Myelodysplastic syndrome (MDS) is thought to be an incurable disease typified by a clonal disorder in the maturation and proliferation stage of multipotential hematopoietic stem cells. The three main themes in this book are: Influence of cytokines on the maturation and proliferation of normal hematopoietic progenitor cells as well as leukemic cells including those from patients with MDS. Synergisms of cytokines in vitro and in vivo. Clinical features of MDS including BMT. The book provides useful information regarding effective treatments of MDS based on a better understanding of the cytokine actions as well as the association with the hematopoiesis including the network system.
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