Molecular Biology of the Gene [Hardcover]

James D. Watson (Author)

Book Description

ISBN-10: 0805396098 | ISBN-13: 978-0805396096 | Publication Date: December 1976 | Edition: 3rd

Though completely up-to-date with the latest research advances, the Sixth Edition of James D. Watson’s classic book, Molecular Biology of the Gene retains the distinctive character of earlier editions that has made it the most widely used book in molecular biology. Twenty-two concise chapters, co-authored by six highly respected biologists, provide current, authoritative coverage of an exciting, fast-changing discipline. Mendelian View of the World, Nucleic Acids Convey Genetic Information,The Importance of Weak Chemical Interactions, The Importance of High Energy Bonds, Weak and Strong Bonds Determine Macromolecular Interactions, The Structures of DNA and RNA, Genome Structure, Chromatin and the Nucleosome, The Replication of DNA, The Mutability and Repair of DNA, Homologous Recombination at the Molecular Level, Site-Specific Recombination and Transposition of DNA, Mechanisms of Transcription 13  RNA Splicing, Translation, The Genetic Code, Transcriptional Regulation in Prokaryotes, Transcriptional Regulation in Eukaryotes, Regulatory RNAs, Gene Regulation in Development and Evolution, Genomics and Systems Biology, Techniques of Molecular Biology, Model Organisms.  Intended for those interested in learning more about the basics of Molecular Biology.

--This text refers to an alternate Hardcover edition.

Editorial Reviews

About the Author

James D. Watson was Director of Cold Spring Harbor Laboratory from 1968 to 1993, President from 1994 to 2003, and is now its Chancellor. He spent his undergraduate years at the University of Chicago and received his Ph.D. in 1950 from Indiana University. Between 1950 and 1953, he did postdoctoral research in Copenhagen and Cambridge, England. While at Cambridge, he began the collaboration that resulted in the elucidation of the double-helical structure of DNA in 1953. (For this discovery, Watson, Francis Crick, and Maurice Wilkins were awarded the Nobel Prize in 1962.) Later in 1953, he went to the California Institute of Technology. He moved to Harvard in 1955, where he taught and did research on RNA synthesis and protein synthesis until 1976. He was the first Director of the National Center for Genome Research of the National Institutes of Health from 1989 to 1992. Dr. Watson was sole author of the first, second, and third editions of Molecular Biology of the Gene, and a co-author of the fourth and fifth editions. These were published in 1965, 1970, 1976, 1987, and 2003, respectively. He is also a co-author of two other textbooks:  Molecular Biology of the Cell and Recombinant DNA.

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Tania A. Baker is the Whitehead Professor of Biology at the Massachusetts Institute of Technology and an Investigator of the Howard Hughes Medical Institute. She received a B.S. in biochemistry from the University of Wisconsin, Madison, and a Ph.D. in biochemistry from Stanford University in 1988. Her graduate research was carried out in the laboratory of Professor Arthur Kornberg and focused on mechanisms of initiation of DNA replication. She did postdoctoral research in the laboratory of Dr. Kiyoshi Mizuuchi at the National Institutes of Health, studying the mechanism and regulation of DNA transposition. Her current research explores mechanisms and regulation of genetic recombination, enzyme-catalyzed protein unfolding, and ATP-dependent protein degradation. Professor Baker received the 2001 Eli Lilly Research Award from the American Society of Microbiology and the 2000 MIT School of Science Teaching Prize for Undergraduate Education and was elected as a fellow of the American Academy of Arts and Sciences in 2004. She is co-author (with Arthur Kornberg) of the book DNA Replication, Second Edition.

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Stephen P. Bell is a Professor of Biology at the Massachusetts Institute of Technology and an Investigator of the Howard Hughes Medical Institute. He received B.A. degrees from the Department of Biochemistry, Molecular Biology, and Cell Biology and the Integrated Sciences Program at Northwestern University and a Ph.D. in biochemistry at the University of California, Berkeley in 1991. His graduate research was carried out in the laboratory of Dr. Robert Tjian and focused on eukaryotic transcription. He did postdoctoral research in the laboratory of Dr. Bruce Stillman at Cold Spring Harbor Laboratory, working on the initiation of eukaryotic DNA replication. His current research focuses on the mechanisms controlling the duplication of eukaryotic chromosomes. Professor Bell received the 2001 ASBMB–Schering Plough Scientific Achievement Award, the 1998 Everett Moore Baker Memorial Award for Excellence in Undergraduate Teaching at MIT and the 2006 MIT School of Science Teaching Award.

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Alexander A. F. Gann is Editorial Director of Cold Spring Harbor Laboratory Press, and a faculty member of the Watson School of Biological Sciences at Cold Spring Harbor Laboratory. He received his B.Sc in microbiology from University College London and a Ph.D. in molecular biology from The University of Edinburgh in 1989. His graduate research was carried out in the laboratory of Noreen Murray and focused on DNA recognition by restriction enzymes. He did postdoctoral research in the laboratory of Mark Ptashne at Harvard, working on transcriptional regulation, and that of Jeremy Brockes at the Ludwig Institute of Cancer Research at University College London, where he worked on newt limb regeneration. He was a Lecturer at Lancaster University, U.K., from 1996 to 1999, before moving to Cold Spring Harbor Laboratory. He is co-author (with Mark Ptashne) of the book Genes & Signals (2002).

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Michael Levine is a Professor of Molecular and Cell Biology at the University of California, Berkeley, and is also Co-Director of the Center for Integrative Genomics. He received his B.A. from the Department of Genetics at University of California, Berkeley, and his Ph.D. with Alan Garen in the Department of Molecular Biophysics and Biochemistry from Yale University in 1981. As a postdoctoral fellow with Walter Gehring and Gerry Rubin from 1982-1984, he studied the molecular genetics of Drosophila development.  Professor Levine's research group currently studies the gene networks responsible for the gastrulation of the Drosophila and Ciona (sea squirt) embryos. He holds the F. Williams Chair in Genetics and Development at University of California, Berkeley. He was awarded the Monsanto Prize in Molecular Biology from the National Academy of Sciences in 1996, and was elected to the American Academy of Arts and Sciences in 1996 and the National Academy of Sciences in 1998.

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Richard M. Losick is the Maria Moors Cabot Professor of Biology, a Harvard College Professor, and a Howard Hughes Medical Institute Professor in the Faculty of Arts & Sciences at Harvard University. He received his A.B. in chemistry at Princeton University and his Ph.D. in biochemistry at the Massachusetts Institute of Technology. Upon completion of his graduate work, Professor Losick was named a Junior Fellow of the Harvard Society of Fellows when he began his studies on RNA polymerase and the regulation of gene transcription in bacteria. Professor Losick is a past Chairman of the Departments of Cellular and Developmental Biology and Molecular and Cellular Biology at Harvard University. He received the Camille and Henry Dreyfuss Teacher-Scholar Award, is a member of the National Academy of Sciences, a Fellow of the American Academy of Arts and Sciences, a Fellow of the American Association for the Advancement of Science, a Fellow of the American Academy of Microbiology, a member of the American Philosophical Society, and a former Visiting Scholar of the Phi Beta Kappa Society. Professor Losick is the 2007 winner of the Selman A. Waksman Award of the National Academy of Sciences.

--This text refers to an alternate Hardcover edition.

Product Details

• Hardcover: 739 pages
• Publisher: Benjamin-Cummings Publishing Co.,Subs. of Addison Wesley Longman,US; 3rd edition (December 1976)
• Language: English
• ISBN-10: 0805396098
• ISBN-13: 978-0805396096
• Product Dimensions: 9.8 x 7.3 x 1.5 inches
• Shipping Weight: 3.1 pounds
• Average Customer Review: 4.5 out of 5 stars  See all reviews (16 customer reviews)
• Amazon Best Sellers Rank: #3,153,866 in Books (See Top 100 in Books)

Customer Reviews

Most Helpful Customer Reviews

21 of 22 people found the following review helpful:

5.0 out of 5 stars Molecular Biology of the Gene, October 24, 2002

By 

Joe Zika "Khemprof" (Cincinnati, Ohio) - See all my reviews
(VINE VOICE)   

This review is from: Molecular Biology of the Gene (4th Edition) (Hardcover)

Molecular Biology of the Gene written by James D. Watson is one of the best texts on biology of the molecular level. With ample illustrations this makes a wonderful text for students and those who want to learn more about the primary structures of proteins and the interplay between them.

Molecular genetics is but one part of the whole of biology, the nature of cells and how they divide, but this book makes an attempt to address both in a seemless fashion. Genetic code, the replication of viruses and the control of protein synthesis are all a part of this book.

I found the narrative to be straight forward and very understandable as the author makes the point in a logical and lucid manor. You will need some schooling in the biological sciences as this is not a book for the novice. This text will give the biologist of the future the rigor, the perspective, and the enthusiasm that will be needed to bridge the gap between the single cell and the complexities of higher organisms.

This is an excellent text.

8 of 8 people found the following review helpful:

5.0 out of 5 stars Outstanding source for those interested in molecular biology, April 17, 2008

By 

REIdoc (Rye, NY United States) - See all my reviews

This review is from: Molecular Biology of the Gene (6th Edition) (Hardcover)

I am a clinician scientist and have always had difficulty in relating to pure basic science books. The Molecular Biology of the Gene changed my mind. Outstandingly written chapters with colorful illustrations take you through extremely complex subjects in a breeze. A masterpiece, highly recommended.

6 of 7 people found the following review helpful:

5.0 out of 5 stars GREAT BOOK FOR BIOINFORMATIANS, April 7, 2008

By 

Z. Xie "Z Xie" (Baltimore) - See all my reviews
(REAL NAME)   

This review is from: Molecular Biology of the Gene (6th Edition) (Hardcover)

I am a bioinformatian and always look for a reference molecular biology book which not only covers a range of topics but also is clear enough for a reader with limited knowledge of molecular biology. This books is exactly the one I was looking for. Even more, it provides a nice introduction to some basic molecular biology techniques. Highly recommend to any one who wants to know more about molecular biology from other backgrounds.