The conceptual basis for molecular mimicry was first defined in the early 1980s when monoclonal antibodies against viruses were also shown to react with non-viral host protein; in this case, measles virus phosphoprotein cross-reacted with host cell cytokeratin, herpes simplex virus type 1 with host-cell vimentin and vaccinia virus with host-cell intermediate filaments. Following this discovery, others emerged, again at the clonal level, that T cell clones against proteins from a variety of infectious agents also reacted with host antigenic determinants. The clonal distinction was imperative for the initial definition of mimicry. At least 30 years prior to our initial description of molecular mimicry involving cross-reactions between numerous microbes, on the polyclonal antibody level, streptococcus was believed to react with renal glomeruli, heart and basal ganglia to account for the glomerulonephritis, heart and valvular disease and chorea, respectively. However, subsequent research showed that the nephritis was caused by immune complex deposits and the tissue damage they produced. Later, in 1990, the cross-reactivity of streptococcal antigen with myocardial antigens on a clonal level was uncovered. Hence, for both historical reasons and mechanistic understanding, it is best to provide evidence for cross-reactivity at the clonal level to prove that molecular mimicry exists.
Molecular Mimicry
and over one million other books are available for Amazon Kindle.
Learn more
FREE Two-Day Shipping for students on millions of items. Learn more |
| |||||||||||||||
Book Description
Editorial Reviews
From the Back Cover
(Text will follow)
Product Details
Would you like to update product info or give feedback on images?
|
Customer Reviews
|
There are no customer reviews yet.
|
|||
|
Video reviews
|
Inside This Book
(learn more)
Key Phrases - Statistically Improbable Phrases (SIPs):
(learn more)
myosin autoimmunity, chlamydial proteins, immunodominant myelin basic protein peptide, molecular mimicry model, chagasic patients, chagas heart disease, chagasic cardiopathy, parasite persistence, inflammatory heart disease, antigen features, cruzi infection, autoimmune demyelinating disease, microbial peptides, encephalitogenic site, mimic epitope, bystander activation, parasite replication, chronic chagas, molecular mimics, epitope spreading, cryptic epitopes, peptide side chains, cell clones, myelin antigens, antigenic mimicry Key Phrases - Capitalized Phrases (CAPs): (learn more)
Exp Med, Clin Invest, Proc Natl Acad Sci, Nat Med, Ann Neurol, Infect Dis, Springer-Verlag Berlin Heidelberg, Higuchi Mde, Infect Immun, Trop Med Hyg, Curr Topics Microbiol Immunol, Mem Inst Oswaldo Cruz, New York, Clin Immunol Immunopathol, Comp Neurol, Faroe Islands, Lopez Bergami, Nat Immunol, Biol Chem, Brain Res, Cardiovasc Pathol, Clin Exp Immunol, Curr Opin Immunol, Dal Canto, High Mild Chlamydia New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
myosin autoimmunity, chlamydial proteins, immunodominant myelin basic protein peptide, molecular mimicry model, chagasic patients, chagas heart disease, chagasic cardiopathy, parasite persistence, inflammatory heart disease, antigen features, cruzi infection, autoimmune demyelinating disease, microbial peptides, encephalitogenic site, mimic epitope, bystander activation, parasite replication, chronic chagas, molecular mimics, epitope spreading, cryptic epitopes, peptide side chains, cell clones, myelin antigens, antigenic mimicry Key Phrases - Capitalized Phrases (CAPs): (learn more)
Exp Med, Clin Invest, Proc Natl Acad Sci, Nat Med, Ann Neurol, Infect Dis, Springer-Verlag Berlin Heidelberg, Higuchi Mde, Infect Immun, Trop Med Hyg, Curr Topics Microbiol Immunol, Mem Inst Oswaldo Cruz, New York, Clin Immunol Immunopathol, Comp Neurol, Faroe Islands, Lopez Bergami, Nat Immunol, Biol Chem, Brain Res, Cardiovasc Pathol, Clin Exp Immunol, Curr Opin Immunol, Dal Canto, High Mild Chlamydia New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Citations (learn more)
This book cites 23
books:
See all 23 books this book cites
- Current Topics in Microbiology and Immunology (Current Topics in Microbiology and Immunology Series) by M. Cooper in Front Matter, page 66, and Back Matter
- Current Topics in Microbiology and Immunology by M. Cooper in Front Matter, and Back Matter
- Antibodies in Viral Infection (Current Topics in Microbiology and Immunology) by Dennis R. Burton in Back Matter
- Cellular Factors Involved in Early Steps of Retroviral Replication. Current Topics in Microbiology and Immunology, No. 281 by John A.T. Young in Back Matter
- Chronic Lymphocytic Leukemia (Current Topics in Microbiology and Immunology, No. 294) by Federico Caligaris-Cappio in Back Matter
See all 23 books this book cites
Books on Related Topics
(learn more)
|
Tag this product(What's this?)Think of a tag as a keyword or label you consider is strongly related to this product.
Tags will help all customers organize and find favorite items. |
Customer Discussions
|
This product's forum
Active discussions in related forums
Search Customer Discussions
|
Related forums
|
Listmania!
So You'd Like to...
Look for Similar Items by Category
- Books > Health, Fitness & Dieting > Disorders & Diseases > Lupus
- Books > Health, Fitness & Dieting > Disorders & Diseases > Multiple Sclerosis
- Books > Medical Books > Basic Sciences > Immunology
- Books > New & Used Textbooks > Medicine & Health Sciences > Medicine > Basic Sciences > Immunology
- Books > Science & Math > Biological Sciences > Biology > Microbiology
