be useful to a living organism, they point to natural selection, and the resulting conformations being stable due to its fine tuning. The extreme sensitivity of protein function to small changes in their structure has recently fueled speculation by religionists as being evidence of "intelligent design", but such speculations, even if true, will not improve the understanding of proteins, and can therefore be safely ignored from a scientific viewpoint. The authors do devote a short paragraph to the discussion of computational methods in the protein folding problem, and also discuss briefly the experimental difficulties in determining the conformations of proteins. They also give some of the mathematical details of steady state enzyme kinetics. 4. The discussion on the need for low mutation rates in order to have life. 5. The section on abnormally folded proteins and their relation to diseases, such as prion diseases. Prions have been a contentious issue of late, due to the issues with "mad cow disease" in Great Britain. 6. The section on the "RNA world" and the origins of life. The authors discuss the need in early cells for molecules to perform reactions that lead to the production of more molecules like themselves. From the standpoint of modern cells, polypeptides, they point out, can serve to be catalysts, but they emphasize that there is no known way in which this type of molecule can copy itself by the specification of another of precisely the same sequence. The talk about one theory, the "pre-RNA" world, as justification for the need for simpler compounds to act as template and catalyst for the synthesis of complementary RNA. 7. The section on heterodimerization and its use in "combinatorial control", the latter being a process in which combinations of different proteins control a cellular process. Although not discussed in this book, the mathematical modeling of combinatorial control and its role in signal transduction systems has taken on more importance in recent years. 8. The section on how genetic switches work and the role of operons thereof. 9. The phenomenon of "transcriptional synergy" in gene activator proteins. Here the transcription rate is higher when several activator proteins are working together than when any of the activators are working alone. 10. The discussion on how circadian clocks can be created using feedback loops in gene regulation. The authors describe an interesting experiment that produced a simple gene clock using techniques from genetic engineering. 11. The section discussing RNA interference, a topic that has taken on enormous importance lately, since using it allows researchers the ability to turn off the expression of individual cellular genes. Indeed pharmaceutical bioinformatics and the role of "in silico" molecular target identification makes use of the ability to "tune" phenotypes by using RNA interference for laboratory validation of the bioinformatic algorithms.

This book is beautifully written and illustrated. It is everything a text book should be, especially for someone like me who wants to learn this on his own.

A typical problem with a book like this is that the first n pages will be very readable and then suddenly there will be an elbow in the learning curve and off the author goes into the esoterica that only the initiated can follow. Not here; the author takes you into very advanced material, but one step at a time, never pandering, never simplifying, but always sure to bring you along. It is like having your head peeled open and a picture of this incredible micro-universe poured in. It is like being programmed by the Matrix.

Further, and of course, the subject matter itself is incredible and awesome (both words used in their traditional sense) one is left with a helpless sense of wonder and enjoyment.

Highly recommended

I've just finished reading this book and i feel this new edition is even better than it's predecessor, which is already not far from perfect. This well-known textbook is a comprehensive overview of what we have known about molecular cell biology, and what's more important is - every material here are treated very clearly and carefully, and this is where this book really shines - I even believe a layman with some elementary knowledge about chemistry and biology could not only read this book from cover to cover but also actually *understand* them.

Both the material and the references are quite up-to-date (not surprising), so don't hesitate to buy if you have the third edition.

I give it five stars because:
1) the authority is doubtless;
2) it's comprehensive, wide in scope;
3) the text is written in plain english, thus won't confuse students in the non-english speaking countries;
4) the figures are *really* excellent, IMHO better than any others that I have seen in other books;
5) the index is nice;

and some minor flaws:
The typesetting of "List of Topics" is somewhat... odd. There are no page numbers associate with the individual topics in that list too. Also I think the reference sections could be better.

So... let it be 4.5 stars.

If you want to try to understand life, then understanding the cell is central, and this text book is apparently the best and most authoritative introduction to the subject at an advanced level. I suppose that most readers would be serious biology students, most of whom intend to do research either in biology or in a closely connected field like medicine. As for myself, I am a mature scientist in a completely different field (experimental physics), and I was motivated to read this book after being both tantalized and frustrated by superficial layman books. At first I was worried I might not have the background to understand the material, but I was delighted to find that all the concepts are explained carefully from the start. It is an awesome book, revealing life to be extremely rich in complexity while at the same time based on simple logical principles. The recent revolutions in this field, many of which are explained in the text, makes me almost wish I had chosen to work in biology instead of physics.

I was preparing for the Subject GRE in Biochemistry and Molecular Biology and in the search for a good book towards the same end, I hit upon a review on this very site of the "The Cell" . Taking a risk I got it. Its worth every dime that I paid for it.Having already read a sizeable portion of its main competitor "Genes", I was in a good condition to conclude that this was by any measure a much better book. Why? well firstly it assumes you have or remember very little background knowledge, so gives you all the details. Advanced users might find this bugging especially the first 200 pages. But as you go on, the book unfolds like a beautiful story raising important fundamental questions frequently(GENES does that too!) which are very stimulating. Secondly The area covered by the book is much wider that many other books of the same caliber. Thirdly its very well illustrated ... and if used along with the CD ... its a piece of art. Fourthly the CD ... its incredible.. and ships with all the needful software. Yes sometimes one does get the feeling that details are short at places, but lets give it to them you cant have evrything of such an immense subject area in one book. All in all, I would recommend it to all my peers. I am a medical graduate and have read a lot of textbooks on many subjects and I must say this one rocks! In its area it is comparable to "Harrison's Textbook of Medicine. Need I say more.P.S.Its really up-to-date.

I'm an undergraduate student in Biology and I was looking for the best book on the subject... after a hard selection of the best ones available, I came up with two great items: Lodish's Cell Molecular Biology and Alberts's Molecular Biology of the Cell.
When I spoke with my older colleagues in college and asked my Cell Biology teachers (they're both career researchers) for their opinion about what should I buy, I always received the same kind of answer: «Well, they're both great references, Lodish's is a very insightful text on the matter, as well as Alberts's. But you know... Alberts's is the real thing, the one to go for: It gives you the most wonderful and comprehensive view of the cellular world!»
So, I decided to buy Alberts's and indeed, it is a terrific book: accurate, up-to-date, really enjoyable to read (for those avid for scientific knowledge), the English is quite accessible, illustrations are excellent, a truly great achievement! From now on, this book will be my «bible»!

I'm a somewhat recent Molecular & Cellular Biology graduate, and the old version of this book was extremely widely used throughout my education. Now a graduate and preparing for the biology GRE, I was immensely overjoyed to see that a new version of my favorite biology book was being released.

It was expensive, but I figured it'd be a new and improved, updated and current version of my favorite book. I figured it'd go into more recent discoveries, recombinant techniques and so on. I figured it'd be chock full of illustrations, diagrams and photos that would make refreshing my memory and learning new things a lot easier. I also figured it'd be the ultimate study guide for college level cellular biology. And, I was right. I have no regrets buying the new version of this book.

If you have the old version and are contemplating taking the plunge and buying the new one, I definitely say go for it. I think I can safely say that you will not be disappointed whatsoever.

If you were forced to have just ONE biology book on your bookshelf, let this be the one. Comprehensive, readable, authoritative, visual...the reasons go on and on. The book comes with a remarkable CD (rolling leukocytes, drosophila development, the list of videos is amazing), but even if you never stick the CD in a drive, the text is well worth the money...
Even if you can't find a great bargain, know that the full price *is* worth it.
Alberts, et al, strikes gold once again.

Yes, 1616 pages and 2 inches thick of madness can be intimidating, but this book is sheer awesomeness in lots of ways. Whether you are self-taught, actually taking the class, or just want a desk reference for cell bio, this is definitely the one to get.

Explanations are clear, have a lot of the extra information (so definitely don't use this for an MCAT bio crash course) that can come in handy at some point, and have lots and lots of images and figures to make it a lot easier. I typically don't look forward to doing reading for class, but my cell bio class definitely has me excited especially because of the way this book is written.

If you've seen all those shining reviews by the people below (and above this), this is just an extra testimonial as to the greatness of this book. I can't stop raving about how this book is the life and soul of any cell bio class. It is a tome that contains pretty much everything you need to know about the whole world of cell bio (at the time the book was published, of course!).