Resistance to chemotherapy, and especially multi-drug resistance, represents a significant barrier to the successful treatment of cancer. This multi-author volume brings together a wide range of up-to-date reviews on different aspects of our knowledge of drug-resistance mechanisms, written by experts in the different areas. Particular attention is paid to recently discovered mechanisms relating to oncogene expression and in particular to proteins involved in regulation and execution of apoptosis. Other important topics covered include DNA repair, topoisomerases, cell cycle control, oxygenation and vascularisation of tumours, LRP, intermediate filament proteins and low-level resistance. Recent developments in understanding the role of efflux pumps (P-170, MRP) in multi-drug resistance are also reviewed. This book will be useful to clinicians and scientists working in the areas of chemotherapy, drug resistance, DNA repair and apoptosis research.
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anticancer prostaglandins, drug cross resistance, first intron enhancer, daunomycin accumulation, multidrug resistant cell lines, ntultidrug resistance, leukaemic blast cells, multicellular resistance, drug resistant sublines, mdrl gene expression, gene specific repair, cell sublines, ovarian cancer tissues, major vault protein, pgp expression, cell death machinery, continuous drug exposure, camptothecin resistance, lung resistance protein, human ovarian cancer cells, human ovarian cancer cell lines, daunorubicin resistance, reduced drug accumulation, sense oligo, adduct repair Key Phrases - Capitalized Phrases (CAPs): (learn more)
Cancer Res, Biol Chem, Cancer Inst, Proc Natl Acad Sci, Biochim Biophys Acta, Oncol Res, Nucleic Acids Res, Mol Pharmacol, New York, Biochem Biophys Res Commun, Clin Oncol, Sigma Chemicals, Biol Client, Kluwer Academic Publishers, Nature Med, Biol Cheat, Annu Rev Biochem, Cell Growth Differ, Cell Physiol, Med Chem, Mol Biol, Cancel Res, Cancer Lett, Mutat Res, Oude Elferink New!
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anticancer prostaglandins, drug cross resistance, first intron enhancer, daunomycin accumulation, multidrug resistant cell lines, ntultidrug resistance, leukaemic blast cells, multicellular resistance, drug resistant sublines, mdrl gene expression, gene specific repair, cell sublines, ovarian cancer tissues, major vault protein, pgp expression, cell death machinery, continuous drug exposure, camptothecin resistance, lung resistance protein, human ovarian cancer cells, human ovarian cancer cell lines, daunorubicin resistance, reduced drug accumulation, sense oligo, adduct repair Key Phrases - Capitalized Phrases (CAPs): (learn more)
Cancer Res, Biol Chem, Cancer Inst, Proc Natl Acad Sci, Biochim Biophys Acta, Oncol Res, Nucleic Acids Res, Mol Pharmacol, New York, Biochem Biophys Res Commun, Clin Oncol, Sigma Chemicals, Biol Client, Kluwer Academic Publishers, Nature Med, Biol Cheat, Annu Rev Biochem, Cell Growth Differ, Cell Physiol, Med Chem, Mol Biol, Cancel Res, Cancer Lett, Mutat Res, Oude Elferink New!
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Front Cover | Table of Contents | First Pages | Back Cover | Surprise Me!
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