Molecular Genetic Pathology [Hardcover]

Liang Cheng (Editor), David Zhang (Editor)

Book Description

Publication Date: April 15, 2008 | ISBN-10: 1588299740 | ISBN-13: 978-1588299741 | Edition: 1

Molecular Genetic Pathology presents up-to-date material containing fundamental information relevant to the clinical practice of molecular genetic pathology. Part I examines the clinical areas of molecular biology, genomics, pharmacogenomics and proteomics, while Part II covers the molecular areas of medical genetics, microbiology, hematology, transfusion medicine, oncology and forensic pathology. The volume provides a unique reference for the practicing pathologist and medical geneticist as well as a review book for residents and fellows in training in pathology, medical genetics and molecular genetic pathology.

Editorial Reviews

Review

From the reviews: "A compilation of genetic tests and related information … . This book would be of great interest to molecular genetics fellows, pathology/laboratory medicine residents or fellows, practicing pathologists, and oncologists. It would also be of interest to anyone in the healthcare professions … . I also recommend it to practitioners looking for a comprehensive and concise, state-of-the-art book on clinically useful molecular/genetic tests. It is a great study guide during training and would be a great review book in preparation for specialty board certification exams." (Valerie L. Ng, Doody’s Review Service, July, 2008) "This book provides a comprehensive review of the various molecular genetic tests that are currently being conducted at research and clinical laboratories.  This textbook is robust and would be useful in an advanced genetics course ase part of a clinical-based diagnosic genetics-based graduate program; genetic training postdoctoral program, or molecular genetic pathology post-MD fellowship training program.  In addition, some of the chapters in this book could be incorporated into existing advanced cytogenetic courses or upper-level molecular biology courses. In summary, Molecular Genetic Pathology is a comprehensive review guide that looks at the various theories and methodologies of how molecular genetic testing is being performed." (Reviewed by Peter Hu, Molecular Genetic Technology Program, The University of Texas M.D. Anderson Cancer Center, Houston, Texas) "The book features chapters written by experts in all aspects of molecular pathology … . this is a timely and useful book, principally because of its comprehensiveness. Readers seeking an introduction to molecular diagnostics will probably find it thin on background explanations and overwhelming in detail. … for trainees and laboratory workers in the field who need a quick summary of available techniques and diagnostic markers, it should prove to be a valuable and convenient resource." (Jeffrey Sklar, The New England Journal of Medicine, Vol. 360 (20), May, 2009)

From the Back Cover

Molecular Genetic Pathology presents up-to-date material containing fundamental information relevant to the clinical practice of molecular genetic pathology. Part I examines the clinical areas of molecular biology, genomics, pharmacogenomics and proteomics, while Part II covers the molecular areas of medical genetics, microbiology, hematology, transfusion medicine, oncology and forensic pathology. The volume provides a unique reference for the practicing pathologist and medical geneticist as well as a review book for residents and fellows in training in pathology, medical genetics and molecular genetic pathology.

Product Details

• Hardcover: 788 pages
• Publisher: Humana Press; 1 edition (April 15, 2008)
• Language: English
• ISBN-10: 1588299740
• ISBN-13: 978-1588299741
• Product Dimensions: 11.1 x 8.7 x 1.4 inches
• Shipping Weight: 5.8 pounds (View shipping rates and policies)
• Average Customer Review: 3.0 out of 5 stars  See all reviews (2 customer reviews)
• Amazon Best Sellers Rank: #1,628,053 in Books (See Top 100 in Books)

Customer Reviews

Most Helpful Customer Reviews

6 of 6 people found the following review helpful:

4.0 out of 5 stars studying for MGP boards in outline format, February 17, 2009

By 

Mark Twain - See all my reviews

This review is from: Molecular Genetic Pathology (Hardcover)

Easy to read font, with clear images arranged in sensible format. Uses an outline-based organization of data with information in bullet-point format, thus leading to somewhat to very dense information content. Overall, the text is very similar to the Quick Compendium series offered by the ASCP, although this appears to be tailored for MGP topics.

Pages have a glossy appearance, and images are well-sized and arranged. Has some details on commercial hardware and instrumentation, very basics of Hardy-Weinberg genetics, and less than 3 pages on Bayesian calculations for genetic counseling/risk assessment.

Overall, appears to cover the high-yield areas of MGP boards--but in dense outline format.

Two part arrangement, as taken from the preface: Part 1 - general principles, technology, methodology, microarrays, biomarkers, laser capture, flow cytometry, clinilca genomics, clinical proteomics, pharmacogenomics, FISH, karyotype for oncology, genetic inheritance, and population genetics and counseling; Part 2 - disease based information, including prenatal diagnosis, familial cancer syndromes, molecular testing of solid tumors, molecular path of CNS, molecular virology, bacteriology, mycology, and parisitology, molecular coagulopathies, hemoglobinopathies, diagnostics of lymphoid malignancies, myeloid leukemias, HLA system and transfusion medicine, molecular forensic path (STR analysis), gene therapy, ethical and legal issues in molecular testing, quality assurance and lab inspection

A very good book, considering price and structured information content.

2 of 3 people found the following review helpful:

2.0 out of 5 stars the book is uneven with few good chapters, September 6, 2009

By 

del508 "mol path fellow" (USA) - See all my reviews

This review is from: Molecular Genetic Pathology (Hardcover)

The chapters on hemepath, inherited tumors, and solid tumors are good, as is the chapter on FISH and convential cytogenetics. The book has numerous tables that are helpful for review. The chapter on coagulation and hemoglobinopathies glosses over many topics and lacks suffient detail (ie, no reasonable discussion of VWD). Many of the remaining chapters are too general or vague to be of significant utility or value, for example the chapter on priniciples of cytogenetics is both poorly written and lacks adequate detail, ie, fails to provide list of genes underlying specific chromosomal abberations (eg, Prader-Willi) which is necessary for exam preparation. Unfortunately, the book is loaded with typographical and factual errors. To fix these problems, the authors need to be pay much more attention to details- its indefensible to have so many typo's and statements that are factually incorrect (offhand, TFE3 not TEF3, NF-1 is on 17q11 not 2p22; BRCA1 is on 17q21 not 17p12, and so on and so on). The content of the book needs to be refocused to include more pathology and disease at the expense of entire chapters devoted to laser capture microscopy, TMA, etc. The field needs a good well written review book, eg Essentials of Anatomical Pathology by the same author. Hopefully, the editors will acknowledge the weakness of this text and improve both the quality and scope.