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The Music of Life: Biology Beyond Genes [Hardcover]

Denis Noble (Author)
4.8 out of 5 stars  See all reviews (6 customer reviews)

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Book Description

July 13, 2006 0199295735 978-0199295739
The gene's eye view of life, proposed in Richard Dawkins acclaimed bestseller The Selfish Gene, sees living bodies as mere vehicles for the replication of genetic codes. But in The Music of Life, world renowned physiologist Denis Noble argues that, to truly understand life, we must look beyond the "selfish gene" to consider life on a much wider variety of levels.
Life, Noble asserts, is a kind of music, a symphonic interplay between genes, cells, organs, body, and environment. He weaves this musical metaphor throughout this personal and deeply lyrical work, illuminating ideas that might otherwise be daunting to non-scientists. In elegant prose, Noble sets out a cutting-edge alternative to the gene's eye view, offering a radical switch of perception in which genes are seen as prisoners and the organism itself is a complex system of many interacting levels. In his more expansive view, life emerges as a process, the ebb and flow of activity in an intricate web of connections. He introduces readers to the realm of systems biology, a field that has been growing in strength in the past decade. Noble, himself one of the founders of this field, argues modern systems biology may be the view we need to adopt to gain a deeper understanding of the nature of life.
Drawing on his experiences in his research on the heartbeat, and on evolutionary biology, development, medicine, philosophy, linguistics, and Chinese culture, Noble presents us with a profound and very modern reflection on the nature of life.

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Editorial Reviews

Review

An excellent informal introduction to the concepts and issues that form the bedrock of systems biology... His conversational style gives readers the feeling they are with him sharing in an active process of discovery. Eric Werner, Science highly evocative essay Steven Poole, Guardian

About the Author


Denis Noble is Emeritus Professor of Cardiovascular Physiology at the University of Oxford. He was Chairman of the International Union of Physiological Sciences World Congress in 1993, and Secretary-General of IUPS from 1993-2001.

Product Details

  • Hardcover: 176 pages
  • Publisher: Oxford University Press, USA (July 13, 2006)
  • Language: English
  • ISBN-10: 0199295735
  • ISBN-13: 978-0199295739
  • Product Dimensions: 7.9 x 5.2 x 0.9 inches
  • Shipping Weight: 10.6 ounces (View shipping rates and policies)
  • Average Customer Review: 4.8 out of 5 stars  See all reviews (6 customer reviews)
  • Amazon Best Sellers Rank: #1,117,010 in Books (See Top 100 in Books)

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10 of 10 people found the following review helpful:
5.0 out of 5 stars Finally someone with knowledge and common (scientific) sense!, August 31, 2006
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This review is from: The Music of Life: Biology Beyond Genes (Hardcover)
Dr. Noble is one of the most creative physiologists of our time, and not surprisingly he decided to put an end to the endless "DNA craze" affecting scientists and media alike. In an era where everything is "genetic", Dr. Noble lucidly unmasks the pitfalls of gene-centrism, to reveal the powerful and obvious societal and organismal influences that govern gene expression. This little book does not deny the work by Dawkins and Gould (frequently and appropriately cited) but rather redefines the modern Darwinism of life in a more holistic, and scientifically acceptable perspective. The devil is in the details, and we have been fooled for too long by those who only see the music notation of life and not the whole symphony!
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7 of 7 people found the following review helpful:
5.0 out of 5 stars One of the most important books I have ever read., August 13, 2006
This review is from: The Music of Life: Biology Beyond Genes (Hardcover)
I honestly really enjoyed reading the book "The Music of Life" - it is one of the most important books I have ever read. Denis Noble's analogy between life and music is an important one. Just as music cannot be understood by investigating single notes at a time, one cannot investigate life by looking at single genes only. The interplay between genes, between genes and proteins, and between proteins is just as important as the genes themselves.

What makes this book particularly interesting is the combination of state of the art knowledge in many totally different fields - it is rare to find a book with so many well founded and important philosophical implications of the scientific discoveries in our time. I had to read this book twice to really appreciate all the beautiful metaphors, and I would recommend this book to everybody that enjoyed Erwin Schrödinger's book "What is Life" - this book is an update.
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5 of 5 people found the following review helpful:
5.0 out of 5 stars Inspiration for a Systems Approach to Biology, September 16, 2007
This review is from: The Music of Life: Biology Beyond Genes (Hardcover)
This little book is a real treat. Among other things, it is a timely rebut of the genome-mania that has dominated biological science and popular attention paid to it over the past decade. This is not to say that Noble's book is an anti-genome book. On the contrary, Noble presents the view of the genome as not more (or less) than another few molecules that make up the complex interacting soup of life.

One of the gems in this book is Noble's description on the combinatorial explosion associated with the seemingly straightforward task of developing gene ontologies--the assignment of biological functions to genes. Noble explains in simple terms why it is practically impossible to enumerate necessarily immense set of high-level functions associated with a specific gene, and why the quest to map functions to genes or genes to functions is a hopeless task unless one adopts a systems view.

While The Music of Life is build around analogy, one of the crucial messages of the book is that there is great danger in mistaking analogy for theory in science. Noble's deconstruction of Dawkins' "selfish gene" analogy is a striking example. Noble's essay reveals that some of the great current debates in biology, such as that of the Dawkins view versus the Gould view of evolution are really scientific debates no more than they are arguments about the aesthetic qualities of competing metaphors. From a perspective that seeks rigorous testable hypotheses, the selfish gene is perhaps no more rigorous an idea than a god delusion.

The only nitpick that I have with this book relates to Noble's demonstration of emergent phenomena, using the rhythmic behavior of a cardiac pacemaker cell membrane potential arising from the integrated behavior of a collection of autonomous channels and pumps. Perhaps exaggerating to make a point, Noble describes the keepers of the Mercury computer of London University as oblivious in 1959 to the possibility that periodic solutions could arise from autonomous equations. Surely such behavior should not have been outside the experience of a mathematician, physicist, or engineer in 1959. In fact, even in biology the famous Hodgkin-Huxley model had for years been known to show emergent oscillatory behavior. Noble's professed amazement at the emergence of periodic behavior from his model equations may be an autobiographical fact. But I suspect that the real amazement was in the ability of the model equations to simulate observed behavior quantitatively in terms of not just the phenomenon of oscillations, but the size and shape of the period waveforms. In 1959 Noble was working before the age of instant compiling, online debugging, and rapid nonlinear parameter estimation. To effectively model cardiac pacemaker electrophysiology from the channels up in 1959 was indeed an amazing demonstration of emergent behavior in biology.
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Inside This Book (learn more)
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
virtual heart, pacemaker rhythm, period gene, protein channels, downward causation, rhythm generator, black font, space travellers, ultimate rationale
Key Phrases - Capitalized Phrases (CAPs): (learn more)
Maynard Smith, Sydney Brenner, Francis Crick, Andrew Huxley, East Asian
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