This volume constitutes the proceedings of The International Symposium on Nicotinic Receptors in the CNS - Their Role in Synaptic Tranmission held in Uppsala, Sweden from 19-21 June 1988. Ligand binding studies with different nicotinic agonists and antagonists have shown the presence of several different subtypes of nicotonic receptors in the CNS. Studies on molecular biology using expression in the oocyte model indicate that the addition of a beta-2 subunit to either an alpha-2, alpha-3 or alpha-4 subunit produces a receptor that initiates a strong response to either acetylcholine or nicotine. Human studies also indicate the development of adaptive changes in the central nicotinic receptors upon chronic nicotine exposure. These subjects are among those covered in Nicotinic Receptors in the CNS - Their Role in Synaptic Transmission .
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