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Molecular Biology in Medicinal Chemistry (Methods and Principles in Medicinal Chemistry)
 
 
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Molecular Biology in Medicinal Chemistry (Methods and Principles in Medicinal Chemistry) [Hardcover]

Theodor Dingermann (Editor), Dieter Steinhilber (Editor), Gerd Folkers (Editor), Raimund Mannhold (Series Editor), Hugo Kubinyi (Series Editor)

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Book Description

April 5, 2004 3527304312 978-3527304318 1
This readily comprehensible book explains the identification of molecular targets via cellular assays, reporter genes or transgenic models, as well as surveying recent advances in the synthesis, separation and analysis of drugs. A special section is devoted to molecular genetics methods.
With its examination of these novel methods and generous practical advice, this is essential reading for all pharmaceutical chemists, molecular biologists and medical researchers using molecular methods to study drugs and their action.

Editorial Reviews

Review

"…a book that should definitely be on the shelves of a modern practitioner of medicinal chemistry…" (Journal of Natural Products, February 2005)

"...a welcome addition to the library of anyone seeking to build a multidisciplinary group" (Applied Organometallic Chemistry, June 2004)

"In all, the book touches on some of the trendiest subjects that interface to form the frontier of modern medicinal chemistry." (Kevin G. Rice, Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, Journal of Medicinal Chemistry, Vol. 47, No. 26, 2004)

From the Back Cover

Molecular Biology and Genetic Engineering have made a great impact on the methods and strategies of modern pharmaceutical and medicinal chemistry, transforming virtually every step in the drug development process, from target finding to drug design and ADMET analysis. Even the synthesis and manufacture of pharmaceutically active compounds has benefited from novel approaches based on molecular biology tools.

From the Contents:
  • Cellular Assays in Drug Discovery
  • Transgenic Models
  • Reporter Gene Assay Systems
  • Stereoselective Synthesis with Recombinant Enzymes
  • Nucleic Acid Drugs
  • Enantioseparation of Chiral Drugs
  • NMR-based Drug Discovery
  • Pharmacogenomics and Toxicogenomics

With its broad coverage and up-to-date treatment, this volume is essential reading for all pharmaceutical chemists, molecular biologists and medical researchers using molecular biology tools to study drugs and their action.


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Inside This Book (learn more)
First Sentence:
Cell-based assays allow to study the function of pharmaceutical or disease targets within complex environments and in the overall biological context. Read the first page
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
pure chiral drugs, simultaneous enantioseparation, floxed exon, reporter gene assay system, diastereomeric crystallization, gene assay systems, efficacy insufficient, membrane protein purification, individual drug response, chemical shift perturbations, functional genomics technologies, reporter gene technology, antisense concept, periplasmic expression, bioluminescence resonance energy transfer, enzyme gene polymorphism, reporter gene assays, heterologous protein production, ligand screening, protein synthesis system, drug transporters, chiral selectors, cellular assays, affinity capillary electrophoresis, nucleic acid drugs
Key Phrases - Capitalized Phrases (CAPs): (learn more)
Biol Chem, Proc Natl Acad Sci, Clin Pharmacol Ther, Nat Biotechnol, Mol Pharmacol, Biochem Biophys Res Commun, Hum Genet, New York, Methods Enzymol, Anal Chem, Folkers Copyright, Nucleic Acids Res, Pharmacol Exp Ther, Trends Pharmacol Sci, Anal Biochem, Angew Chem, Biochem Biophys Methods, Biomol Screen, Curr Opin Biotechnol, Mol Biol, Mol Cell Biol, Org Chem, Med Chem, Tetrahedron Lett, Clin Chem
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