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Moments of Truth in Genetic Medicine [Paperback]

M. Susan Lindee (Author)
5.0 out of 5 stars  See all reviews (2 customer reviews)

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Book Description

0801891019 978-0801891014 October 15, 2008 1

Genetic research increasingly dominates medical thought and practice in the United States and in many other industrialized nations. Susan Lindee's original study explores the institutions, disciplines, and ideas that initiated the reconfiguration of genetic medicine from a marginal field in the mid-1950s to a core research frontier of biomedicine.

Tracing the work of geneticists and other experts in identifying and classifying disease during the explosive period between 1950 and 1980, Lindee identifies the individual "moments of truth" that moved the field away from its eugenic past to the center of a new world view in which nearly all disease is understood to be fundamentally genetic. She suggests that these moments of truth were experienced not only by scientists but also by those who had familial, intimate, emotional knowledge of hereditary disease: patients, family members, and research subjects.

Focusing on benchmarks in the field—such as the rise of neonatal testing in the 1960s, genetic studies of unique human populations such as the Amish, the development of human cytogenetics and human behavioral genetics, and the efforts to find genes for rare diseases such as familial dysautonomia—she tracks the emergence of a biomedical consensus that nearly all disease is genetic disease.

Using the success of this field as a point of entry, Lindee chronicles both the production of knowledge in biomedicine and changes in the cultural meaning of the body in the late twentieth century. She suggests that scientific knowledge is a community project that is shaped directly by people in many different social and professional locations. The power to experience and report scientific truth may be much more dispersed than it sometimes appears, because people know things about their own bodies, and their knowledge has often been incorporated into the technical infrastructure of genomic medicine.

Lindee's pathbreaking study shows the interdependence of technical and social parameters in contemporary biomedicine.


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Editorial Reviews

Review

These fascinating, well-written stories portray what it is like to work in human or medical genetics, both in the clinic and as a researcher.

(Uta Francke Nature 2006)

As difficult as it is to pinpoint the key events in history, Lindee manages this well, singling out and humanising the most important events and players.

(Lindsay Banham Lancet 2006)

This history will reward anyone interested in the paths from gene discoveries to cures or the potential for genomic medicine.

(Science 2006)

Captures the complexities of research on genetic disease while prompting us to reconsider the distribution of scientific authority and the dynamics of knowledge production.

(Michael R. Dietrich New England Journal of Medicine 2006)

An elegant, accessible, even thrilling book that is itself a moment of historical truth and a must-read.

(Alice Wexler Bulletin of the History of Medicine 2006)

An important contribution to our understanding of the making of the future of medicine, not just substantively, but methodologically as well.

(Paolo Palladino Journal of History of Biology 2006)

Provocative and thoughtful... An important and interesting exploration of post–World War II genetics and its impact on the current revolution in genetics and biology.

(Michael Yudell Journal of the History of Medicine and Allied Sciences 2006)

Lindee argues that the production of scientific knowledge is a community project involving not just researchers, but also research subjects, patients and their families... The resulting insight into the structure and organization of contemporary biomedicine is one of the chief contributions of this original and important new book.

(Diane Paul Medical History 2007)

Moments of Truth in Genetic Medicine opens up an important area of contemporary biomedicine, the 'genetization' of disease, to historical scrutiny, looking for decisive turning points far beyond the narrow confines of molecular genetics. Written in a highly accessible style, it will be of interest to anyone concerned with the making of biomedical knowledge, genetic and otherwise.

(Soraya de Chadarevian Isis 2007)

A fascinating and thorough job of summarizing the emergence of human genetics from an almost totally ignored discipline to its current position as one of the most high-profile biomedical and societal endeavors.

(Ronald G. Davidson American Journal of Medical Genetics Part A 2006)

Thoughtful book... Raises novel issues about the rise of genetic knowledge and formulates questions and strategies that are critical to understanding both the past and future of genetic medicine.

(Stephen Pemberton History and Philosophy of the Life Sciences 2006)

A highly readable, fascinating analysis of a trend in medicine whose velocity is dizzyingly rapid. Beautifully written and full of creative insight into the research and discovery process. A great story.

(Rayna Rapp, New York University 2009)

An invaluable history of the late twentieth century's new medical genetics. With a historian's sense of perspective and a sociologist's sense of discipline and structure, Lindee has written what will become an indispensable introduction to an increasingly central aspect of contemporary medicine—and society.

(Charles E. Rosenberg, Harvard University )

A 'must' for any health library concerned with health history, particularly at the college level.

(Midwest Book Review )

From the Back Cover

Susan Lindee's original study explores the institutions, disciplines, and ideas that initiated the reconfiguration of genetic medicine from a marginal field in the mid-1950s to a core research frontier of biomedicine. Tracing the work of geneticists and other experts in identifying and classifying disease during the explosive period between 1950 and 1980, Lindee identifies the individual "moments of truth" that moved the field away from its eugenic past to the center of a new world view in which nearly all disease is understood to be fundamentally genetic.

"These fascinating, well-written stories portray what it is like to work in human or medical genetics, both in the clinic and as a researcher."— Nature

"As difficult as it is to pinpoint the key events in history, Lindee manages this well, singling out and humanising the most important events and players."— Lancet

"This history will reward anyone interested in the paths from gene discoveries to cures or the potential for genomic medicine."— Science

"Captures the complexities of research on genetic disease while prompting us to reconsider the distribution of scientific authority and the dynamics of knowledge production."— New England Journal of Medicine

"An elegant, accessible, even thrilling book that is itself a moment of historical truth and a must-read."— Bulletin of the History of Medicine

" Moments of Truth in Genetic Medicine opens up an important area of contemporary biomedicine, the 'genetization' of disease, to historical scrutiny, looking for decisive turning points far beyond the narrow confines of molecular genetics. Written in a highly accessible style, it will be of interest to anyone concerned with the making of biomedical knowledge, genetic and otherwise."— Isis

Susan Lindee is a professor of history at the University of Pennsylvania.


Product Details

  • Paperback: 288 pages
  • Publisher: The Johns Hopkins University Press; 1 edition (October 15, 2008)
  • Language: English
  • ISBN-10: 0801891019
  • ISBN-13: 978-0801891014
  • Product Dimensions: 9 x 6 x 0.6 inches
  • Shipping Weight: 14.4 ounces (View shipping rates and policies)
  • Average Customer Review: 5.0 out of 5 stars  See all reviews (2 customer reviews)
  • Amazon Best Sellers Rank: #1,577,039 in Books (See Top 100 in Books)

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5.0 out of 5 stars A 'must' for any health library concerned with health history, particularly at the college level, January 12, 2009
This review is from: Moments of Truth in Genetic Medicine (Paperback)
Susan Lindee's original study explores the history of ideas and disciplines that interacted to turn genetic medicine from a marginal field in the mid-1950s to the foundations of biomedicine it is today. Moments of Truth in Genetic Medicine offers a fine survey of the work of geneticists, discussing social issues, public doubts and awareness, historic technological breakthroughs, and more. It's a 'must' for any health library concerned with health history, particularly at the college level.
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1 of 2 people found the following review helpful:
5.0 out of 5 stars Great book on new medical genetics, January 3, 2006
I loved this book. It gave me a new perspective on how genetic medicine is changing our lives and our world. As a friend of someone with a genetic disease, it helped me think about her life in new ways.
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Inside This Book (learn more)
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First Sentence:
Human genetics was transformed from a medical backwater to an appealing medical research frontier between 1955 and 1975. Read the first page
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
postwar human genetics, medical prominence, white male twins, public health genetics, veteran twins, familial dysautonomia, neonatal testing, nonwhite infants, genomic medicine, zygosity diagnosis, chromosomal disease, human cytogenetics, netic disease, familiar seeing, genetic support groups, twin registry, human behavior genetics, twin method, human karyotype, human geneticists, twin research, twin registries, emotional knowledge, genomic science, phenylalanine diet
Key Phrases - Capitalized Phrases (CAPs): (learn more)
United States, New York, Children's Bureau, Johns Hopkins, Lancaster County, Ellis-van Creveld, Ashkenazi Jews, Human Genome Project, Childress Bureau, National Institutes of Health, Old Order Amish, Department of Health, Mendelian Inheritance, American Journal of Human Genetics, Dysautonomia Foundation, Felicia Axelrod, University of Michigan, Veteran Twin Registry, World War, Atomic Energy Commission, Babies Hospital, Dysautonomia Day, Francis Collins, Medical Follow-Up Agency, Ann Arbor
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