One of the challenges faced by every cell as well as by whole organisms is to maintain appropriate concentrations of essential nutrient metals while excluding nonessential toxic metals. Toward that end, all organisms have developed mechanisms for metal homeostasis and detoxification to maintain metal levels within physiological limits. This book brings together current knowledge of the molecular basis of metal homeostasis and detoxification in various eukaryotic model systems, including yeasts, plants, and mammals. It focuses on the cellular systems controlling metal transport, intracellular distribution, and immobilization as well as on systems regulating metal-dependent transcription. In addition to environmental aspects (including phytoremediation), the book treats the pathophysiology of metal deficiency and overload in relation to disease.
Molecular Biology of Metal Homeostasis and Detoxification
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One of the challenges faced by every cell as well as by whole organisms is to maintain appropriate concentrations of essential nutrient metals while excluding nonessential toxic metals. Toward that end, all organisms have developed mechanisms for metal homeostasis and detoxification to maintain metal levels within physiological limits. This book brings together current knowledge of the molecular basis of metal homeostasis and detoxification in various eukaryotic model systems, including yeasts, plants, and mammals. It focuses on the cellular systems controlling metal transport, intracellular distribution, and immobilization as well as on systems regulating metal-dependent transcription. In addition to environmental aspects (including phytoremediation), the book treats the pathophysiology of metal deficiency and overload in relation to disease.
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nonessential toxic metals, sulphur pathway, hepcidin expression, iron regulon, metal homeostasis genes, vacuolar iron, hexose permeases, hemochromatosis type, hepcidin levels, trivalent metalloids, homeostasis networks, dynamic signaling molecule, arsenite transport, metal chaperones, metal transport proteins, synaptic zinc, free zinc concentration, iron uptake genes, nicotianamine synthase, siderophore iron uptake, intracellular iron levels, arsenate tolerance, metal hyperaccumulation, chelator molecules, organic solute transporters Key Phrases - Capitalized Phrases (CAPs): (learn more)
Biol Chem, Proc Natl Acad Sci, Plant Physiol, Mol Biol, Mol Cell Biol, Mol Microbiol, Nat Genet, New Phytol, Pflugers Arch, Biochem Biophys Res Commun, Mol Gen Genet, New York, Biochim Biophys Acta, Hum Mol Genet, Current Genetics, Nucleic Acids Res, Exp Bot, Environ Sci Technol, Physiol Plant, Brain Res, Clin Invest, Hum Genet, Plant Soil, Springer-Verlag Berlin Heidelberg, Biochem Soc Trans New!
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nonessential toxic metals, sulphur pathway, hepcidin expression, iron regulon, metal homeostasis genes, vacuolar iron, hexose permeases, hemochromatosis type, hepcidin levels, trivalent metalloids, homeostasis networks, dynamic signaling molecule, arsenite transport, metal chaperones, metal transport proteins, synaptic zinc, free zinc concentration, iron uptake genes, nicotianamine synthase, siderophore iron uptake, intracellular iron levels, arsenate tolerance, metal hyperaccumulation, chelator molecules, organic solute transporters Key Phrases - Capitalized Phrases (CAPs): (learn more)
Biol Chem, Proc Natl Acad Sci, Plant Physiol, Mol Biol, Mol Cell Biol, Mol Microbiol, Nat Genet, New Phytol, Pflugers Arch, Biochem Biophys Res Commun, Mol Gen Genet, New York, Biochim Biophys Acta, Hum Mol Genet, Current Genetics, Nucleic Acids Res, Exp Bot, Environ Sci Technol, Physiol Plant, Brain Res, Clin Invest, Hum Genet, Plant Soil, Springer-Verlag Berlin Heidelberg, Biochem Soc Trans New!
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Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
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